CareDx, Inc.

CDNA
About the company

CareDx, Inc. provides solutions for improving outcomes for transplant patients and advancing organ health in the United States and internationally. The company provides AlloSure Kidney, a donor-derived cell-free DNA (dd-cfDNA) solution for kidney transplant patients; AlloMap Heart, a gene expression profiling solution for heart transplant patients; AlloSure Heart, a dd-cfDNA solution for heart transplant patients; and AlloSure Lung, a dd-cfDNA solution for lung transplant patients.

Country: United StatesPrice: $77.88Market Cap: $4.1B

Investment snapshot

12%positive consensus
Scored 1d ago

Positive

2

BUY / PASS

Neutral / negative

3 / 11

NEUTRAL / FAIL

Median fair value

—

No comparable estimates

Models with upside

0 / 17

Positive margin of safety

Key risk

No clean pass — all 13 investors flag at least one valuation criterion

Framework analysis

VerdictMeaning
BUYPositive purchase signal: the framework's buy requirements are met.
PASSThe company clears the framework's checklist or screen, but the framework does not produce a buy signal. For valuation frameworks this often means margin of safety is missing, insufficient, or unavailable; some screen-only frameworks have no intrinsic-value BUY state.
NEUTRALNeither a positive nor negative conclusion. It does not mean to hold an existing position.
FAILThe company does not clear the framework's requirements.
RankedRanked strategies do not use PASS: selected cohort is BUY, outside the cohort is FAIL, and unranked is NEUTRAL.

Current investor scores use trailing 12-month flows and the latest balance sheet where supported. Multi-year and EPS tests retain annual history; each framework shows its financial basis below. Intrinsic values use annual financials.

MetricGraham

Defensive Value

Buffett

Quality Compounder

Lynch

GARP

Greenblatt

Magic Formula

Piotroski

F-Score

Dreman

Contrarian Value

Munger

Quality Focus

Pabrai

Dhandho Framework

Akre

Three-Legged Stool

Marks

Risk-Aware Value

Ackman

Activist Value

Templeton

Global Bargain Hunter

Sleep

Scale Economies Shared

Asness

Systematic Factors

Neff

Low-P/E Total Return

Schloss

Asset-Value Discipline

O'Shaughnessy

Systematic Factor Composite

VerdictFAILFAILFAILFAIL · Rank #1999 (Top 64.5%)PASSFAILFAILFAILFAILFAILPASSFAILNEUTRALNEUTRALFAILFAILNEUTRAL
Score
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Intrinsic Value (annual)N/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/A
Margin of SafetyN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/A
Financial Basis

TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Annual history · FY 2025

Latest source filing: 2026-10-29

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-02-25

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-09-30 vs 2025-09-30 · TTM ended 2026-09-30

Latest source filing: 2026-10-29

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-02-25

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-02-25

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Market data at 2026-11-01

Latest source filing: 2026-10-29

Score computed: 2026-11-14

Qualitative assessment · Annual history · FY 2025

Latest source filing: 2026-02-25

Score computed: 2026-11-14

Qualitative assessment · Annual history · FY 2025

Latest source filing: 2026-02-25

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment

Latest source filing: 2026-02-25

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment

Latest source filing: 2026-02-25

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-09-30 · Market data at 2026-11-01

Latest source filing: 2026-10-29

Score computed: 2026-11-14

Annual history · FY 2025 · Price history 2025-01-01–2026-11-01

Latest source filing: 2026-02-25

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment

Latest source filing: 2026-02-25

Score computed: 2026-11-14

TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Price history 2025-01-01–2026-11-01 · Annual history · FY 2025

Latest source filing: 2026-10-29

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-02-25

Score computed: 2026-11-14

Annual history · FY 2025 · Balance sheet at 2026-09-30

Latest source filing: 2026-10-29

Score computed: 2026-11-14

TTM ended 2026-09-30 · Annual history · FY 2025 · Price history 2025-01-01–2026-11-01

Latest source filing: 2026-10-29

Score computed: 2026-11-14

Where It Passes

    Where It Falls Short

    • Valuation0% pass✓ 2✗ 26▾

      No clean pass — all 13 investors flag at least one valuation criterion

      Price / 3-yr avg EPS
      ✗Graham<= 15x
      Price-to-Book Ratio13.2x
      ✗Graham<= 1.5x
      P/E x P/B
      ✗Graham<= 22.5
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      EBIT / Enterprise Value-0.8%
      ✗Greenblatt> 10%
      Earnings Yield + ROC AssessmentEY=-0.8%, ROC=-22.8%
      ✗GreenblattBoth EY > 10% and ROC > 25%
      Price / EPS
      ✗Dreman< 12x✗Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)
      Price / (CFO / Shares)94.9x
      ✗Dreman< 8x
      Price / Book Value per Share13.2x
      ✗Dreman< 1.2x✗Templeton< 1.5x✗SchlossP/B <= 0.80x (app cutoff)
      Valuation ReasonablenessOE Yield=-0.2%
      ✗MungerP/E < 25 or Owner Earnings Yield > 5%
      P/E or FCF Yield
      ✗PabraiP/E < 15 or FCF Yield > 10%
      P/B or P/E vs. Historical AverageP/B=13.2x
      ✗MarksP/E < 15 or P/B < 2.0
      Discount to Intrinsic ValueN/A (negative normalized EPS)
      ✗Marks>= 20% below intrinsic value
      Price / FCF per Share
      ✗Ackman<= 25
      Price vs. Trailing Low634% of trailing low ($12.28)
      ✗Templeton<= 120% of trailing low (certified split-adjusted live window)
      Net income / market capitalization+3.14%; #2324/6340 (top 36.7%)
      ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
      Positive book equity / market capitalization+0.1142; #4667/6449 (top 72.4%)
      ✗AsnessTop 30% of eligible cross-section
      Price / Diluted EPS
      ✗NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)
      (EPS CAGR % + Dividend Yield %) / P/E
      ✗Neff> 0.7 (Neff's published traditional edge)
      Price / Tangible Book Value per Share17.28x
      ✗SchlossP/TBV <= 1.00x (app cutoff)
      Book Value per Share Change+5.4%
      ✓SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)
      Revenue / market capitalization+0.1216; #4220/5247 (top 80.4%)
      ✗OshaughnessyTop 10% of eligible cross-section
      (Operating cash flow - capex) / market capitalization
      ✗OshaughnessyTop 10% of eligible cross-section
      Trailing six-month price return through the evaluation date+385.23%; #94/6202 (top 1.5%)
      ✓OshaughnessyTop 10% of eligible cross-section
    • Debt & Leverage8% pass✓ 3✗ 12▾

      11 of 12 flag CDNA's debt & leverage — Graham, Buffett, Lynch +8 more

      LT Debt vs Net Current Assets
      ✗GrahamLT Debt <= Net Current Assets
      Debt/Equity & Interest Coverage
      ✗BuffettD/E < 0.5 AND Interest Coverage > 5x
      Total Debt / Equity
      ✗Lynch< 0.33
      Cash - Long-term Debt
      ✗LynchPositive preferred
      LT Debt / Total Assets Change0.00% -> 0.00%
      ✓PiotroskiDecreased YoY
      Current Assets / Current Liabilities2.31
      ✓Dreman> 1.5✓SchlossCurrent ratio >= 1.50x (app cutoff)
      Total Debt / Shareholders' Equity
      ✗Dreman< 0.8✗Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✗SchlossD/E < 1.00x
      Debt Levels
      ✗MungerDebt/Equity < 0.5✗AkreDebt/Equity < 0.3
      Interest Coverage & Debt/EBITDA
      ✗MarksInterest Coverage > 3x; Debt/EBITDA < 4x
      Total Debt / Shareholders Equity
      ✗Ackman<= 1.0
      Negative debt-to-equity (higher means less debt)
      ✗AsnessTop 30% of eligible cross-section
    • Cash Flow10% pass✓ 2✗ 10▾

      9 of 10 flag CDNA's cash flow — Buffett, Lynch, Dreman +6 more

      Free Cash Flow Proxy$-177.7M
      ✗BuffettPositive and growing
      FCF Positive and Growing$-20.2M
      ✗LynchPositive and growing
      Operating Cash Flow$42.0M
      ✓PiotroskiCFO > 0
      (CFO / Total Assets) vs ROACFO/Assets=10.17%, ROA=-5.17%
      ✓PiotroskiCFO/Assets > ROA
      Price / (CFO / Shares)94.9x
      ✗Dreman< 8x
      P/E or FCF Yield
      ✗PabraiP/E < 15 or FCF Yield > 10%
      FCF Positive0/8 years FCF positive
      ✗MarksPositive FCF in majority of recent years
      (OCF - CapEx) / Market Cap
      ✗Ackman>= 4%
      Price / FCF per Share
      ✗Ackman<= 25
      Positive Operating Cash Flow frequency3/14 years positive
      ✗SleepPositive OCF in >= 70% of available years
      Operating Cash Flow - Capital Expenditures
      ✗Neff> $0 (app proxy for a strong fundamental case)
      (Operating cash flow - capex) / market capitalization
      ✗OshaughnessyTop 10% of eligible cross-section
    • Growth13% pass✓ 4✗ 9▾

      7 of 8 flag CDNA's growth — Graham, Lynch, Dreman +4 more

      EPS Growth (3-yr avg, 10-yr window)
      ✗Graham>= 33% growth
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      3-5 Year EPS CAGR
      ✗Lynch15-30% (Fast Grower); > 0% to pass
      Inventory Growth vs Revenue GrowthInv: -67.7% vs Rev: 38.9%
      ✓LynchInventory growth < Revenue growth
      EPS Growth Direction
      ✗DremanPositive over recent years
      EPS CAGR
      ✗Dreman> 5% annualized
      Positive Net Income Frequency2/14 years positive
      ✗MarksPositive net income in >= 7 of last 10 years
      3yr Median Revenue Growth13.8%
      ✓Ackman>= 5%
      Positive EPS Growth Frequency1/5 years with positive EPS growth
      ✗AckmanPositive EPS growth in >= 3 of last 5 years
      5-Year EPS CAGR
      ✗Templeton> 0% (5-year EPS CAGR)
      Revenue growth vs. gross and operating margin trendrevenue up, operating margin -72.5% -> -8.1%
      ✓SleepRevenue rising; gross margin flat or falling; operating margin holding
      5-year Revenue CAGR14.6%
      ✓SleepCAGR > 7%
      3-5 Year Diluted EPS CAGR
      ✗Neff7%-20% annualized
    • Verdicts14% pass✓ 2✗ 12▾

      Split decision: 11 FAIL · 3 NEUTRAL · 2 PASS

      Overall verdict
      ✗GrahamFAIL (2/9)✗BuffettFAIL (1/9)✗LynchFAIL (2/7)✗GreenblattRank #1999✓PiotroskiPASS (F-Score 5)✗DremanFAIL (4/11)✗MungerFAIL (1/4)✗PabraiFAIL (0/3)✗AkreFAIL (0/6)✗MarksFAIL (0/5)✓AckmanPASS (5/9)✗TempletonFAIL (2/8)•SleepNEUTRAL (4/6)•AsnessNEUTRAL (Not ranked)✗NeffFAIL (1/6)✗SchlossFAIL (2/7)•OshaughnessyNEUTRAL (Not ranked)
    • Profitability19% pass✓ 10✗ 25▾

      13 of 16 flag CDNA's profitability — Graham, Buffett, Lynch +10 more

      Positive EPS (10 years)2/15 years positive
      ✗GrahamPositive EPS every year for 10 years
      EPS Growth (3-yr avg, 10-yr window)
      ✗Graham>= 33% growth
      Net Income Positive (10+ years)2/15 years positive
      ✗BuffettPositive every year for 10+ years
      ROE (up to 5-year arithmetic mean)-18.1%
      ✗Buffett> 15% arithmetic mean (app rule)
      Operating Margin (10-yr trend)-8.1% (latest)
      ✓BuffettStable or rising over 10 years
      Free Cash Flow Proxy$-177.7M
      ✗BuffettPositive and growing
      Earnings Variance (10-yr CoV)
      ✗BuffettCoV < 0.3
      Retained Earnings Effectiveness
      ✗Buffett$1 retained -> > $1 market value created
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      3-5 Year EPS CAGR
      ✗Lynch15-30% (Fast Grower); > 0% to pass
      ROE27.5%
      ✓Lynch> 15%
      EBIT / Enterprise Value-0.8%
      ✗Greenblatt> 10%
      Earnings Yield + ROC AssessmentEY=-0.8%, ROC=-22.8%
      ✗GreenblattBoth EY > 10% and ROC > 25%
      Net Income / Total Assets-5.17%
      ✗PiotroskiROA > 0
      ROA Change YoY10.70% -> -5.17% (delta: -15.87%)
      ✗PiotroskiCurrent ROA > Prior ROA
      (CFO / Total Assets) vs ROACFO/Assets=10.17%, ROA=-5.17%
      ✓PiotroskiCFO/Assets > ROA
      Gross Margin Change YoY
      ✗PiotroskiImproved YoY
      Pre-Tax Income / Revenue25.0%
      ✓Dreman>= 8%
      Net Income / Shareholders' Equity27.5%
      ✓Dreman> 12%
      Margin of SafetyP/B=13.2x
      ✗PabraiP/B < 1.5 or P/E < 15
      Return on Equity-22.0% (3-yr avg)
      ✗AkreROE > 20% (3-year avg)
      Discount to Intrinsic ValueN/A (negative normalized EPS)
      ✗Marks>= 20% below intrinsic value
      Positive Net Income Frequency2/14 years positive
      ✗MarksPositive net income in >= 7 of last 10 years
      Operating Income / Revenue23.4%
      ✓Ackman>= 15%
      Net Income / Shareholders Equity27.5%
      ✓Ackman>= 15%
      5-Year EPS CAGR
      ✗Templeton> 0% (5-year EPS CAGR)
      Operating Margin Trend-72.5% (2023) -> -8.1% (2025)
      ✓TempletonNon-negative operating-margin trend over 3 years
      Revenue growth vs. gross and operating margin trendrevenue up, operating margin -72.5% -> -8.1%
      ✓SleepRevenue rising; gross margin flat or falling; operating margin holding
      Net income / market capitalization+3.14%; #2324/6340 (top 36.7%)
      ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
      Gross profit / total assets
      ✗AsnessTop 30% of eligible cross-section
      Net income / positive book equity+27.52%; #516/5226 (top 9.9%)
      ✓AsnessTop 30% of eligible cross-section
      Negative 5-year standard deviation of ROA-0.1692; #4049/5884 (top 68.8%)
      ✗AsnessTop 30% of eligible cross-section
      3-5 Year Diluted EPS CAGR
      ✗Neff7%-20% annualized
      Positive Diluted-EPS Years1/10 years positive
      ✗Schloss>= 70% positive over 5-10 observed years (app rule)
    • Efficiency25% pass✓ 3✗ 8▾

      6 of 8 flag CDNA's efficiency — Buffett, Greenblatt, Piotroski +3 more

      Current Ratio2.31
      ✓Graham>= 2.0
      ROIC (3-5 yr avg)-69.3%
      ✗Buffett> 10%
      ROIC - WACC-79.3%
      ✗BuffettPositive (WACC = 10%)
      EBIT / (NWC + Net Fixed Assets)-22.8%
      ✗Greenblatt> 25%
      Current Ratio Change YoY3.94 -> 2.86
      ✗PiotroskiIncreased YoY
      Revenue / Total Assets Change YoY0.68x -> 0.92x
      ✓PiotroskiImproved YoY
      Current Assets / Current Liabilities2.31
      ✓Dreman> 1.5
      Return on Invested Capital
      ✗Munger> 15%
      ROIC (high and growing)FY2023: ROIC=unavailable; FY2024: ROIC=unavailable; FY2025: ROIC=unavailable
      ✗AkreLatest 3 consecutive FYs: ROIC > 15% in each
      Reinvestment Rate x ROIC
      ✗AkreReinvestment Rate * ROIC > 10%
      ROIC (5-year)
      ✗SleepROIC > 12% in a majority of years

    Business & financials

    Financial snapshot: annual FY 2025. Current investor scores may use newer quarterly data.

    Company Profile

    Industry: Healthcare
    SIC Sector: Health Services
    Size: Mid Cap($4.1B)
    Revenue: $379.8M+13.8% YoY
    Net Income: $21.4M-140.6% YoY

    Financial Snapshot

    Operating Margin-8.1%
    Return on Equity-7.0%
    Debt / Equity--
    Current Ratio2.86
    EPS (Diluted)$-0.40
    Buybacks (1y)$87.8M
    Buybacks (2y)$88.3M
    Shares Retired7.6% / 1.1% 2y

    Shareholder Return

    Fiscal 2025

    Retired 7.6% of shares last year, 1.1% over two.

    Buybacks
    $87.8M
    Dividends
    —

    Company Financials

    Latest TTM and quarters alongside annual years

    TTM sums four consecutive quarters and uses the latest quarter-end balances. Quarter columns show three-month results; annual columns show full-year totals. Growth compares the same period a year earlier. EPS is not added for TTM; full-year ratios are blank for quarters.

    The latest annual period end is unavailable. Showing the latest fiscal cycle’s quarters; quarter and annual columns may overlap. Quarterly shows the full quarter history.

    MetricTTM · 2026-09-30

    2025-10-01 – 2026-09-30

    Sources · derived quarter values

    Derived from cumulative filings: revenue, net income, operating income, ebit, pre tax income, operating cash flow, depreciation amortization, buybacks, capex.

    Q3 FY 2026

    2026-07-01 – 2026-09-30

    Sources · derived quarter values

    Derived from cumulative filings: operating cash flow, depreciation amortization, capex, buybacks.

    Q2 FY 2026

    2026-04-01 – 2026-06-30

    Sources · derived quarter values

    Derived from cumulative filings: operating cash flow, depreciation amortization, capex.

    Q1 FY 2026

    2026-01-01 – 2026-03-31

    Sources
    FY 2025
    Sources
    • 10-K · 2026-02-25
    FY 2024
    Sources
    • 10-K · 2025-02-28
    FY 2023
    Sources
    • 10-K · 2024-02-28
    FY 2022
    Sources
    • 10-K · 2023-02-27
    FY 2021
    Sources
    • 10-K · 2022-02-24
    Market Cap$4.1Bcurrent------$1.1Best.$1.3Best.$443.2Mest.$801.9Mest.$2.2Best.
    Revenue$497.4M↑39%$139.4M↑39%$131.9M↑52%$117.7M↑39%$379.8M↑14%$333.8M↑19%$280.3M↓13%$321.8M↑9%$296.4M
    Operating Income$116.5M↑133%$8.1M↑3398%$113.2M↑1118%$1.2M↑109%-$30.8M↓176%$40.8M↑120%-$203.4M↓163%-$77.2M↓160%-$29.7M
    Net Income$128.6M↑112%$19.3M↑1052%$110.6M↑1391%$2.8M↑127%-$21.4M↓141%$52.5M↑128%-$190.3M↓148%-$76.6M↓150%-$30.7M
    EPS (Diluted)--$0.35↑1067%$2.07↑1394%$0.05↑126%$-0.40↓143%$0.93↑126%$-3.54↓146%$-1.44↓144%$-0.59
    Gross Margin—————————
    Operating Margin23.4%↑68%5.8%↑2467%85.8%↑769%1.0%↑106%-8.1%↓166%12.2%↑117%-72.5%↓202%-24.0%↓139%-10.0%
    ROE27.5%↑41%———-7.0%↓151%13.9%↑119%-72.8%↓310%-17.8%↓170%-6.6%
    Total Debt------------------
    Shareholders' Equity$467.5M↑50%$467.5M↑50%$425.6M↑30%$313.5M↓17%$303.1M↓20%$378.4M↑45%$261.3M↓39%$430.9M↓8%$465.9M
    Current Ratio2.31↓24%2.31↓24%4.58↑39%3.40↓17%2.86↓27%3.94↓2%4.02↓21%5.10↓9%5.61
    Debt / Equity—————————
    Operating Cash Flow$69.0M↑62%$12.7M↓66%$30.6M↑209%$4.3M↑116%$42.0M↑10%$38.0M↑307%-$18.4M↑27%-$25.2M↓31%-$19.3M
    Free Cash Flow--$11.1M$28.7M$514.0K-----$20.2M----

    Score history

    Historical Score Timeline

    Industry peers

    Industry Peers

    Similar companies in Healthcare

    CDNA vs Peers — Financial Grading

    Revenue$379.8MBottom 25%
    Net Income$21.4MBottom 25%
    ROE-7.0%Median
    D/E—
    Op. Margin-8.1%Bottom 25%
    Curr. Ratio2.86Top 25%
    CompanyMarket CapPriceRevenueNet IncomeROED/EOp. MarginCurr. RatioGrahamBuffettLynchGreenblattPiotroskiDreman
    HCA Healthcare, Inc.HCA$104.2B$499.05$75.6B$6.8B-112.6%-7.7113.0%0.971/95/93/71/3F-Score 64/11
    TENET HEALTHCARE CORPTHC$22.8B$286.03$21.3B$2.4B56.1%3.1216.5%1.761/94/93/73/3F-Score 65/11
    Guardant Health, Inc.GH$20.5B$151.70$982.0M$416.3M419.2%-15.14-44.5%4.842/91/91/70/3F-Score 52/11
    EXACT SCIENCES CORPEXAS$20.0B$104.91$3.2B$207.9M-8.7%0.00-6.4%2.432/91/93/70/3F-Score 73/11
    Fresenius Medical Care AGFMS$11.4B$22.03$23.1B$1.1B7.4%0.819.3%1.265/92/91/70/3F-Score 85/11
    UNIVERSAL HEALTH SERVICES INCUHS$11.2B$194.07$17.4B$1.5B20.5%0.6511.5%1.054/96/95/71/3F-Score 76/11
    DAVITA INC.DVA$11.0B$174.56$13.6B$746.8M-114.7%-15.7815.0%1.291/94/92/71/3F-Score 73/11
    CHEMED CORPCHE$7.1B$548.20$2.5B$265.2M27.1%—13.4%1.054/97/93/71/3F-Score 66/11