Niki BioSolutions, Inc.
NIKIAbout the company
Aptorum Group Limited, through its subsidiaries, a clinical stage biopharmaceutical company, engages in the discovery, development, and commercialization of therapeutic products to treat oncology and infectious diseases. Its pipeline products include SACT-1, a repurposed drug candidate, which is in phase 1 clinical trial to treat neuroblastoma and other cancer types; ALS-4, a repurposed small molecule, which is in phase 1 clinical trial for the treatment of bacterial infections, such as staphylococcus aureus, mycobacterium tuberculosis, and pseudomonas aeruginosa.
Investment snapshot
Positive
1
BUY / PASS
Neutral / negative
3 / 12
NEUTRAL / FAIL
Median fair value
—
No comparable estimates
Models with upside
0 / 17
Positive margin of safety
Key risk
All 10 investors flag NIKI's cash flow
Framework analysis
| Verdict | Meaning |
|---|---|
| BUY | Positive purchase signal: the framework's buy requirements are met. |
| PASS | The company clears the framework's checklist or screen, but the framework does not produce a buy signal. For valuation frameworks this often means margin of safety is missing, insufficient, or unavailable; some screen-only frameworks have no intrinsic-value BUY state. |
| NEUTRAL | Neither a positive nor negative conclusion. It does not mean to hold an existing position. |
| FAIL | The company does not clear the framework's requirements. |
| Ranked | Ranked strategies do not use PASS: selected cohort is BUY, outside the cohort is FAIL, and unranked is NEUTRAL. |
Current investor scores use trailing 12-month flows and the latest balance sheet where supported. Multi-year and EPS tests retain annual history; each framework shows its financial basis below. Intrinsic values use annual financials.
| Metric | Graham Defensive Value | Buffett Quality Compounder | Lynch GARP | Greenblatt Magic Formula | Piotroski F-Score | Dreman Contrarian Value | Munger Quality Focus | Pabrai Dhandho Framework | Akre Three-Legged Stool | Marks Risk-Aware Value | Ackman Activist Value | Templeton Global Bargain Hunter | Sleep Scale Economies Shared | Asness Systematic Factors | Neff Low-P/E Total Return | Schloss Asset-Value Discipline | O'Shaughnessy Systematic Factor Composite |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Verdict | FAIL | FAIL | FAIL | Not ranked | FAIL | FAIL | FAIL | FAIL | FAIL | FAIL | FAIL | PASS | FAIL | NEUTRAL | FAIL | NEUTRAL | NEUTRAL |
| Score | |||||||||||||||||
| Analysis | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… |
| Intrinsic Value (annual) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Margin of Safety | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Financial Basis | Annual history · FY 2025 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 · Market data at 2026-11-01 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Qualitative assessment · Annual history · FY 2025 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Qualitative assessment · Annual history · FY 2025 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 · Market data at 2026-11-01 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-27 Score computed: 2026-11-14 | Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 Latest source filing: 2026-03-27 Score computed: 2026-11-14 |
Where It Passes
Where It Falls Short
- Cash Flow0% pass✗ 12▾
All 10 investors flag NIKI's cash flow
Free Cash Flow Proxy$-1.7M✗BuffettPositive and growingFCF Positive and Growing$-7.7M✗LynchPositive and growingOperating Cash Flow$-1.8M✗PiotroskiCFO > 0(CFO / Total Assets) vs ROACFO/Assets=-9.83%, ROA=-7.29%✗PiotroskiCFO/Assets > ROAPrice / (CFO / Shares)N/A (negative CFPS)✗Dreman< 8xP/E or FCF Yield✗PabraiP/E < 15 or FCF Yield > 10%FCF Positive0/6 years FCF positive✗MarksPositive FCF in majority of recent years(OCF - CapEx) / Market Cap✗Ackman>= 4%Price / FCF per Share✗Ackman<= 25Positive Operating Cash Flow frequency0/8 years positive✗SleepPositive OCF in >= 70% of available yearsOperating Cash Flow - Capital Expenditures✗Neff> $0 (app proxy for a strong fundamental case)(Operating cash flow - capex) / market capitalization✗OshaughnessyTop 10% of eligible cross-section - Growth0% pass✓ 1✗ 12▾
No clean pass — all 8 investors flag at least one growth criterion
EPS Growth (3-yr avg, 10-yr window)N/A (negative base EPS)✗Graham>= 33% growthBasic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)3-5 Year EPS CAGR✗Lynch15-30% (Fast Grower); > 0% to passInventory Growth vs Revenue GrowthN/A (no inventory)✓LynchInventory growth < Revenue growthEPS Growth Direction$-0.53 (2018) -> $-0.19 (2025)✗DremanPositive over recent yearsEPS CAGR✗Dreman> 5% annualizedPositive Net Income Frequency1/8 years positive✗MarksPositive net income in >= 7 of last 10 years3yr Median Revenue Growth-66.7%✗Ackman>= 5%Positive EPS Growth Frequency2/5 years with positive EPS growth✗AckmanPositive EPS growth in >= 3 of last 5 years5-Year EPS CAGR✗Templeton> 0% (5-year EPS CAGR)Revenue growth vs. gross and operating margin trend✗SleepRevenue rising; gross margin flat or falling; operating margin holding5-year Revenue CAGR✗SleepCAGR > 7%3-5 Year Diluted EPS CAGR✗Neff7%-20% annualized - Efficiency0% pass✓ 1✗ 10▾
No clean pass — all 8 investors flag at least one efficiency criterion
Current Ratio0.78✗Graham>= 2.0ROIC (3-5 yr avg)-70.1%✗Buffett> 10%ROIC - WACC-80.1%✗BuffettPositive (WACC = 10%)EBIT / (NWC + Net Fixed Assets)✗Greenblatt> 25%Current Ratio Change YoY0.22 -> 0.78✓PiotroskiIncreased YoYRevenue / Total Assets Change YoY✗PiotroskiImproved YoYCurrent Assets / Current Liabilities0.78✗Dreman> 1.5Return on Invested Capital✗Munger> 15%ROIC (high and growing)FY2023: ROIC=-30.4%; FY2024: ROIC=unavailable; FY2025: ROIC=unavailable✗AkreLatest 3 consecutive FYs: ROIC > 15% in eachReinvestment Rate x ROIC✗AkreReinvestment Rate * ROIC > 10%ROIC (5-year)0/3 years above 12% (latest -30.4%)✗SleepROIC > 12% in a majority of years - Profitability6% pass✓ 2✗ 33▾
15 of 16 flag NIKI's profitability — Graham, Buffett, Lynch +12 more
Positive EPS (10 years)1/10 years positive✗GrahamPositive EPS every year for 10 yearsEPS Growth (3-yr avg, 10-yr window)N/A (negative base EPS)✗Graham>= 33% growthNet Income Positive (10+ years)1/10 years positive✗BuffettPositive every year for 10+ yearsROE (up to 5-year arithmetic mean)-41.2%✗Buffett> 15% arithmetic mean (app rule)Operating Margin (10-yr trend)✗BuffettStable or rising over 10 yearsFree Cash Flow Proxy$-1.7M✗BuffettPositive and growingEarnings Variance (10-yr CoV)N/A (negative mean EPS)✗BuffettCoV < 0.3Retained Earnings Effectiveness✗Buffett$1 retained -> > $1 market value createdBasic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)3-5 Year EPS CAGR✗Lynch15-30% (Fast Grower); > 0% to passROE-5.9%✗Lynch> 15%EBIT / Enterprise Value✗Greenblatt> 10%Earnings Yield + ROC AssessmentEY=None, ROC=None✗GreenblattBoth EY > 10% and ROC > 25%Net Income / Total Assets-7.29%✗PiotroskiROA > 0ROA Change YoY-26.46% -> -7.29% (delta: +19.16%)✓PiotroskiCurrent ROA > Prior ROA(CFO / Total Assets) vs ROACFO/Assets=-9.83%, ROA=-7.29%✗PiotroskiCFO/Assets > ROAGross Margin Change YoY✗PiotroskiImproved YoYPre-Tax Income / Revenue✗Dreman>= 8%Net Income / Shareholders' Equity-5.9%✗Dreman> 12%Margin of SafetyP/B=0.5x✓PabraiP/B < 1.5 or P/E < 15Return on Equity-12.5% (3-yr avg)✗AkreROE > 20% (3-year avg)Discount to Intrinsic ValueN/A (negative normalized EPS)✗Marks>= 20% below intrinsic valuePositive Net Income Frequency1/8 years positive✗MarksPositive net income in >= 7 of last 10 yearsOperating Income / Revenue✗Ackman>= 15%Net Income / Shareholders Equity-5.9%✗Ackman>= 15%5-Year EPS CAGR✗Templeton> 0% (5-year EPS CAGR)Operating Margin Trend✗TempletonNon-negative operating-margin trend over 3 yearsRevenue growth vs. gross and operating margin trend✗SleepRevenue rising; gross margin flat or falling; operating margin holdingNet income / market capitalization-26.50%; #4729/6340 (top 74.6%)✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-sectionGross profit / total assets✗AsnessTop 30% of eligible cross-sectionNet income / positive book equity-5.90%; #3249/5226 (top 62.2%)✗AsnessTop 30% of eligible cross-sectionNegative 5-year standard deviation of ROA-0.3874; #4779/5884 (top 81.2%)✗AsnessTop 30% of eligible cross-section3-5 Year Diluted EPS CAGR✗Neff7%-20% annualizedPositive Diluted-EPS Years1/8 years positive✗Schloss>= 70% positive over 5-10 observed years (app rule) - Valuation8% pass✓ 9✗ 19▾
12 of 13 flag NIKI's valuation — Graham, Lynch, Greenblatt +9 more
Price / 3-yr avg EPS✗Graham<= 15xPrice-to-Book Ratio0.5x✓Graham<= 1.5xP/E x P/B✗Graham<= 22.5Basic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)EBIT / Enterprise Value✗Greenblatt> 10%Earnings Yield + ROC AssessmentEY=None, ROC=None✗GreenblattBoth EY > 10% and ROC > 25%Price / EPS✗Dreman< 12x✗Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)Price / (CFO / Shares)N/A (negative CFPS)✗Dreman< 8xPrice / Book Value per Share0.5x✓Dreman< 1.2x✓Templeton< 1.5x✓SchlossP/B <= 0.80x (app cutoff)Valuation Reasonableness✗MungerP/E < 25 or Owner Earnings Yield > 5%P/E or FCF Yield✗PabraiP/E < 15 or FCF Yield > 10%P/B or P/E vs. Historical AverageP/B=0.5x✓MarksP/E < 15 or P/B < 2.0Discount to Intrinsic ValueN/A (negative normalized EPS)✗Marks>= 20% below intrinsic valuePrice / FCF per Share✗Ackman<= 25Price vs. Trailing Low100% of trailing low ($1.65)✓Templeton<= 120% of trailing low (certified split-adjusted live window)Net income / market capitalization-26.50%; #4729/6340 (top 74.6%)✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-sectionPositive book equity / market capitalization+4.4925; #317/6449 (top 4.9%)✓AsnessTop 30% of eligible cross-sectionPrice / Diluted EPS✗NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)(EPS CAGR % + Dividend Yield %) / P/E✗Neff> 0.7 (Neff's published traditional edge)Price / Tangible Book Value per Share0.52x✓SchlossP/TBV <= 1.00x (app cutoff)Book Value per Share Change+137.0%✓SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)Revenue / market capitalization✗OshaughnessyTop 10% of eligible cross-section(Operating cash flow - capex) / market capitalization✗OshaughnessyTop 10% of eligible cross-sectionTrailing six-month price return through the evaluation date-83.98%; #5899/6202 (top 95.1%)✗OshaughnessyTop 10% of eligible cross-section - Verdicts8% pass✓ 1✗ 12▾
Split decision: 12 FAIL · 3 NEUTRAL · 1 PASS
Overall verdict✗GrahamFAIL (1/9)✗BuffettFAIL (0/9)✗LynchFAIL (2/7)•GreenblattNot ranked✗PiotroskiFAIL (F-Score 3)✗DremanFAIL (2/11)✗MungerFAIL (1/4)✗PabraiFAIL (1/3)✗AkreFAIL (1/6)✗MarksFAIL (1/5)✗AckmanFAIL (1/9)✓TempletonPASS (4/8)✗SleepFAIL (1/6)•AsnessNEUTRAL (Not ranked)✗NeffFAIL (0/6)•SchlossNEUTRAL (4/7)•OshaughnessyNEUTRAL (Not ranked) - Debt & Leverage42% pass✓ 8✗ 7▾
7 of 12 flag NIKI's debt & leverage — Graham, Buffett, Lynch +4 more
LT Debt vs Net Current Assets✗GrahamLT Debt <= Net Current AssetsDebt/Equity & Interest CoverageD/E: 0.15, IC: N/A✗BuffettD/E < 0.5 AND Interest Coverage > 5xTotal Debt / Equity0.15✓Lynch< 0.33Cash - Long-term Debt✗LynchPositive preferredLT Debt / Total Assets Change0.00% -> 0.00%✓PiotroskiDecreased YoYCurrent Assets / Current Liabilities0.78✗Dreman> 1.5✗SchlossCurrent ratio >= 1.50x (app cutoff)Total Debt / Shareholders' Equity0.15✓Dreman< 0.8✓Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✓SchlossD/E < 1.00xDebt Levels0.15✓MungerDebt/Equity < 0.5✓AkreDebt/Equity < 0.3Interest Coverage & Debt/EBITDA✗MarksInterest Coverage > 3x; Debt/EBITDA < 4xTotal Debt / Shareholders Equity0.15✓Ackman<= 1.0Negative debt-to-equity (higher means less debt)-0.1479; #1496/4210 (top 35.5%)✗AsnessTop 30% of eligible cross-section
Business & financials
Financial snapshot: annual FY 2025. Current investor scores may use newer quarterly data.
Company Profile
Financial Snapshot
Shareholder Return
Fiscal 2025
Issued 34.8% of shares last year, 62.6% issued over two.
- Buybacks
- —
- Dividends
- —
Company Financials
Latest TTM and quarters alongside annual years
TTM sums four consecutive quarters and uses the latest quarter-end balances. Quarter columns show three-month results; annual columns show full-year totals. Growth compares the same period a year earlier. EPS is not added for TTM; full-year ratios are blank for quarters.
| Metric | FY 2025Sources
| FY 2024Sources
| FY 2023Sources
| FY 2022Sources
| FY 2021Sources
|
|---|---|---|---|---|---|
| Market Cap | $5.1Mcurrent | $6.3Mest. | $76.0Mest. | $178.5Mest. | $6.2Best. |
| Revenue | -- | -- | $431.4K↓67% | $1.3M↓16% | $1.5M |
| Operating Income | -- | -- | -$10.7M↑39% | -$17.5M↑9% | -$19.2M |
| Net Income | -$1.4M↑68% | -$4.3M↓51% | -$2.8M↑71% | -$9.8M↑61% | -$25.0M |
| EPS (Diluted) | $-0.19↑76% | $-0.78↓26% | $-0.62↑77% | $-2.75↓287% | $-0.71 |
| Gross Margin | — | — | 2.4%↓60% | 6.2%↑16% | 5.3% |
| Operating Margin | — | — | -2486.0%↓84% | -1351.1%↓8% | -1245.8% |
| ROE | -5.9%↑71% | -20.2%↓78% | -11.4%↑82% | -62.4%↑41% | -106.1% |
| Total Debt | $3.4M↑6% | $3.2M↑8% | $3.0M↓5% | $3.1M↑813% | $344.1K |
| Shareholders' Equity | $23.1M↑9% | $21.1M↓15% | $24.8M↑58% | $15.7M↓33% | $23.6M |
| Current Ratio | 0.78↑254% | 0.22↓81% | 1.18↑109% | 0.57↓80% | 2.90 |
| Debt / Equity | 0.15↓3% | 0.15↑27% | 0.12↓40% | 0.20↑1272% | 0.01 |
| Operating Cash Flow | -$1.8M↓54% | -$1.2M↑85% | -$7.7M↑37% | -$12.3M↑16% | -$14.7M |
| Free Cash Flow | -- | -- | -$7.7M↑38% | -$12.5M↑15% | -$14.8M |
Score history
Historical Score Timeline
Industry peers
Industry Peers
Similar companies in Measuring and Control Equipment
NIKI vs Peers — Financial Grading
| Company | Market Cap | Price | Revenue | Net Income | ROE | D/E | Op. Margin | Curr. Ratio | Graham | Buffett | Lynch | Greenblatt | Piotroski | Dreman |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| THERMO FISHER SCIENTIFIC INC.TMO | $259.4B | $700.22 | $44.6B | $6.7B | 12.6% | 0.74 | 17.4% | 1.89 | 3/9 | 3/9 | 3/7 | 1/3 | F-Score 5 | 7/11 |
| DANAHER CORP /DE/DHR | $163.9B | $233.02 | $24.6B | $3.6B | 6.9% | 0.35 | 19.1% | 1.87 | 3/9 | 4/9 | 2/7 | 1/3 | F-Score 5 | 4/11 |
| WATERS CORP /DE/WAT | $90.5B | $460.25 | $3.2B | $642.6M | 25.1% | 0.55 | 25.4% | 1.73 | 1/9 | 4/9 | 1/7 | 0/3 | F-Score 4 | 5/11 |
| AGILENT TECHNOLOGIES, INC.A | $49.0B | $173.96 | $6.9B | $1.3B | 19.3% | 0.45 | 21.3% | 1.96 | 2/9 | 5/9 | 3/7 | 1/3 | F-Score 5 | 5/11 |
| ROPER TECHNOLOGIES INCROP | $47.5B | $479.98 | $7.9B | $1.5B | 7.7% | 0.47 | 28.3% | 0.52 | 2/9 | 3/9 | 3/7 | 0/3 | F-Score 6 | 4/11 |
| COHERENT CORP.COHR | $43.0B | $218.15 | $5.8B | $49.4M | 0.9% | 0.69 | 1.6% | 2.19 | 3/9 | 1/9 | 0/7 | 0/3 | F-Score 4 | 4/11 |
| TERADYNE, INCTER | $39.0B | $249.55 | $3.2B | $554.0M | 19.8% | 0.07 | 20.4% | 1.75 | 2/9 | 6/9 | 4/7 | 1/3 | F-Score 6 | 6/11 |
| ILLUMINA, INC.ILMN | $31.3B | $207.01 | $4.3B | $850.0M | 31.2% | 0.73 | 18.6% | 2.08 | 2/9 | 1/9 | 3/7 | 1/3 | F-Score 8 | 5/11 |