Orchestra BioMed Holdings, Inc.

OBIO

Orchestra BioMed Holdings, Inc. operates as a biomedical company in the United States. The company's flagship product candidates include Atrioventricular Interval Modulation, a bioelectronic therapy candidate designed to immediately, substantially, and persistently lower blood pressure; and Virtue Sirolimus AngioInfusion Balloon for the treatment of atherosclerotic artery disease.

About the company

Country: United StatesPrice: $7.25Market Cap: $570.6M

Investment snapshot

6%positive consensus

Scored 1d ago

Positive

BUY / PASS

Neutral / negative

2 / 13

NEUTRAL / FAIL

Median fair value

—

No comparable estimates

Models with upside

0 / 17

Positive margin of safety

Strongest signal

9 of 12 pass — Buffett, Marks and Asness object

Key risk

No clean pass — all 16 investors flag at least one profitability criterion

Framework analysis

Verdict	Meaning
BUY	Positive purchase signal: the framework's buy requirements are met.
PASS	The company clears the framework's checklist or screen, but the framework does not produce a buy signal. For valuation frameworks this often means margin of safety is missing, insufficient, or unavailable; some screen-only frameworks have no intrinsic-value BUY state.
NEUTRAL	Neither a positive nor negative conclusion. It does not mean to hold an existing position.
FAIL	The company does not clear the framework's requirements.
Ranked	Ranked strategies do not use PASS: selected cohort is BUY, outside the cohort is FAIL, and unranked is NEUTRAL.

Current investor scores use trailing 12-month flows and the latest balance sheet where supported. Multi-year and EPS tests retain annual history; each framework shows its financial basis below. Intrinsic values use annual financials.

Metric	Graham Defensive Value	Buffett Quality Compounder	Lynch GARP	Greenblatt Magic Formula	Piotroski F-Score	Dreman Contrarian Value	Munger Quality Focus	Pabrai Dhandho Framework	Akre Three-Legged Stool	Marks Risk-Aware Value	Ackman Activist Value	Templeton Global Bargain Hunter	Sleep Scale Economies Shared	Asness Systematic Factors	Neff Low-P/E Total Return	Schloss Asset-Value Discipline	O'Shaughnessy Systematic Factor Composite
Verdict	FAIL	FAIL	FAIL	FAIL · Rank #2454 (Top 79.2%)	NEUTRAL	FAIL	PASS	FAIL	FAIL	FAIL	FAIL	FAIL	FAIL	FAIL	FAIL	FAIL	NEUTRAL
Score
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Intrinsic Value (annual)	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Margin of Safety	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Financial Basis	TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Annual history · FY 2025 Latest source filing: 2026-11-10 Score computed: 2026-11-14	Annual history · FY 2025 Latest source filing: 2026-03-12 Score computed: 2026-11-14	Annual history · FY 2025 · TTM ended 2026-09-30 vs 2025-09-30 · TTM ended 2026-09-30 Latest source filing: 2026-11-10 Score computed: 2026-11-14	Annual history · FY 2025 Latest source filing: 2026-03-12 Score computed: 2026-11-14	Annual history · FY 2025 Latest source filing: 2026-03-12 Score computed: 2026-11-14	Annual history · FY 2025 · TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Market data at 2026-11-01 Latest source filing: 2026-11-10 Score computed: 2026-11-14	Qualitative assessment · Annual history · FY 2025 Latest source filing: 2026-03-12 Score computed: 2026-11-14	Qualitative assessment · Annual history · FY 2025 Latest source filing: 2026-03-12 Score computed: 2026-11-14	Annual history · FY 2025 · Qualitative assessment · TTM ended 2026-09-30 Latest source filing: 2026-11-10 Score computed: 2026-11-14	Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-12 Score computed: 2026-11-14	Annual history · FY 2025 · TTM ended 2026-09-30 · Market data at 2026-11-01 Latest source filing: 2026-11-10 Score computed: 2026-11-14	Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 Latest source filing: 2026-03-12 Score computed: 2026-11-14	Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-12 Score computed: 2026-11-14	TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Price history 2025-01-01–2026-11-01 · Annual history · FY 2025 Latest source filing: 2026-11-10 Score computed: 2026-11-14	Annual history · FY 2025 · TTM ended 2026-09-30 Latest source filing: 2026-11-10 Score computed: 2026-11-14	Annual history · FY 2025 · Balance sheet at 2026-09-30 Latest source filing: 2026-11-10 Score computed: 2026-11-14	TTM ended 2026-09-30 · Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 Latest source filing: 2026-11-10 Score computed: 2026-11-14

Where It Passes

Debt & Leverage75% pass✓ 12✗ 3▾
9 of 12 pass — Buffett, Marks and Asness object
LT Debt vs Net Current AssetsLT Debt $15.0M vs NCA $91.2M
✓GrahamLT Debt <= Net Current Assets
Debt/Equity & Interest CoverageD/E: 0.28, IC: N/A
✗BuffettD/E < 0.5 AND Interest Coverage > 5x
Total Debt / Equity0.28
✓Lynch< 0.33
Cash - Long-term Debt$19.7M
✓LynchPositive preferred
LT Debt / Total Assets Change19.69% -> 13.06%
✓PiotroskiDecreased YoY
Current Assets / Current Liabilities7.25
✓Dreman> 1.5✓SchlossCurrent ratio >= 1.50x (app cutoff)
Total Debt / Shareholders' Equity0.28
✓Dreman< 0.8✓Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✓SchlossD/E < 1.00x
Debt Levels0.28
✓MungerDebt/Equity < 0.5✓AkreDebt/Equity < 0.3
Interest Coverage & Debt/EBITDA
✗MarksInterest Coverage > 3x; Debt/EBITDA < 4x
Total Debt / Shareholders Equity0.28
✓Ackman<= 1.0
Negative debt-to-equity (higher means less debt)-0.2800; #1944/4210 (top 46.2%)
✗AsnessTop 30% of eligible cross-section

Where It Falls Short

Profitability0% pass✓ 5✗ 30▾
No clean pass — all 16 investors flag at least one profitability criterion
Positive EPS (10 years)0/6 years positive
✗GrahamPositive EPS every year for 10 years
EPS Growth (3-yr avg, 10-yr window)N/A (negative base EPS)
✗Graham>= 33% growth
Net Income Positive (10+ years)0/6 years positive
✗BuffettPositive every year for 10+ years
ROE (up to 5-year arithmetic mean)-118.6%
✗Buffett> 15% arithmetic mean (app rule)
Operating Margin (10-yr trend)-154.7% (latest)
✓BuffettStable or rising over 10 years
Free Cash Flow Proxy$-52.7M
✗BuffettPositive and growing
Earnings Variance (10-yr CoV)N/A (negative mean EPS)
✗BuffettCoV < 0.3
Retained Earnings Effectiveness
✗Buffett$1 retained -> > $1 market value created
Basic earnings-growth PEG (dividends excluded)
✗Lynch< 1.0 (ideally < 0.5)
3-5 Year EPS CAGR
✗Lynch15-30% (Fast Grower); > 0% to pass
ROE-731.8%
✗Lynch> 15%
EBIT / Enterprise Value-9.4%
✗Greenblatt> 10%
Earnings Yield + ROC AssessmentEY=-9.4%, ROC=-89.0%
✗GreenblattBoth EY > 10% and ROC > 25%
Net Income / Total Assets-45.88%
✗PiotroskiROA > 0
ROA Change YoY-80.11% -> -45.88% (delta: +34.23%)
✓PiotroskiCurrent ROA > Prior ROA
(CFO / Total Assets) vs ROACFO/Assets=-42.63%, ROA=-45.88%
✓PiotroskiCFO/Assets > ROA
Gross Margin Change YoY92.3% -> 99.4%
✓PiotroskiImproved YoY
Pre-Tax Income / Revenue
✗Dreman>= 8%
Net Income / Shareholders' Equity-731.8%
✗Dreman> 12%
Margin of SafetyP/B=7.7x
✗PabraiP/B < 1.5 or P/E < 15
Return on Equity-118.6% (3-yr avg)
✗AkreROE > 20% (3-year avg)
Discount to Intrinsic ValueN/A (negative normalized EPS)
✗Marks>= 20% below intrinsic value
Positive Net Income Frequency0/5 years positive
✗MarksPositive net income in >= 7 of last 10 years
Operating Income / Revenue-195.4%
✗Ackman>= 15%
Net Income / Shareholders Equity-731.8%
✗Ackman>= 15%
5-Year EPS CAGR
✗Templeton> 0% (5-year EPS CAGR)
Operating Margin Trend-1866.2% (2023) -> -154.7% (2025)
✓TempletonNon-negative operating-margin trend over 3 years
Revenue growth vs. gross and operating margin trendgross margin 93.3% -> 99.4%, operating margin -1866.2% -> -154.7%
✗SleepRevenue rising; gross margin flat or falling; operating margin holding
Net income / market capitalization-9.98%; #4181/6340 (top 65.9%)
✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
Gross profit / total assets+28.99%; #1490/3702 (top 40.2%)
✗AsnessTop 30% of eligible cross-section
Net income / positive book equity-731.83%; #5125/5226 (top 98.1%)
✗AsnessTop 30% of eligible cross-section
Negative 5-year standard deviation of ROA-0.2588; #4478/5884 (top 76.1%)
✗AsnessTop 30% of eligible cross-section
3-5 Year Diluted EPS CAGR
✗Neff7%-20% annualized
Positive Diluted-EPS Years0/5 years positive
✗Schloss>= 70% positive over 5-10 observed years (app rule)
Valuation0% pass✓ 1✗ 27▾
No clean pass — all 13 investors flag at least one valuation criterion
Price / 3-yr avg EPS
✗Graham<= 15x
Price-to-Book Ratio7.7x
✗Graham<= 1.5x
P/E x P/B
✗Graham<= 22.5
Basic earnings-growth PEG (dividends excluded)
✗Lynch< 1.0 (ideally < 0.5)
EBIT / Enterprise Value-9.4%
✗Greenblatt> 10%
Earnings Yield + ROC AssessmentEY=-9.4%, ROC=-89.0%
✗GreenblattBoth EY > 10% and ROC > 25%
Price / EPS
✗Dreman< 12x✗Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)
Price / (CFO / Shares)N/A (negative CFPS)
✗Dreman< 8x
Price / Book Value per Share7.7x
✗Dreman< 1.2x✗Templeton< 1.5x✗SchlossP/B <= 0.80x (app cutoff)
Valuation ReasonablenessOE Yield=-12.8%
✗MungerP/E < 25 or Owner Earnings Yield > 5%
P/E or FCF YieldFCF Yield=-8.7%
✗PabraiP/E < 15 or FCF Yield > 10%
P/B or P/E vs. Historical AverageP/B=7.7x
✗MarksP/E < 15 or P/B < 2.0
Discount to Intrinsic ValueN/A (negative normalized EPS)
✗Marks>= 20% below intrinsic value
Price / FCF per ShareN/A (negative FCF)
✗Ackman<= 25
Price vs. Trailing Low292% of trailing low ($2.48)
✗Templeton<= 120% of trailing low (certified split-adjusted live window)
Net income / market capitalization-9.98%; #4181/6340 (top 65.9%)
✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
Positive book equity / market capitalization+0.0136; #5166/6449 (top 80.1%)
✗AsnessTop 30% of eligible cross-section
Price / Diluted EPS
✗NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)
(EPS CAGR % + Dividend Yield %) / P/E
✗Neff> 0.7 (Neff's published traditional edge)
Price / Tangible Book Value per Share7.72x
✗SchlossP/TBV <= 1.00x (app cutoff)
Book Value per Share Change
✗SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)
Revenue / market capitalization+0.0547; #4550/5247 (top 86.7%)
✗OshaughnessyTop 10% of eligible cross-section
(Operating cash flow - capex) / market capitalization-11.25%; #3279/4519 (top 72.6%)
✗OshaughnessyTop 10% of eligible cross-section
Trailing six-month price return through the evaluation date+81.70%; #418/6202 (top 6.7%)
✓OshaughnessyTop 10% of eligible cross-section
Cash Flow0% pass✓ 1✗ 11▾
No clean pass — all 10 investors flag at least one cash flow criterion
Free Cash Flow Proxy$-52.7M
✗BuffettPositive and growing
FCF Positive and Growing$-64.2M
✗LynchPositive and growing
Operating Cash Flow$-49.0M
✗PiotroskiCFO > 0
(CFO / Total Assets) vs ROACFO/Assets=-42.63%, ROA=-45.88%
✓PiotroskiCFO/Assets > ROA
Price / (CFO / Shares)N/A (negative CFPS)
✗Dreman< 8x
P/E or FCF YieldFCF Yield=-8.7%
✗PabraiP/E < 15 or FCF Yield > 10%
FCF Positive0/4 years FCF positive
✗MarksPositive FCF in majority of recent years
(OCF - CapEx) / Market Cap-15.5%
✗Ackman>= 4%
Price / FCF per ShareN/A (negative FCF)
✗Ackman<= 25
Positive Operating Cash Flow frequency0/5 years positive
✗SleepPositive OCF in >= 70% of available years
Operating Cash Flow - Capital Expenditures$-64.2M
✗Neff> $0 (app proxy for a strong fundamental case)
(Operating cash flow - capex) / market capitalization-11.25%; #3279/4519 (top 72.6%)
✗OshaughnessyTop 10% of eligible cross-section
Growth0% pass✓ 1✗ 12▾
No clean pass — all 8 investors flag at least one growth criterion
EPS Growth (3-yr avg, 10-yr window)N/A (negative base EPS)
✗Graham>= 33% growth
Basic earnings-growth PEG (dividends excluded)
✗Lynch< 1.0 (ideally < 0.5)
3-5 Year EPS CAGR
✗Lynch15-30% (Fast Grower); > 0% to pass
Inventory Growth vs Revenue GrowthInv: -39.5% vs Rev: 1007.4%
✓LynchInventory growth < Revenue growth
EPS Growth Direction$-0.02 (2021) -> $-1.11 (2025)
✗DremanPositive over recent years
EPS CAGR
✗Dreman> 5% annualized
Positive Net Income Frequency0/5 years positive
✗MarksPositive net income in >= 7 of last 10 years
3yr Median Revenue Growth-4.4%
✗Ackman>= 5%
Positive EPS Growth Frequency1/4 years with positive EPS growth
✗AckmanPositive EPS growth in >= 3 of last 5 years
5-Year EPS CAGR
✗Templeton> 0% (5-year EPS CAGR)
Revenue growth vs. gross and operating margin trendgross margin 93.3% -> 99.4%, operating margin -1866.2% -> -154.7%
✗SleepRevenue rising; gross margin flat or falling; operating margin holding
5-year Revenue CAGR
✗SleepCAGR > 7%
3-5 Year Diluted EPS CAGR
✗Neff7%-20% annualized
Verdicts7% pass✓ 1✗ 14▾
Split decision: 13 FAIL · 2 NEUTRAL · 1 PASS
Overall verdict
✗GrahamFAIL (2/9)✗BuffettFAIL (1/9)✗LynchFAIL (3/7)✗GreenblattRank #2454•PiotroskiNEUTRAL (F-Score 6)✗DremanFAIL (2/11)✓MungerPASS (2/4)✗PabraiFAIL (0/3)✗AkreFAIL (2/6)✗MarksFAIL (0/5)✗AckmanFAIL (1/9)✗TempletonFAIL (3/8)✗SleepFAIL (1/6)✗AsnessFAIL (Rank #1945/2370 (Top 82.1%))✗NeffFAIL (1/6)✗SchlossFAIL (2/7)•OshaughnessyNEUTRAL (Not ranked)
Efficiency38% pass✓ 4✗ 7▾
5 of 8 flag OBIO's efficiency — Buffett, Greenblatt, Munger +2 more
Current Ratio7.25
✓Graham>= 2.0
ROIC (3-5 yr avg)-159.2%
✗Buffett> 10%
ROIC - WACC-169.2%
✗BuffettPositive (WACC = 10%)
EBIT / (NWC + Net Fixed Assets)-89.0%
✗Greenblatt> 25%
Current Ratio Change YoY4.27 -> 6.45
✓PiotroskiIncreased YoY
Revenue / Total Assets Change YoY0.03x -> 0.29x
✓PiotroskiImproved YoY
Current Assets / Current Liabilities7.25
✓Dreman> 1.5
Return on Invested Capital-59.7%
✗Munger> 15%
ROIC (high and growing)FY2023: ROIC=unavailable; FY2024: ROIC=-105.9%; FY2025: ROIC=-59.7%
✗AkreLatest 3 consecutive FYs: ROIC > 15% in each
Reinvestment Rate x ROICN/A (non-positive net income)
✗AkreReinvestment Rate * ROIC > 10%
ROIC (5-year)0/2 years above 12% (latest -59.7%)
✗SleepROIC > 12% in a majority of years

Business & financials

Financial snapshot: annual FY 2025. Current investor scores may use newer quarterly data.

Company Profile

Industry: Medical Equipment

SIC Sector: Measuring & Medical Instruments

Size: Small Cap($570.6M)

Revenue: $33.5M+1169.2% YoY

Net Income: $52.7M+13.6% YoY

Financial Snapshot

Operating Margin-154.7%

Return on Equity-98.4%

Debt / Equity0.28

Current Ratio6.45

EPS (Diluted)$-1.11

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Company Financials

Latest TTM and quarters alongside annual years

TTM sums four consecutive quarters and uses the latest quarter-end balances. Quarter columns show three-month results; annual columns show full-year totals. Growth compares the same period a year earlier. EPS is not added for TTM; full-year ratios are blank for quarters.

The latest annual period end is unavailable. Showing the latest fiscal cycle’s quarters; quarter and annual columns may overlap. Quarterly shows the full quarter history.

Metric	TTM · 2026-09-30 2025-10-01 – 2026-09-30 Sources · derived quarter values 10-K · 2026-03-12 10-Q · 2026-05-12 10-Q · 2026-08-10 10-Q · 2026-11-10 Derived from cumulative filings: revenue, net income, operating income, ebit, operating cash flow, depreciation amortization, capex.	Q3 FY 2026 2026-07-01 – 2026-09-30 Sources · derived quarter values 10-Q · 2026-11-10 Derived from cumulative filings: operating cash flow, depreciation amortization, capex.	Q2 FY 2026 2026-04-01 – 2026-06-30 Sources · derived quarter values 10-Q · 2026-08-10 Derived from cumulative filings: operating cash flow, depreciation amortization, capex.	Q1 FY 2026 2026-01-01 – 2026-03-31 Sources 10-Q · 2026-05-12	FY 2025 Sources 10-K · 2026-03-12	FY 2024 Sources 10-K · 2025-03-31	FY 2023 Sources 10-K · 2024-03-27	FY 2022 Sources 10-K · 2023-01-25	FY 2021 Sources 10-K · 2022-03-31
Market Cap	$570.6Mcurrent	--	--	--	$199.0Mest.	$200.8Mest.	$253.3Mest.	--	$201.6Mest.
Revenue	$31.2M↑1007%	$91.0K↓89%	$88.0K↓89%	$110.0K↓87%	$33.5M↑1169%	$2.6M↓4%	$2.8M↓22%	$3.5M	--
Operating Income	-$61.0M↑19%	-$23.3M↓15%	-$22.4M↓16%	-$22.1M↓17%	-$51.8M↑19%	-$64.3M↓25%	-$51.5M↓58%	-$32.7M↓8173%	-$394.8K
Net Income	-$57.0M↑24%	-$18.8M↑10%	-$23.8M↓23%	-$20.7M↓10%	-$52.7M↑14%	-$61.0M↓24%	-$49.1M↓46%	-$33.6M↓8773%	-$378.8K
EPS (Diluted)	--	$-0.30↑25%	$-0.38↑24%	$-0.33↑33%	$-1.11↑33%	$-1.66↓12%	$-1.48↓771%	$-0.17↓750%	$-0.02
Gross Margin	—	—	—	—	99.4%↑8%	92.3%↓1%	93.3%↓1%	94.0%	—
Operating Margin	-195.4%↑93%	-25600.0%↓985%	-25404.5%↓999%	-20069.1%↓821%	-154.7%↑94%	-2437.5%↓31%	-1866.2%↓102%	-924.3%	—
ROE	-731.8%↓326%	—	—	—	-98.4%↑47%	-185.2%↓156%	-72.2%↓115%	483.9%↑4937%	9.6%
Total Debt	--	--	--	$15.0M	$15.0M	$15.0M	--	--	--
Shareholders' Equity	$7.8M↓82%	$7.8M↓82%	$19.3M↑6450%	$41.2M↑144%	$53.6M↑63%	$33.0M↓52%	$68.0M↑1080%	-$6.9M↓76%	-$3.9M
Current Ratio	7.25↑53%	7.25↑53%	8.26↑293%	7.03↑110%	6.45↑51%	4.27↓46%	7.95↑74%	4.56↓58%	10.88
Debt / Equity	—	—	—	0.36↓59%	0.28↓38%	0.46	—	—	—
Operating Cash Flow	-$63.3M↓5%	-$19.5M↓34%	-$19.3M↓25%	-$22.2M↓33%	-$49.0M↑3%	-$50.6M↓10%	-$46.1M↓57%	-$29.3M↓10654%	-$272.4K
Free Cash Flow	-$64.2M↓6%	-$19.9M↓34%	-$19.6M↓26%	-$22.4M↓34%	-$49.5M↑3%	-$50.8M↓10%	-$46.2M↓55%	-$29.9M	--

Score history

Historical Score Timeline

Industry peers

Industry Peers

Similar companies in Medical Equipment

OBIO vs Peers — Financial Grading

Revenue$33.5MBottom 25%

Net Income$52.7MBottom 25%

ROE-98.4%Bottom 25%

D/E0.28Median

Op. Margin-154.7%Bottom 25%

Curr. Ratio6.45Top 25%

Company	Market Cap	Price	Revenue	Net Income	ROE	D/E	Op. Margin	Curr. Ratio	Graham	Buffett	Lynch	Greenblatt	Piotroski	Dreman
ALCON INCALC	$35.6B	$74.12	$10.4B	$980.0M	4.4%	0.21	13.1%	2.12	2/9	1/9	3/7	0/3	F-Score 6	4/11
KONINKLIJKE PHILIPS NVPHG	$29.7B	$30.34	$21.0B	$1.1B	8.2%	0.64	8.0%	1.32	1/9	1/9	1/7	0/3	F-Score 5	3/11
WEST PHARMACEUTICAL SERVICES INCWST	$29.0B	$416.42	$3.1B	$493.7M	15.5%	0.06	19.0%	3.02	4/9	6/9	6/7	1/3	F-Score 7	5/11
SMITH & NEPHEW PLCSNN	$13.1B	$31.28	$6.2B	$625.0M	11.8%	0.59	12.9%	2.57	2/9	0/9	1/7	0/3	F-Score 6	4/11
MSA Safety IncMSA	$6.7B	$174.17	$1.9B	$278.9M	20.4%	0.42	19.8%	3.01	5/9	5/9	4/7	1/3	F-Score 5	7/11
STAAR SURGICAL COSTAA	$1.3B	$26.39	$239.4M	$80.4M	-23.4%	—	-38.3%	4.55	2/9	2/9	2/7	0/3	F-Score 3	3/11
ARTIVION, INC.AORT	$931.9M	$19.10	$441.3M	$9.8M	2.2%	0.48	7.6%	3.53	2/9	0/9	0/7	0/3	F-Score 7	1/11
InMode Ltd.INMD	$763.6M	$13.27	$370.5M	$93.8M	13.7%	—	23.0%	9.88	5/9	3/9	0/7	3/3	F-Score 4	4/11