10x Genomics, Inc.

Where It Passes

Where It Falls Short

• Profitability0% pass✓ 6✗ 29▾

  No clean pass — all 16 investors flag at least one profitability criterion

  Positive EPS (10 years)0/10 years positive

  ✗GrahamPositive EPS every year for 10 years

  EPS Growth (3-yr avg, 10-yr window)N/A (negative base EPS)

  ✗Graham>= 33% growth

  Net Income Positive (10+ years)0/10 years positive

  ✗BuffettPositive every year for 10+ years

  ROE (up to 5-year arithmetic mean)-18.7%

  ✗Buffett> 15% arithmetic mean (app rule)

  Operating Margin (10-yr trend)-9.5% (latest)

  ✓BuffettStable or rising over 10 years

  Free Cash Flow Proxy$-13.3M

  ✗BuffettPositive and growing

  Earnings Variance (10-yr CoV)N/A (negative mean EPS)

  ✗BuffettCoV < 0.3

  Retained Earnings Effectiveness

  ✗Buffett$1 retained -> > $1 market value created

  Basic earnings-growth PEG (dividends excluded)

  ✗Lynch< 1.0 (ideally < 0.5)

  3-5 Year EPS CAGR

  ✗Lynch15-30% (Fast Grower); > 0% to pass

  ROE-8.0%

  ✗Lynch> 15%

  EBIT / Enterprise Value-0.8%

  ✗Greenblatt> 10%

  Earnings Yield + ROC AssessmentEY=-0.8%, ROC=-21.5%

  ✗GreenblattBoth EY > 10% and ROC > 25%

  Net Income / Total Assets-4.18%

  ✗PiotroskiROA > 0

  ROA Change YoY-19.88% -> -4.18% (delta: +15.70%)

  ✓PiotroskiCurrent ROA > Prior ROA

  (CFO / Total Assets) vs ROACFO/Assets=13.06%, ROA=-4.18%

  ✓PiotroskiCFO/Assets > ROA

  Gross Margin Change YoY67.9% -> 69.1%

  ✓PiotroskiImproved YoY

  Pre-Tax Income / Revenue-10.5%

  ✗Dreman>= 8%

  Net Income / Shareholders' Equity-8.0%

  ✗Dreman> 12%

  Margin of SafetyP/B=9.3x

  ✗PabraiP/B < 1.5 or P/E < 15

  Return on Equity-21.9% (3-yr avg)

  ✗AkreROE > 20% (3-year avg)

  Discount to Intrinsic ValueN/A (negative normalized EPS)

  ✗Marks>= 20% below intrinsic value

  Positive Net Income Frequency0/9 years positive

  ✗MarksPositive net income in >= 7 of last 10 years

  Operating Income / Revenue-11.7%

  ✗Ackman>= 15%

  Net Income / Shareholders Equity-8.0%

  ✗Ackman>= 15%

  5-Year EPS CAGR

  ✗Templeton> 0% (5-year EPS CAGR)

  Operating Margin Trend-42.9% (2023) -> -9.5% (2025)

  ✓TempletonNon-negative operating-margin trend over 3 years

  Revenue growth vs. gross and operating margin trendgross margin 66.2% -> 69.1%, operating margin -42.9% -> -9.5%

  ✗SleepRevenue rising; gross margin flat or falling; operating margin holding

  Net income / market capitalization-0.88%; #3386/6340 (top 53.4%)

  ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section

  Gross profit / total assets+41.82%; #900/3702 (top 24.3%)

  ✓AsnessTop 30% of eligible cross-section

  Net income / positive book equity-8.00%; #3332/5226 (top 63.8%)

  ✗AsnessTop 30% of eligible cross-section

  Negative 5-year standard deviation of ROA-0.0846; #3278/5884 (top 55.7%)

  ✗AsnessTop 30% of eligible cross-section

  3-5 Year Diluted EPS CAGR

  ✗Neff7%-20% annualized

  Positive Diluted-EPS Years0/9 years positive

  ✗Schloss>= 70% positive over 5-10 observed years (app rule)
• Valuation0% pass✓ 1✗ 27▾

  No clean pass — all 13 investors flag at least one valuation criterion

  Price / 3-yr avg EPS

  ✗Graham<= 15x

  Price-to-Book Ratio9.3x

  ✗Graham<= 1.5x

  P/E x P/B

  ✗Graham<= 22.5

  Basic earnings-growth PEG (dividends excluded)

  ✗Lynch< 1.0 (ideally < 0.5)

  EBIT / Enterprise Value-0.8%

  ✗Greenblatt> 10%

  Earnings Yield + ROC AssessmentEY=-0.8%, ROC=-21.5%

  ✗GreenblattBoth EY > 10% and ROC > 25%

  Price / EPS

  ✗Dreman< 12x✗Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)

  Price / (CFO / Shares)54.6x

  ✗Dreman< 8x

  Price / Book Value per Share9.3x

  ✗Dreman< 1.2x✗Templeton< 1.5x✗SchlossP/B <= 0.80x (app cutoff)

  Valuation ReasonablenessOE Yield=-0.2%

  ✗MungerP/E < 25 or Owner Earnings Yield > 5%

  P/E or FCF YieldFCF Yield=1.7%

  ✗PabraiP/E < 15 or FCF Yield > 10%

  P/B or P/E vs. Historical AverageP/B=9.3x

  ✗MarksP/E < 15 or P/B < 2.0

  Discount to Intrinsic ValueN/A (negative normalized EPS)

  ✗Marks>= 20% below intrinsic value

  Price / FCF per Share57.1x

  ✗Ackman<= 25

  Price vs. Trailing Low704% of trailing low ($8.27)

  ✗Templeton<= 120% of trailing low (certified split-adjusted live window)

  Net income / market capitalization-0.88%; #3386/6340 (top 53.4%)

  ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section

  Positive book equity / market capitalization+0.1095; #4695/6449 (top 72.8%)

  ✗AsnessTop 30% of eligible cross-section

  Price / Diluted EPS

  ✗NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)

  (EPS CAGR % + Dividend Yield %) / P/E

  ✗Neff> 0.7 (Neff's published traditional edge)

  Price / Tangible Book Value per Share10.19x

  ✗SchlossP/TBV <= 1.00x (app cutoff)

  Book Value per Share Change-8.5%

  ✗SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)

  Revenue / market capitalization+0.0808; #4426/5247 (top 84.4%)

  ✗OshaughnessyTop 10% of eligible cross-section

  (Operating cash flow - capex) / market capitalization+1.23%; #2368/4519 (top 52.4%)

  ✗OshaughnessyTop 10% of eligible cross-section

  Trailing six-month price return through the evaluation date+150.06%; #209/6202 (top 3.4%)

  ✓OshaughnessyTop 10% of eligible cross-section
• Valuation models0% pass✗ 2▾

  TXG overvalued: all 2 models price fair value below $58.19 (median $18.13)

  Munger fair value$18.56

  ✗Munger-213.5% margin vs $58.19

  Ackman fair value$17.69

  ✗Ackman-228.9% margin vs $58.19
• Debt & Leverage8% pass✓ 3✗ 12▾

  11 of 12 flag TXG's debt & leverage — Graham, Buffett, Lynch +8 more

  LT Debt vs Net Current Assets

  ✗GrahamLT Debt <= Net Current Assets

  Debt/Equity & Interest Coverage

  ✗BuffettD/E < 0.5 AND Interest Coverage > 5x

  Total Debt / Equity

  ✗Lynch< 0.33

  Cash - Long-term Debt

  ✗LynchPositive preferred

  LT Debt / Total Assets Change0.00% -> 0.00%

  ✓PiotroskiDecreased YoY

  Current Assets / Current Liabilities5.12

  ✓Dreman> 1.5✓SchlossCurrent ratio >= 1.50x (app cutoff)

  Total Debt / Shareholders' Equity

  ✗Dreman< 0.8✗Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✗SchlossD/E < 1.00x

  Debt Levels

  ✗MungerDebt/Equity < 0.5✗AkreDebt/Equity < 0.3

  Interest Coverage & Debt/EBITDA

  ✗MarksInterest Coverage > 3x; Debt/EBITDA < 4x

  Total Debt / Shareholders Equity

  ✗Ackman<= 1.0

  Negative debt-to-equity (higher means less debt)

  ✗AsnessTop 30% of eligible cross-section
• Growth13% pass✓ 3✗ 10▾

  7 of 8 flag TXG's growth — Graham, Lynch, Dreman +4 more

  EPS Growth (3-yr avg, 10-yr window)N/A (negative base EPS)

  ✗Graham>= 33% growth

  Basic earnings-growth PEG (dividends excluded)

  ✗Lynch< 1.0 (ideally < 0.5)

  3-5 Year EPS CAGR

  ✗Lynch15-30% (Fast Grower); > 0% to pass

  Inventory Growth vs Revenue GrowthInv: 4.3% vs Rev: -3.6%

  ✗LynchInventory growth < Revenue growth

  EPS Growth Direction$-1.62 (2017) -> $-0.35 (2025)

  ✗DremanPositive over recent years

  EPS CAGR

  ✗Dreman> 5% annualized

  Positive Net Income Frequency0/9 years positive

  ✗MarksPositive net income in >= 7 of last 10 years

  3yr Median Revenue Growth5.2%

  ✓Ackman>= 5%

  Positive EPS Growth Frequency3/5 years with positive EPS growth

  ✓AckmanPositive EPS growth in >= 3 of last 5 years

  5-Year EPS CAGR

  ✗Templeton> 0% (5-year EPS CAGR)

  Revenue growth vs. gross and operating margin trendgross margin 66.2% -> 69.1%, operating margin -42.9% -> -9.5%

  ✗SleepRevenue rising; gross margin flat or falling; operating margin holding

  5-year Revenue CAGR16.6%

  ✓SleepCAGR > 7%

  3-5 Year Diluted EPS CAGR

  ✗Neff7%-20% annualized
• Verdicts13% pass✓ 2✗ 13▾

  Split decision: 12 FAIL · 2 PASS · 2 NEUTRAL

  Overall verdict

  ✗GrahamFAIL (2/9)✗BuffettFAIL (1/9)✗LynchFAIL (1/7)✗GreenblattRank #1992✓PiotroskiPASS (F-Score 5)✗DremanFAIL (2/11)✗MungerFAIL (0/4)✗PabraiFAIL (0/3)✗AkreFAIL (1/6)✗MarksFAIL (0/5)✓AckmanPASS (4/9)✗TempletonFAIL (2/8)✗SleepFAIL (2/6)•AsnessNEUTRAL (Not ranked)✗NeffFAIL (2/6)✗SchlossFAIL (1/7)•OshaughnessyNEUTRAL (Not ranked)
• Efficiency25% pass✓ 2✗ 9▾

  6 of 8 flag TXG's efficiency — Buffett, Greenblatt, Piotroski +3 more

  Current Ratio5.12

  ✓Graham>= 2.0

  ROIC (3-5 yr avg)-326.7%

  ✗Buffett> 10%

  ROIC - WACC-336.7%

  ✗BuffettPositive (WACC = 10%)

  EBIT / (NWC + Net Fixed Assets)-21.5%

  ✗Greenblatt> 25%

  Current Ratio Change YoY4.97 -> 4.46

  ✗PiotroskiIncreased YoY

  Revenue / Total Assets Change YoY0.66x -> 0.62x

  ✗PiotroskiImproved YoY

  Current Assets / Current Liabilities5.12

  ✓Dreman> 1.5

  Return on Invested Capital

  ✗Munger> 15%

  ROIC (high and growing)FY2023: ROIC=unavailable; FY2024: ROIC=unavailable; FY2025: ROIC=unavailable

  ✗AkreLatest 3 consecutive FYs: ROIC > 15% in each

  Reinvestment Rate x ROIC

  ✗AkreReinvestment Rate * ROIC > 10%

  ROIC (5-year)

  ✗SleepROIC > 12% in a majority of years
• Cash Flow30% pass✓ 4✗ 8▾

  7 of 10 flag TXG's cash flow — Buffett, Dreman, Pabrai +4 more

  Free Cash Flow Proxy$-13.3M

  ✗BuffettPositive and growing

  FCF Positive and Growing$93.8M

  ✓LynchPositive and growing

  Operating Cash Flow$136.1M

  ✓PiotroskiCFO > 0

  (CFO / Total Assets) vs ROACFO/Assets=13.06%, ROA=-4.18%

  ✓PiotroskiCFO/Assets > ROA

  Price / (CFO / Shares)54.6x

  ✗Dreman< 8x

  P/E or FCF YieldFCF Yield=1.7%

  ✗PabraiP/E < 15 or FCF Yield > 10%

  FCF Positive1/9 years FCF positive

  ✗MarksPositive FCF in majority of recent years

  (OCF - CapEx) / Market Cap1.3%

  ✗Ackman>= 4%

  Price / FCF per Share57.1x

  ✗Ackman<= 25

  Positive Operating Cash Flow frequency3/9 years positive

  ✗SleepPositive OCF in >= 70% of available years

  Operating Cash Flow - Capital Expenditures$93.8M

  ✓Neff> $0 (app proxy for a strong fundamental case)

  (Operating cash flow - capex) / market capitalization+1.23%; #2368/4519 (top 52.4%)

  ✗OshaughnessyTop 10% of eligible cross-section