Cellectis S.A.
CLLSAbout the company
Cellectis S.A., a clinical stage biotechnological company, develops products based on gene-editing with a portfolio of allogeneic chimeric antigen receptor T-cells product candidates in the field of immuno-oncology and gene therapy product candidates in other therapeutic indications.
Investment snapshot
Positive
1
BUY / PASS
Neutral / negative
1 / 14
NEUTRAL / FAIL
Median fair value
—
No comparable estimates
Models with upside
0 / 17
Positive margin of safety
Key risk
No clean pass — all 16 investors flag at least one profitability criterion
Framework analysis
| Verdict | Meaning |
|---|---|
| BUY | Positive purchase signal: the framework's buy requirements are met. |
| PASS | The company clears the framework's checklist or screen, but the framework does not produce a buy signal. For valuation frameworks this often means margin of safety is missing, insufficient, or unavailable; some screen-only frameworks have no intrinsic-value BUY state. |
| NEUTRAL | Neither a positive nor negative conclusion. It does not mean to hold an existing position. |
| FAIL | The company does not clear the framework's requirements. |
| Ranked | Ranked strategies do not use PASS: selected cohort is BUY, outside the cohort is FAIL, and unranked is NEUTRAL. |
Current investor scores use trailing 12-month flows and the latest balance sheet where supported. Multi-year and EPS tests retain annual history; each framework shows its financial basis below. Intrinsic values use annual financials.
| Metric | Graham Defensive Value | Buffett Quality Compounder | Lynch GARP | Greenblatt Magic Formula | Piotroski F-Score | Dreman Contrarian Value | Munger Quality Focus | Pabrai Dhandho Framework | Akre Three-Legged Stool | Marks Risk-Aware Value | Ackman Activist Value | Templeton Global Bargain Hunter | Sleep Scale Economies Shared | Asness Systematic Factors | Neff Low-P/E Total Return | Schloss Asset-Value Discipline | O'Shaughnessy Systematic Factor Composite |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Verdict | FAIL | FAIL | FAIL | Not ranked | FAIL | FAIL | FAIL | FAIL | FAIL | FAIL | FAIL | PASS | FAIL | FAIL | FAIL | FAIL | NEUTRAL |
| Score | |||||||||||||||||
| Analysis | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… |
| Intrinsic Value (annual) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Margin of Safety | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Financial Basis | Annual history · FY 2025 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 · Market data at 2026-11-01 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Qualitative assessment · Annual history · FY 2025 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Qualitative assessment · Annual history · FY 2025 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 · Market data at 2026-11-01 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-20 Score computed: 2026-11-14 | Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 Latest source filing: 2026-03-20 Score computed: 2026-11-14 |
Where It Passes
Where It Falls Short
- Profitability0% pass✓ 2✗ 33▾
No clean pass — all 16 investors flag at least one profitability criterion
Positive EPS (10 years)0/12 years positive✗GrahamPositive EPS every year for 10 yearsEPS Growth (3-yr avg, 10-yr window)✗Graham>= 33% growthNet Income Positive (10+ years)0/12 years positive✗BuffettPositive every year for 10+ yearsROE (up to 5-year arithmetic mean)-79.6%✗Buffett> 15% arithmetic mean (app rule)Operating Margin (10-yr trend)-45.3% (latest)✗BuffettStable or rising over 10 yearsFree Cash Flow Proxy$-49.9M✗BuffettPositive and growingEarnings Variance (10-yr CoV)✗BuffettCoV < 0.3Retained Earnings Effectiveness✗Buffett$1 retained -> > $1 market value createdBasic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)3-5 Year EPS CAGR✗Lynch15-30% (Fast Grower); > 0% to passROE-89.1%✗Lynch> 15%EBIT / Enterprise Value-35.7%✗Greenblatt> 10%Earnings Yield + ROC AssessmentEY=-35.7%, ROC=None✗GreenblattBoth EY > 10% and ROC > 25%Net Income / Total Assets-20.82%✗PiotroskiROA > 0ROA Change YoY-9.58% -> -20.82% (delta: -11.23%)✗PiotroskiCurrent ROA > Prior ROA(CFO / Total Assets) vs ROACFO/Assets=-12.13%, ROA=-20.82%✓PiotroskiCFO/Assets > ROAGross Margin Change YoY100.0% -> 100.0%✗PiotroskiImproved YoYPre-Tax Income / Revenue-93.2%✗Dreman>= 8%Net Income / Shareholders' Equity-89.1%✗Dreman> 12%Margin of SafetyP/B=1.6x✗PabraiP/B < 1.5 or P/E < 15Return on Equity-78.8% (3-yr avg)✗AkreROE > 20% (3-year avg)Discount to Intrinsic Value✗Marks>= 20% below intrinsic valuePositive Net Income Frequency0/12 years positive✗MarksPositive net income in >= 7 of last 10 yearsOperating Income / Revenue-45.3%✗Ackman>= 15%Net Income / Shareholders Equity-89.1%✗Ackman>= 15%5-Year EPS CAGR✗Templeton> 0% (5-year EPS CAGR)Operating Margin Trend-12887.7% (2023) -> -45.3% (2025)✓TempletonNon-negative operating-margin trend over 3 yearsRevenue growth vs. gross and operating margin trendgross margin 2.4% -> 100.0%, operating margin -12887.7% -> -45.3%✗SleepRevenue rising; gross margin flat or falling; operating margin holdingNet income / market capitalization-56.87%; #5120/6340 (top 80.8%)✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-sectionGross profit / total assets+22.47%; #1893/3702 (top 51.1%)✗AsnessTop 30% of eligible cross-sectionNet income / positive book equity-89.05%; #4531/5226 (top 86.7%)✗AsnessTop 30% of eligible cross-sectionNegative 5-year standard deviation of ROA-0.1220; #3720/5884 (top 63.2%)✗AsnessTop 30% of eligible cross-section3-5 Year Diluted EPS CAGR✗Neff7%-20% annualizedPositive Diluted-EPS Years0/10 years positive✗Schloss>= 70% positive over 5-10 observed years (app rule) - Valuation0% pass✓ 2✗ 26▾
No clean pass — all 13 investors flag at least one valuation criterion
Price / 3-yr avg EPS✗Graham<= 15xPrice-to-Book Ratio1.6x✗Graham<= 1.5xP/E x P/B✗Graham<= 22.5Basic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)EBIT / Enterprise Value-35.7%✗Greenblatt> 10%Earnings Yield + ROC AssessmentEY=-35.7%, ROC=None✗GreenblattBoth EY > 10% and ROC > 25%Price / EPS✗Dreman< 12x✗Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)Price / (CFO / Shares)N/A (negative CFPS)✗Dreman< 8xPrice / Book Value per Share1.6x✗Dreman< 1.2x✗Templeton< 1.5x✗SchlossP/B <= 0.80x (app cutoff)Valuation ReasonablenessOE Yield=-42.1%✗MungerP/E < 25 or Owner Earnings Yield > 5%P/E or FCF YieldFCF Yield=-35.1%✗PabraiP/E < 15 or FCF Yield > 10%P/B or P/E vs. Historical AverageP/B=1.6x✓MarksP/E < 15 or P/B < 2.0Discount to Intrinsic Value✗Marks>= 20% below intrinsic valuePrice / FCF per ShareN/A (negative FCF)✗Ackman<= 25Price vs. Trailing Low112% of trailing low ($1.05)✓Templeton<= 120% of trailing low (certified split-adjusted live window)Net income / market capitalization-56.87%; #5120/6340 (top 80.8%)✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-sectionPositive book equity / market capitalization+0.6385; #2390/6449 (top 37.1%)✗AsnessTop 30% of eligible cross-sectionPrice / Diluted EPS✗NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)(EPS CAGR % + Dividend Yield %) / P/E✗Neff> 0.7 (Neff's published traditional edge)Price / Tangible Book Value per Share1.57x✗SchlossP/TBV <= 1.00x (app cutoff)Book Value per Share Change✗SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)Revenue / market capitalization+0.6137; #2356/5247 (top 44.9%)✗OshaughnessyTop 10% of eligible cross-section(Operating cash flow - capex) / market capitalization-35.13%; #3727/4519 (top 82.5%)✗OshaughnessyTop 10% of eligible cross-sectionTrailing six-month price return through the evaluation date-67.13%; #5594/6202 (top 90.2%)✗OshaughnessyTop 10% of eligible cross-section - Cash Flow0% pass✓ 1✗ 11▾
No clean pass — all 10 investors flag at least one cash flow criterion
Free Cash Flow Proxy$-49.9M✗BuffettPositive and growingFCF Positive and Growing$-41.8M✗LynchPositive and growingOperating Cash Flow$-39.4M✗PiotroskiCFO > 0(CFO / Total Assets) vs ROACFO/Assets=-12.13%, ROA=-20.82%✓PiotroskiCFO/Assets > ROAPrice / (CFO / Shares)N/A (negative CFPS)✗Dreman< 8xP/E or FCF YieldFCF Yield=-35.1%✗PabraiP/E < 15 or FCF Yield > 10%FCF Positive1/11 years FCF positive✗MarksPositive FCF in majority of recent years(OCF - CapEx) / Market Cap-35.3%✗Ackman>= 4%Price / FCF per ShareN/A (negative FCF)✗Ackman<= 25Positive Operating Cash Flow frequency2/11 years positive✗SleepPositive OCF in >= 70% of available yearsOperating Cash Flow - Capital Expenditures$-41.8M✗Neff> $0 (app proxy for a strong fundamental case)(Operating cash flow - capex) / market capitalization-35.13%; #3727/4519 (top 82.5%)✗OshaughnessyTop 10% of eligible cross-section - Growth0% pass✓ 3✗ 10▾
No clean pass — all 8 investors flag at least one growth criterion
EPS Growth (3-yr avg, 10-yr window)✗Graham>= 33% growthBasic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)3-5 Year EPS CAGR✗Lynch15-30% (Fast Grower); > 0% to passInventory Growth vs Revenue GrowthN/A (no inventory)✓LynchInventory growth < Revenue growthEPS Growth Direction✗DremanPositive over recent yearsEPS CAGR✗Dreman> 5% annualizedPositive Net Income Frequency0/12 years positive✗MarksPositive net income in >= 7 of last 10 years3yr Median Revenue Growth75.8%✓Ackman>= 5%Positive EPS Growth Frequency✗AckmanPositive EPS growth in >= 3 of last 5 years5-Year EPS CAGR✗Templeton> 0% (5-year EPS CAGR)Revenue growth vs. gross and operating margin trendgross margin 2.4% -> 100.0%, operating margin -12887.7% -> -45.3%✗SleepRevenue rising; gross margin flat or falling; operating margin holding5-year Revenue CAGR7.4%✓SleepCAGR > 7%3-5 Year Diluted EPS CAGR✗Neff7%-20% annualized - Efficiency0% pass✓ 1✗ 10▾
No clean pass — all 8 investors flag at least one efficiency criterion
Current Ratio✗Graham>= 2.0ROIC (3-5 yr avg)-83.0%✗Buffett> 10%ROIC - WACC-93.0%✗BuffettPositive (WACC = 10%)EBIT / (NWC + Net Fixed Assets)✗Greenblatt> 25%Current Ratio Change YoY✗PiotroskiIncreased YoYRevenue / Total Assets Change YoY0.11x -> 0.22x✓PiotroskiImproved YoYCurrent Assets / Current Liabilities✗Dreman> 1.5Return on Invested Capital-23.5%✗Munger> 15%ROIC (high and growing)FY2023: ROIC=-56.5%; FY2024: ROIC=-27.1%; FY2025: ROIC=-23.5%✗AkreLatest 3 consecutive FYs: ROIC > 15% in eachReinvestment Rate x ROICN/A (non-positive net income)✗AkreReinvestment Rate * ROIC > 10%ROIC (5-year)0/5 years above 12% (latest -23.5%)✗SleepROIC > 12% in a majority of years - Verdicts7% pass✓ 1✗ 14▾
Split decision: 14 FAIL · 1 PASS · 1 NEUTRAL
Overall verdict✗GrahamFAIL (0/9)✗BuffettFAIL (0/9)✗LynchFAIL (1/7)•GreenblattNot ranked✗PiotroskiFAIL (F-Score 3)✗DremanFAIL (1/11)✗MungerFAIL (1/4)✗PabraiFAIL (0/3)✗AkreFAIL (1/6)✗MarksFAIL (1/5)✗AckmanFAIL (3/9)✓TempletonPASS (4/8)✗SleepFAIL (2/6)✗AsnessFAIL (Rank #2259/2370 (Top 95.3%))✗NeffFAIL (1/6)✗SchlossFAIL (1/7)•OshaughnessyNEUTRAL (Not ranked) - Debt & Leverage33% pass✓ 6✗ 9▾
8 of 12 flag CLLS's debt & leverage — Graham, Buffett, Lynch +5 more
Debt Levels0.47✓MungerDebt/Equity < 0.5✗AkreDebt/Equity < 0.3LT Debt vs Net Current Assets✗GrahamLT Debt <= Net Current AssetsDebt/Equity & Interest CoverageD/E: 0.47, IC: -0.6x✗BuffettD/E < 0.5 AND Interest Coverage > 5xTotal Debt / Equity0.47✗Lynch< 0.33Cash - Long-term Debt✗LynchPositive preferredLT Debt / Total Assets Change0.00% -> 0.00%✓PiotroskiDecreased YoYCurrent Assets / Current Liabilities✗Dreman> 1.5✗SchlossCurrent ratio >= 1.50x (app cutoff)Total Debt / Shareholders' Equity0.47✓Dreman< 0.8✓Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✓SchlossD/E < 1.00xInterest Coverage & Debt/EBITDAIC=-0.6x, D/EBITDA=N/A✗MarksInterest Coverage > 3x; Debt/EBITDA < 4xTotal Debt / Shareholders Equity0.47✓Ackman<= 1.0Negative debt-to-equity (higher means less debt)-0.4667; #2402/4210 (top 57.1%)✗AsnessTop 30% of eligible cross-section
Business & financials
Financial snapshot: annual FY 2025. Current investor scores may use newer quarterly data.
Company Profile
Financial Snapshot
Shareholder Return
Fiscal 2025
Issued 0.2% of shares last year, 39.8% issued over two.
- Buybacks
- —
- Dividends
- —
Company Financials
Latest TTM and quarters alongside annual years
TTM sums four consecutive quarters and uses the latest quarter-end balances. Quarter columns show three-month results; annual columns show full-year totals. Growth compares the same period a year earlier. EPS is not added for TTM; full-year ratios are blank for quarters.
| Metric | FY 2025Sources
| FY 2024Sources
| FY 2023Sources
| FY 2022Sources
| FY 2021Sources
|
|---|---|---|---|---|---|
| Market Cap | $118.9Mcurrent | $161.2Mest. | $214.5Mest. | $139.3Mest. | $282.5Mest. |
| Revenue | $72.9M↑76% | $41.5M↑5397% | $755.0K↓96% | $19.2M↓37% | $30.3M |
| Operating Income | -$33.1M↑44% | -$59.6M↑39% | -$97.3M↓9% | -$89.7M↑13% | -$103.5M |
| Net Income | -$67.6M↓84% | -$36.8M↑64% | -$101.1M↑5% | -$106.1M↑7% | -$114.2M |
| EPS (Diluted) | $-0.67↓63% | $-0.41↑77% | $-1.77↑24% | $-2.33↑9% | $-2.55 |
| Gross Margin | 100.0% | 100.0%↑4094% | 2.4%↓97% | 90.8%↓3% | 93.9% |
| Operating Margin | -45.3%↑68% | -143.5%↑99% | -12887.7%↓2655% | -467.7%↓37% | -341.0% |
| ROE | -89.1%↓217% | -28.1%↑76% | -119.3%↓9% | -109.9%↓113% | -51.6% |
| Total Debt | $35.4M↓17% | $42.6M↓17% | $51.5M↓10% | $57.2M↓28% | $79.9M |
| Shareholders' Equity | $75.9M↓42% | $131.0M↑55% | $84.7M↓12% | $96.6M↓56% | $221.3M |
| Current Ratio | — | — | — | 2.90↓36% | 4.57 |
| Debt / Equity | 0.47↑43% | 0.33↓46% | 0.61↑2% | 0.59↑64% | 0.36 |
| Operating Cash Flow | -$39.4M↓271% | $23.0M↑193% | -$24.7M↑72% | -$87.4M↑16% | -$104.6M |
| Free Cash Flow | -$41.8M↓305% | $20.4M↑179% | -$25.8M↑71% | -$89.9M↑27% | -$123.1M |
Score history
Historical Score Timeline
Industry peers
Industry Peers
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CLLS vs Peers — Financial Grading
| Company | Market Cap | Price | Revenue | Net Income | ROE | D/E | Op. Margin | Curr. Ratio | Graham | Buffett | Lynch | Greenblatt | Piotroski | Dreman |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Merck & Co., Inc.MRK | $364.3B | $147.76 | $65.0B | $18.3B | 34.7% | 0.94 | — | 1.54 | 2/9 | 5/9 | 4/7 | 0/3 | F-Score 4 | 1/11 |
| ABBOTT LABORATORIESABT | $188.0B | $108.52 | $44.3B | $6.5B | 12.5% | 0.25 | 18.2% | 1.58 | 3/9 | 4/9 | 2/7 | 1/3 | F-Score 5 | 3/11 |
| BRISTOL MYERS SQUIBB COBMY | $129.7B | $63.43 | $48.2B | $7.1B | 38.2% | 2.44 | 19.4% | 1.26 | 2/9 | 1/9 | 3/7 | 1/3 | F-Score 8 | 5/11 |
| BIO-TECHNE CorpTECH | $11.4B | $72.80 | $1.2B | $73.4M | 3.8% | — | 8.4% | 3.46 | 4/9 | 3/9 | 3/7 | 0/3 | F-Score 5 | 4/11 |
| REPLIGEN CORPRGEN | $10.7B | $167.79 | $738.3M | $48.9M | 2.3% | 0.26 | 7.5% | 8.37 | 3/9 | 2/9 | 3/7 | 0/3 | F-Score 7 | 5/11 |
| IONIS PHARMACEUTICALS INCIONS | $4.8B | $29.06 | $943.7M | $381.4M | -78.0% | 3.60 | -40.4% | 3.83 | 3/9 | 1/9 | 1/7 | 0/3 | F-Score 4 | 3/11 |
| NEOGEN CORPNEOG | $2.5B | $11.23 | $870.4M | $7.9M | -0.4% | 0.76 | -2.5% | 3.82 | 3/9 | 1/9 | 2/7 | 0/3 | F-Score 6 | 4/11 |
| Pharvaris N.V.PHVS | $2.4B | $33.36 | — | $206.4M | -64.8% | 0.00 | — | — | 0/9 | 0/9 | 2/7 | 0/3 | F-Score 2 | 2/11 |