Cellectis S.A.

CLLS
About the company

Cellectis S.A., a clinical stage biotechnological company, develops products based on gene-editing with a portfolio of allogeneic chimeric antigen receptor T-cells product candidates in the field of immuno-oncology and gene therapy product candidates in other therapeutic indications.

Country: FrancePrice: $1.18Market Cap: $118.9M

Investment snapshot

6%positive consensus
Scored 1d ago

Positive

1

BUY / PASS

Neutral / negative

1 / 14

NEUTRAL / FAIL

Median fair value

—

No comparable estimates

Models with upside

0 / 17

Positive margin of safety

Key risk

No clean pass — all 16 investors flag at least one profitability criterion

Framework analysis

VerdictMeaning
BUYPositive purchase signal: the framework's buy requirements are met.
PASSThe company clears the framework's checklist or screen, but the framework does not produce a buy signal. For valuation frameworks this often means margin of safety is missing, insufficient, or unavailable; some screen-only frameworks have no intrinsic-value BUY state.
NEUTRALNeither a positive nor negative conclusion. It does not mean to hold an existing position.
FAILThe company does not clear the framework's requirements.
RankedRanked strategies do not use PASS: selected cohort is BUY, outside the cohort is FAIL, and unranked is NEUTRAL.

Current investor scores use trailing 12-month flows and the latest balance sheet where supported. Multi-year and EPS tests retain annual history; each framework shows its financial basis below. Intrinsic values use annual financials.

MetricGraham

Defensive Value

Buffett

Quality Compounder

Lynch

GARP

Greenblatt

Magic Formula

Piotroski

F-Score

Dreman

Contrarian Value

Munger

Quality Focus

Pabrai

Dhandho Framework

Akre

Three-Legged Stool

Marks

Risk-Aware Value

Ackman

Activist Value

Templeton

Global Bargain Hunter

Sleep

Scale Economies Shared

Asness

Systematic Factors

Neff

Low-P/E Total Return

Schloss

Asset-Value Discipline

O'Shaughnessy

Systematic Factor Composite

VerdictFAILFAILFAILNot rankedFAILFAILFAILFAILFAILFAILFAILPASSFAILFAILFAILFAILNEUTRAL
Score
AnalysisChecking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…
Intrinsic Value (annual)N/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/A
Margin of SafetyN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/A
Financial Basis

Annual history · FY 2025

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025 · Market data at 2026-11-01

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Qualitative assessment · Annual history · FY 2025

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Qualitative assessment · Annual history · FY 2025

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025 · Market data at 2026-11-01

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025 · Price history 2025-01-01–2026-11-01

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025 · Price history 2025-01-01–2026-11-01

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Annual history · FY 2025 · Price history 2025-01-01–2026-11-01

Latest source filing: 2026-03-20

Score computed: 2026-11-14

Where It Passes

    Where It Falls Short

    • Profitability0% pass✓ 2✗ 33▾

      No clean pass — all 16 investors flag at least one profitability criterion

      Positive EPS (10 years)0/12 years positive
      ✗GrahamPositive EPS every year for 10 years
      EPS Growth (3-yr avg, 10-yr window)
      ✗Graham>= 33% growth
      Net Income Positive (10+ years)0/12 years positive
      ✗BuffettPositive every year for 10+ years
      ROE (up to 5-year arithmetic mean)-79.6%
      ✗Buffett> 15% arithmetic mean (app rule)
      Operating Margin (10-yr trend)-45.3% (latest)
      ✗BuffettStable or rising over 10 years
      Free Cash Flow Proxy$-49.9M
      ✗BuffettPositive and growing
      Earnings Variance (10-yr CoV)
      ✗BuffettCoV < 0.3
      Retained Earnings Effectiveness
      ✗Buffett$1 retained -> > $1 market value created
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      3-5 Year EPS CAGR
      ✗Lynch15-30% (Fast Grower); > 0% to pass
      ROE-89.1%
      ✗Lynch> 15%
      EBIT / Enterprise Value-35.7%
      ✗Greenblatt> 10%
      Earnings Yield + ROC AssessmentEY=-35.7%, ROC=None
      ✗GreenblattBoth EY > 10% and ROC > 25%
      Net Income / Total Assets-20.82%
      ✗PiotroskiROA > 0
      ROA Change YoY-9.58% -> -20.82% (delta: -11.23%)
      ✗PiotroskiCurrent ROA > Prior ROA
      (CFO / Total Assets) vs ROACFO/Assets=-12.13%, ROA=-20.82%
      ✓PiotroskiCFO/Assets > ROA
      Gross Margin Change YoY100.0% -> 100.0%
      ✗PiotroskiImproved YoY
      Pre-Tax Income / Revenue-93.2%
      ✗Dreman>= 8%
      Net Income / Shareholders' Equity-89.1%
      ✗Dreman> 12%
      Margin of SafetyP/B=1.6x
      ✗PabraiP/B < 1.5 or P/E < 15
      Return on Equity-78.8% (3-yr avg)
      ✗AkreROE > 20% (3-year avg)
      Discount to Intrinsic Value
      ✗Marks>= 20% below intrinsic value
      Positive Net Income Frequency0/12 years positive
      ✗MarksPositive net income in >= 7 of last 10 years
      Operating Income / Revenue-45.3%
      ✗Ackman>= 15%
      Net Income / Shareholders Equity-89.1%
      ✗Ackman>= 15%
      5-Year EPS CAGR
      ✗Templeton> 0% (5-year EPS CAGR)
      Operating Margin Trend-12887.7% (2023) -> -45.3% (2025)
      ✓TempletonNon-negative operating-margin trend over 3 years
      Revenue growth vs. gross and operating margin trendgross margin 2.4% -> 100.0%, operating margin -12887.7% -> -45.3%
      ✗SleepRevenue rising; gross margin flat or falling; operating margin holding
      Net income / market capitalization-56.87%; #5120/6340 (top 80.8%)
      ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
      Gross profit / total assets+22.47%; #1893/3702 (top 51.1%)
      ✗AsnessTop 30% of eligible cross-section
      Net income / positive book equity-89.05%; #4531/5226 (top 86.7%)
      ✗AsnessTop 30% of eligible cross-section
      Negative 5-year standard deviation of ROA-0.1220; #3720/5884 (top 63.2%)
      ✗AsnessTop 30% of eligible cross-section
      3-5 Year Diluted EPS CAGR
      ✗Neff7%-20% annualized
      Positive Diluted-EPS Years0/10 years positive
      ✗Schloss>= 70% positive over 5-10 observed years (app rule)
    • Valuation0% pass✓ 2✗ 26▾

      No clean pass — all 13 investors flag at least one valuation criterion

      Price / 3-yr avg EPS
      ✗Graham<= 15x
      Price-to-Book Ratio1.6x
      ✗Graham<= 1.5x
      P/E x P/B
      ✗Graham<= 22.5
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      EBIT / Enterprise Value-35.7%
      ✗Greenblatt> 10%
      Earnings Yield + ROC AssessmentEY=-35.7%, ROC=None
      ✗GreenblattBoth EY > 10% and ROC > 25%
      Price / EPS
      ✗Dreman< 12x✗Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)
      Price / (CFO / Shares)N/A (negative CFPS)
      ✗Dreman< 8x
      Price / Book Value per Share1.6x
      ✗Dreman< 1.2x✗Templeton< 1.5x✗SchlossP/B <= 0.80x (app cutoff)
      Valuation ReasonablenessOE Yield=-42.1%
      ✗MungerP/E < 25 or Owner Earnings Yield > 5%
      P/E or FCF YieldFCF Yield=-35.1%
      ✗PabraiP/E < 15 or FCF Yield > 10%
      P/B or P/E vs. Historical AverageP/B=1.6x
      ✓MarksP/E < 15 or P/B < 2.0
      Discount to Intrinsic Value
      ✗Marks>= 20% below intrinsic value
      Price / FCF per ShareN/A (negative FCF)
      ✗Ackman<= 25
      Price vs. Trailing Low112% of trailing low ($1.05)
      ✓Templeton<= 120% of trailing low (certified split-adjusted live window)
      Net income / market capitalization-56.87%; #5120/6340 (top 80.8%)
      ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
      Positive book equity / market capitalization+0.6385; #2390/6449 (top 37.1%)
      ✗AsnessTop 30% of eligible cross-section
      Price / Diluted EPS
      ✗NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)
      (EPS CAGR % + Dividend Yield %) / P/E
      ✗Neff> 0.7 (Neff's published traditional edge)
      Price / Tangible Book Value per Share1.57x
      ✗SchlossP/TBV <= 1.00x (app cutoff)
      Book Value per Share Change
      ✗SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)
      Revenue / market capitalization+0.6137; #2356/5247 (top 44.9%)
      ✗OshaughnessyTop 10% of eligible cross-section
      (Operating cash flow - capex) / market capitalization-35.13%; #3727/4519 (top 82.5%)
      ✗OshaughnessyTop 10% of eligible cross-section
      Trailing six-month price return through the evaluation date-67.13%; #5594/6202 (top 90.2%)
      ✗OshaughnessyTop 10% of eligible cross-section
    • Cash Flow0% pass✓ 1✗ 11▾

      No clean pass — all 10 investors flag at least one cash flow criterion

      Free Cash Flow Proxy$-49.9M
      ✗BuffettPositive and growing
      FCF Positive and Growing$-41.8M
      ✗LynchPositive and growing
      Operating Cash Flow$-39.4M
      ✗PiotroskiCFO > 0
      (CFO / Total Assets) vs ROACFO/Assets=-12.13%, ROA=-20.82%
      ✓PiotroskiCFO/Assets > ROA
      Price / (CFO / Shares)N/A (negative CFPS)
      ✗Dreman< 8x
      P/E or FCF YieldFCF Yield=-35.1%
      ✗PabraiP/E < 15 or FCF Yield > 10%
      FCF Positive1/11 years FCF positive
      ✗MarksPositive FCF in majority of recent years
      (OCF - CapEx) / Market Cap-35.3%
      ✗Ackman>= 4%
      Price / FCF per ShareN/A (negative FCF)
      ✗Ackman<= 25
      Positive Operating Cash Flow frequency2/11 years positive
      ✗SleepPositive OCF in >= 70% of available years
      Operating Cash Flow - Capital Expenditures$-41.8M
      ✗Neff> $0 (app proxy for a strong fundamental case)
      (Operating cash flow - capex) / market capitalization-35.13%; #3727/4519 (top 82.5%)
      ✗OshaughnessyTop 10% of eligible cross-section
    • Growth0% pass✓ 3✗ 10▾

      No clean pass — all 8 investors flag at least one growth criterion

      EPS Growth (3-yr avg, 10-yr window)
      ✗Graham>= 33% growth
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      3-5 Year EPS CAGR
      ✗Lynch15-30% (Fast Grower); > 0% to pass
      Inventory Growth vs Revenue GrowthN/A (no inventory)
      ✓LynchInventory growth < Revenue growth
      EPS Growth Direction
      ✗DremanPositive over recent years
      EPS CAGR
      ✗Dreman> 5% annualized
      Positive Net Income Frequency0/12 years positive
      ✗MarksPositive net income in >= 7 of last 10 years
      3yr Median Revenue Growth75.8%
      ✓Ackman>= 5%
      Positive EPS Growth Frequency
      ✗AckmanPositive EPS growth in >= 3 of last 5 years
      5-Year EPS CAGR
      ✗Templeton> 0% (5-year EPS CAGR)
      Revenue growth vs. gross and operating margin trendgross margin 2.4% -> 100.0%, operating margin -12887.7% -> -45.3%
      ✗SleepRevenue rising; gross margin flat or falling; operating margin holding
      5-year Revenue CAGR7.4%
      ✓SleepCAGR > 7%
      3-5 Year Diluted EPS CAGR
      ✗Neff7%-20% annualized
    • Efficiency0% pass✓ 1✗ 10▾

      No clean pass — all 8 investors flag at least one efficiency criterion

      Current Ratio
      ✗Graham>= 2.0
      ROIC (3-5 yr avg)-83.0%
      ✗Buffett> 10%
      ROIC - WACC-93.0%
      ✗BuffettPositive (WACC = 10%)
      EBIT / (NWC + Net Fixed Assets)
      ✗Greenblatt> 25%
      Current Ratio Change YoY
      ✗PiotroskiIncreased YoY
      Revenue / Total Assets Change YoY0.11x -> 0.22x
      ✓PiotroskiImproved YoY
      Current Assets / Current Liabilities
      ✗Dreman> 1.5
      Return on Invested Capital-23.5%
      ✗Munger> 15%
      ROIC (high and growing)FY2023: ROIC=-56.5%; FY2024: ROIC=-27.1%; FY2025: ROIC=-23.5%
      ✗AkreLatest 3 consecutive FYs: ROIC > 15% in each
      Reinvestment Rate x ROICN/A (non-positive net income)
      ✗AkreReinvestment Rate * ROIC > 10%
      ROIC (5-year)0/5 years above 12% (latest -23.5%)
      ✗SleepROIC > 12% in a majority of years
    • Verdicts7% pass✓ 1✗ 14▾

      Split decision: 14 FAIL · 1 PASS · 1 NEUTRAL

      Overall verdict
      ✗GrahamFAIL (0/9)✗BuffettFAIL (0/9)✗LynchFAIL (1/7)•GreenblattNot ranked✗PiotroskiFAIL (F-Score 3)✗DremanFAIL (1/11)✗MungerFAIL (1/4)✗PabraiFAIL (0/3)✗AkreFAIL (1/6)✗MarksFAIL (1/5)✗AckmanFAIL (3/9)✓TempletonPASS (4/8)✗SleepFAIL (2/6)✗AsnessFAIL (Rank #2259/2370 (Top 95.3%))✗NeffFAIL (1/6)✗SchlossFAIL (1/7)•OshaughnessyNEUTRAL (Not ranked)
    • Debt & Leverage33% pass✓ 6✗ 9▾

      8 of 12 flag CLLS's debt & leverage — Graham, Buffett, Lynch +5 more

      Debt Levels0.47
      ✓MungerDebt/Equity < 0.5✗AkreDebt/Equity < 0.3
      LT Debt vs Net Current Assets
      ✗GrahamLT Debt <= Net Current Assets
      Debt/Equity & Interest CoverageD/E: 0.47, IC: -0.6x
      ✗BuffettD/E < 0.5 AND Interest Coverage > 5x
      Total Debt / Equity0.47
      ✗Lynch< 0.33
      Cash - Long-term Debt
      ✗LynchPositive preferred
      LT Debt / Total Assets Change0.00% -> 0.00%
      ✓PiotroskiDecreased YoY
      Current Assets / Current Liabilities
      ✗Dreman> 1.5✗SchlossCurrent ratio >= 1.50x (app cutoff)
      Total Debt / Shareholders' Equity0.47
      ✓Dreman< 0.8✓Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✓SchlossD/E < 1.00x
      Interest Coverage & Debt/EBITDAIC=-0.6x, D/EBITDA=N/A
      ✗MarksInterest Coverage > 3x; Debt/EBITDA < 4x
      Total Debt / Shareholders Equity0.47
      ✓Ackman<= 1.0
      Negative debt-to-equity (higher means less debt)-0.4667; #2402/4210 (top 57.1%)
      ✗AsnessTop 30% of eligible cross-section

    Business & financials

    Financial snapshot: annual FY 2025. Current investor scores may use newer quarterly data.

    Company Profile

    Industry: Pharmaceutical Products
    SIC Sector: Chemicals & Pharmaceuticals
    Size: Micro Cap($118.9M)
    Revenue: $72.9M+75.8% YoY
    Net Income: $67.6M-83.9% YoY

    Financial Snapshot

    Operating Margin-45.3%
    Return on Equity-89.1%
    Debt / Equity0.47
    Current Ratio--
    EPS (Diluted)$-0.67
    Shares Retired−0.2% / −39.8% 2y

    Shareholder Return

    Fiscal 2025

    Issued 0.2% of shares last year, 39.8% issued over two.

    Buybacks
    —
    Dividends
    —

    Company Financials

    Latest TTM and quarters alongside annual years

    TTM sums four consecutive quarters and uses the latest quarter-end balances. Quarter columns show three-month results; annual columns show full-year totals. Growth compares the same period a year earlier. EPS is not added for TTM; full-year ratios are blank for quarters.

    MetricFY 2025
    Sources
    • 20-F · 2026-03-20
    FY 2024
    Sources
    • 20-F · 2025-03-14
    FY 2023
    Sources
    • 20-F · 2025-03-14
    FY 2022
    Sources
    • 20-F · 2023-03-14
    FY 2021
    Sources
    • 20-F · 2022-03-03
    Market Cap$118.9Mcurrent$161.2Mest.$214.5Mest.$139.3Mest.$282.5Mest.
    Revenue$72.9M↑76%$41.5M↑5397%$755.0K↓96%$19.2M↓37%$30.3M
    Operating Income-$33.1M↑44%-$59.6M↑39%-$97.3M↓9%-$89.7M↑13%-$103.5M
    Net Income-$67.6M↓84%-$36.8M↑64%-$101.1M↑5%-$106.1M↑7%-$114.2M
    EPS (Diluted)$-0.67↓63%$-0.41↑77%$-1.77↑24%$-2.33↑9%$-2.55
    Gross Margin100.0%100.0%↑4094%2.4%↓97%90.8%↓3%93.9%
    Operating Margin-45.3%↑68%-143.5%↑99%-12887.7%↓2655%-467.7%↓37%-341.0%
    ROE-89.1%↓217%-28.1%↑76%-119.3%↓9%-109.9%↓113%-51.6%
    Total Debt$35.4M↓17%$42.6M↓17%$51.5M↓10%$57.2M↓28%$79.9M
    Shareholders' Equity$75.9M↓42%$131.0M↑55%$84.7M↓12%$96.6M↓56%$221.3M
    Current Ratio———2.90↓36%4.57
    Debt / Equity0.47↑43%0.33↓46%0.61↑2%0.59↑64%0.36
    Operating Cash Flow-$39.4M↓271%$23.0M↑193%-$24.7M↑72%-$87.4M↑16%-$104.6M
    Free Cash Flow-$41.8M↓305%$20.4M↑179%-$25.8M↑71%-$89.9M↑27%-$123.1M

    Score history

    Historical Score Timeline

    Industry peers

    Industry Peers

    Similar companies in Pharmaceutical Products

    CLLS vs Peers — Financial Grading

    Revenue$72.9MBottom 25%
    Net Income$67.6MBottom 25%
    ROE-89.1%Bottom 25%
    D/E0.47Median
    Op. Margin-45.3%Bottom 25%
    Curr. Ratio—
    CompanyMarket CapPriceRevenueNet IncomeROED/EOp. MarginCurr. RatioGrahamBuffettLynchGreenblattPiotroskiDreman
    Merck & Co., Inc.MRK$364.3B$147.76$65.0B$18.3B34.7%0.94—1.542/95/94/70/3F-Score 41/11
    ABBOTT LABORATORIESABT$188.0B$108.52$44.3B$6.5B12.5%0.2518.2%1.583/94/92/71/3F-Score 53/11
    BRISTOL MYERS SQUIBB COBMY$129.7B$63.43$48.2B$7.1B38.2%2.4419.4%1.262/91/93/71/3F-Score 85/11
    BIO-TECHNE CorpTECH$11.4B$72.80$1.2B$73.4M3.8%—8.4%3.464/93/93/70/3F-Score 54/11
    REPLIGEN CORPRGEN$10.7B$167.79$738.3M$48.9M2.3%0.267.5%8.373/92/93/70/3F-Score 75/11
    IONIS PHARMACEUTICALS INCIONS$4.8B$29.06$943.7M$381.4M-78.0%3.60-40.4%3.833/91/91/70/3F-Score 43/11
    NEOGEN CORPNEOG$2.5B$11.23$870.4M$7.9M-0.4%0.76-2.5%3.823/91/92/70/3F-Score 64/11
    Pharvaris N.V.PHVS$2.4B$33.36—$206.4M-64.8%0.00——0/90/92/70/3F-Score 22/11