enGene Therapeutics Inc.

ENGN
About the company

enGene Therapeutics Inc., through its subsidiary enGene, Inc., operates as a clinical-stage biotechnology company in Canada. The company develops genetic medicines to help patients suffering from bladder cancer. Its lead product candidate is detalimogene voraplasmid, a monotherapy for the treatment of non-muscle invasive bladder cancer (NMIBC). Its pipeline includes LEGEND, which is in Phase 2.

Country: CanadaPrice: $2.41Market Cap: $161.5M

Investment snapshot

0%positive consensus
Scored 1d ago

Positive

0

BUY / PASS

Neutral / negative

4 / 12

NEUTRAL / FAIL

Median fair value

$431.44

+17802.1% vs price

Models with upside

4 / 17

Positive margin of safety

Strongest signal

ENGN undervalued: all 4 models price fair value above $2.41 (median $431.44)

Key risk

No clean pass — all 8 investors flag at least one growth criterion

Framework analysis

VerdictMeaning
BUYPositive purchase signal: the framework's buy requirements are met.
PASSThe company clears the framework's checklist or screen, but the framework does not produce a buy signal. For valuation frameworks this often means margin of safety is missing, insufficient, or unavailable; some screen-only frameworks have no intrinsic-value BUY state.
NEUTRALNeither a positive nor negative conclusion. It does not mean to hold an existing position.
FAILThe company does not clear the framework's requirements.
RankedRanked strategies do not use PASS: selected cohort is BUY, outside the cohort is FAIL, and unranked is NEUTRAL.

Current investor scores use trailing 12-month flows and the latest balance sheet where supported. Multi-year and EPS tests retain annual history; each framework shows its financial basis below. Intrinsic values use annual financials.

MetricGraham

Defensive Value

Buffett

Quality Compounder

Lynch

GARP

Greenblatt

Magic Formula

Piotroski

F-Score

Dreman

Contrarian Value

Munger

Quality Focus

Pabrai

Dhandho Framework

Akre

Three-Legged Stool

Marks

Risk-Aware Value

Ackman

Activist Value

Templeton

Global Bargain Hunter

Sleep

Scale Economies Shared

Asness

Systematic Factors

Neff

Low-P/E Total Return

Schloss

Asset-Value Discipline

O'Shaughnessy

Systematic Factor Composite

VerdictFAILFAILFAILFAIL · Rank #2832 (Top 91.4%)FAILFAILNEUTRALNEUTRALFAILFAILFAILFAILFAILNEUTRALFAILFAILNEUTRAL
Score
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Intrinsic Value (annual)N/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/A
Margin of Safety+81.3%N/AN/AN/AN/A+99.7%N/AN/AN/A+99.7%N/A+97.9%N/AN/AN/AN/AN/A
Financial Basis

Annual history · FY 2025 · Balance sheet at 2026-07-31

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-07-31

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Annual history · FY 2025 · Balance sheet at 2026-07-31 · TTM ended 2026-07-31 vs 2025-07-31 · TTM ended 2026-07-31

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2025-12-22

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2025-12-22

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-07-31 · Balance sheet at 2026-07-31 · Market data at 2026-11-01

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Qualitative assessment · Annual history · FY 2025 · TTM ended 2026-07-31 · Balance sheet at 2026-07-31

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Qualitative assessment · Annual history · FY 2025

Latest source filing: 2025-12-22

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment · Balance sheet at 2026-07-31

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-07-31 · Qualitative assessment

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-07-31 · Balance sheet at 2026-07-31 · Market data at 2026-11-01

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 · Balance sheet at 2026-07-31

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment

Latest source filing: 2025-12-22

Score computed: 2026-11-14

TTM ended 2026-07-31 · Balance sheet at 2026-07-31 · Price history 2025-01-01–2026-11-01 · Annual history · FY 2025

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-07-31

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Annual history · FY 2025 · Balance sheet at 2026-07-31

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-07-31 · Price history 2025-01-01–2026-11-01

Latest source filing: 2026-09-08

Score computed: 2026-11-14

Where It Passes

  • Valuation models100% pass✓ 4▾

    ENGN undervalued: all 4 models price fair value above $2.41 (median $431.44)

    Graham fair value$12.89
    ✓Graham+81.3% margin vs $2.41
    Dreman fair value$774.85
    ✓Dreman+99.7% margin vs $2.41
    Marks fair value$747.26
    ✓Marks+99.7% margin vs $2.41
    Templeton fair value$115.62
    ✓Templeton+97.9% margin vs $2.41
  • Debt & Leverage58% pass✓ 10✗ 5▾

    7 of 12 pass — Graham, Buffett, Lynch +2 more object

    LT Debt vs Net Current Assets
    ✗GrahamLT Debt <= Net Current Assets
    Debt/Equity & Interest CoverageD/E: 0.11, IC: -44.5x
    ✗BuffettD/E < 0.5 AND Interest Coverage > 5x
    Total Debt / Equity0.11
    ✓Lynch< 0.33
    Cash - Long-term Debt
    ✗LynchPositive preferred
    LT Debt / Total Assets Change0.00% -> 0.00%
    ✓PiotroskiDecreased YoY
    Current Assets / Current Liabilities10.21
    ✓Dreman> 1.5✓SchlossCurrent ratio >= 1.50x (app cutoff)
    Total Debt / Shareholders' Equity0.11
    ✓Dreman< 0.8✓Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✓SchlossD/E < 1.00x
    Debt Levels0.11
    ✓MungerDebt/Equity < 0.5✓AkreDebt/Equity < 0.3
    Interest Coverage & Debt/EBITDAIC=-44.5x, D/EBITDA=N/A
    ✗MarksInterest Coverage > 3x; Debt/EBITDA < 4x
    Total Debt / Shareholders Equity0.11
    ✓Ackman<= 1.0
    Negative debt-to-equity (higher means less debt)-0.1101; #1326/4210 (top 31.5%)
    ✗AsnessTop 30% of eligible cross-section

Where It Falls Short

  • Growth0% pass✓ 1✗ 12▾

    No clean pass — all 8 investors flag at least one growth criterion

    EPS Growth (3-yr avg, 10-yr window)
    ✗Graham>= 33% growth
    Basic earnings-growth PEG (dividends excluded)P/E 1.1x (growth N/A)
    ✗Lynch< 1.0 (ideally < 0.5)
    3-5 Year EPS CAGR-62.7%
    ✗Lynch15-30% (Fast Grower); > 0% to pass
    Inventory Growth vs Revenue GrowthN/A (no inventory)
    ✓LynchInventory growth < Revenue growth
    EPS Growth Direction$44.30 (2022) -> $2.29 (2025)
    ✗DremanPositive over recent years
    EPS CAGR-62.7% CAGR over 3 years
    ✗Dreman> 5% annualized
    Positive Net Income Frequency0/4 years positive
    ✗MarksPositive net income in >= 7 of last 10 years
    3yr Median Revenue Growth
    ✗Ackman>= 5%
    Positive EPS Growth Frequency2/3 years with positive EPS growth
    ✗AckmanPositive EPS growth in >= 3 of last 5 years
    5-Year EPS CAGR-62.7% CAGR over 3 years
    ✗Templeton> 0% (5-year EPS CAGR)
    Revenue growth vs. gross and operating margin trend
    ✗SleepRevenue rising; gross margin flat or falling; operating margin holding
    5-year Revenue CAGR
    ✗SleepCAGR > 7%
    3-5 Year Diluted EPS CAGR-62.7% over 3 years
    ✗Neff7%-20% annualized
  • Verdicts0% pass✗ 13▾

    Split decision: 12 FAIL · 4 NEUTRAL

    Overall verdict
    ✗GrahamFAIL (2/9)✗BuffettFAIL (0/9)✗LynchFAIL (2/7)✗GreenblattRank #2832✗PiotroskiFAIL (F-Score 2)✗DremanFAIL (3/11)•MungerNEUTRAL (3/4)•PabraiNEUTRAL (2/3)✗AkreFAIL (1/6)✗MarksFAIL (2/5)✗AckmanFAIL (1/9)✗TempletonFAIL (3/8)✗SleepFAIL (0/6)•AsnessNEUTRAL (Not ranked)✗NeffFAIL (1/6)✗SchlossFAIL (2/7)•OshaughnessyNEUTRAL (Not ranked)
  • Profitability6% pass✓ 3✗ 32▾

    15 of 16 flag ENGN's profitability — Graham, Buffett, Lynch +12 more

    Positive EPS (10 years)4/5 years positive
    ✗GrahamPositive EPS every year for 10 years
    EPS Growth (3-yr avg, 10-yr window)
    ✗Graham>= 33% growth
    Net Income Positive (10+ years)0/5 years positive
    ✗BuffettPositive every year for 10+ years
    ROE (up to 5-year arithmetic mean)-76.0%
    ✗Buffett> 15% arithmetic mean (app rule)
    Operating Margin (10-yr trend)
    ✗BuffettStable or rising over 10 years
    Free Cash Flow Proxy$-117.3M
    ✗BuffettPositive and growing
    Earnings Variance (10-yr CoV)
    ✗BuffettCoV < 0.3
    Retained Earnings Effectiveness
    ✗Buffett$1 retained -> > $1 market value created
    Basic earnings-growth PEG (dividends excluded)P/E 1.1x (growth N/A)
    ✗Lynch< 1.0 (ideally < 0.5)
    3-5 Year EPS CAGR-62.7%
    ✗Lynch15-30% (Fast Grower); > 0% to pass
    ROE-56.6%
    ✗Lynch> 15%
    EBIT / Enterprise Value-91.4%
    ✗Greenblatt> 10%
    Earnings Yield + ROC AssessmentEY=-91.4%, ROC=-101.2%
    ✗GreenblattBoth EY > 10% and ROC > 25%
    Net Income / Total Assets-52.97%
    ✗PiotroskiROA > 0
    ROA Change YoY-17.72% -> -52.97% (delta: -35.24%)
    ✗PiotroskiCurrent ROA > Prior ROA
    (CFO / Total Assets) vs ROACFO/Assets=-44.81%, ROA=-52.97%
    ✓PiotroskiCFO/Assets > ROA
    Gross Margin Change YoY
    ✗PiotroskiImproved YoY
    Pre-Tax Income / Revenue
    ✗Dreman>= 8%
    Net Income / Shareholders' Equity-56.6%
    ✗Dreman> 12%
    Margin of SafetyP/E=1.1x
    ✓PabraiP/B < 1.5 or P/E < 15
    Return on Equity-76.0% (3-yr avg)
    ✗AkreROE > 20% (3-year avg)
    Discount to Intrinsic Value99.7% (IV=$774.85 vs Price=$2.41)
    ✓Marks>= 20% below intrinsic value
    Positive Net Income Frequency0/4 years positive
    ✗MarksPositive net income in >= 7 of last 10 years
    Operating Income / Revenue
    ✗Ackman>= 15%
    Net Income / Shareholders Equity-56.6%
    ✗Ackman>= 15%
    5-Year EPS CAGR-62.7% CAGR over 3 years
    ✗Templeton> 0% (5-year EPS CAGR)
    Operating Margin Trend
    ✗TempletonNon-negative operating-margin trend over 3 years
    Revenue growth vs. gross and operating margin trend
    ✗SleepRevenue rising; gross margin flat or falling; operating margin holding
    Net income / market capitalization-80.71%; #5283/6340 (top 83.3%)
    ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
    Gross profit / total assets
    ✗AsnessTop 30% of eligible cross-section
    Net income / positive book equity-56.61%; #4289/5226 (top 82.1%)
    ✗AsnessTop 30% of eligible cross-section
    Negative 5-year standard deviation of ROA-0.3895; #4783/5884 (top 81.3%)
    ✗AsnessTop 30% of eligible cross-section
    3-5 Year Diluted EPS CAGR-62.7% over 3 years
    ✗Neff7%-20% annualized
    Positive Diluted-EPS Years
    ✗Schloss>= 70% positive over 5-10 observed years (app rule)
  • Cash Flow10% pass✓ 2✗ 10▾

    9 of 10 flag ENGN's cash flow — Buffett, Lynch, Piotroski +6 more

    Free Cash Flow Proxy$-117.3M
    ✗BuffettPositive and growing
    FCF Positive and Growing$-104.0M
    ✗LynchPositive and growing
    Operating Cash Flow$-99.2M
    ✗PiotroskiCFO > 0
    (CFO / Total Assets) vs ROACFO/Assets=-44.81%, ROA=-52.97%
    ✓PiotroskiCFO/Assets > ROA
    Price / (CFO / Shares)
    ✗Dreman< 8x
    P/E or FCF YieldP/E=1.1x, FCF Yield=-62.4%
    ✓PabraiP/E < 15 or FCF Yield > 10%
    FCF Positive0/4 years FCF positive
    ✗MarksPositive FCF in majority of recent years
    (OCF - CapEx) / Market Cap
    ✗Ackman>= 4%
    Price / FCF per Share
    ✗Ackman<= 25
    Positive Operating Cash Flow frequency0/4 years positive
    ✗SleepPositive OCF in >= 70% of available years
    Operating Cash Flow - Capital Expenditures$-104.0M
    ✗Neff> $0 (app proxy for a strong fundamental case)
    (Operating cash flow - capex) / market capitalization-64.39%; #3934/4519 (top 87.1%)
    ✗OshaughnessyTop 10% of eligible cross-section
  • Valuation23% pass✓ 9✗ 19▾

    10 of 13 flag ENGN's valuation — Graham, Lynch, Greenblatt +7 more

    Price / 3-yr avg EPS0.0x
    ✓Graham<= 15x
    Price-to-Book Ratio
    ✗Graham<= 1.5x
    P/E x P/B
    ✗Graham<= 22.5
    Basic earnings-growth PEG (dividends excluded)P/E 1.1x (growth N/A)
    ✗Lynch< 1.0 (ideally < 0.5)
    EBIT / Enterprise Value-91.4%
    ✗Greenblatt> 10%
    Earnings Yield + ROC AssessmentEY=-91.4%, ROC=-101.2%
    ✗GreenblattBoth EY > 10% and ROC > 25%
    Price / EPS1.1x
    ✓Dreman< 12x✓Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)
    Price / (CFO / Shares)
    ✗Dreman< 8x
    Price / Book Value per Share
    ✗Dreman< 1.2x✗Templeton< 1.5x✗SchlossP/B <= 0.80x (app cutoff)
    Valuation ReasonablenessP/E=1.1x
    ✓MungerP/E < 25 or Owner Earnings Yield > 5%
    P/E or FCF YieldP/E=1.1x, FCF Yield=-62.4%
    ✓PabraiP/E < 15 or FCF Yield > 10%
    P/B or P/E vs. Historical AverageP/E=1.1x
    ✓MarksP/E < 15 or P/B < 2.0
    Discount to Intrinsic Value99.7% (IV=$774.85 vs Price=$2.41)
    ✓Marks>= 20% below intrinsic value
    Price / FCF per Share
    ✗Ackman<= 25
    Price vs. Trailing Low158% of trailing low ($1.53)
    ✗Templeton<= 120% of trailing low (certified split-adjusted live window)
    Net income / market capitalization-80.71%; #5283/6340 (top 83.3%)
    ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
    Positive book equity / market capitalization+1.4259; #978/6449 (top 15.2%)
    ✓AsnessTop 30% of eligible cross-section
    Price / Diluted EPS1.1x
    ✓NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)
    (EPS CAGR % + Dividend Yield %) / P/E
    ✗Neff> 0.7 (Neff's published traditional edge)
    Price / Tangible Book Value per Share
    ✗SchlossP/TBV <= 1.00x (app cutoff)
    Book Value per Share Change
    ✗SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)
    Revenue / market capitalization
    ✗OshaughnessyTop 10% of eligible cross-section
    (Operating cash flow - capex) / market capitalization-64.39%; #3934/4519 (top 87.1%)
    ✗OshaughnessyTop 10% of eligible cross-section
    Trailing six-month price return through the evaluation date+30.27%; #1012/6202 (top 16.3%)
    ✗OshaughnessyTop 10% of eligible cross-section
  • Efficiency25% pass✓ 2✗ 9▾

    6 of 8 flag ENGN's efficiency — Buffett, Greenblatt, Piotroski +3 more

    Current Ratio10.21
    ✓Graham>= 2.0
    ROIC (3-5 yr avg)-59.1%
    ✗Buffett> 10%
    ROIC - WACC-69.1%
    ✗BuffettPositive (WACC = 10%)
    EBIT / (NWC + Net Fixed Assets)-101.2%
    ✗Greenblatt> 25%
    Current Ratio Change YoY16.87 -> 6.30
    ✗PiotroskiIncreased YoY
    Revenue / Total Assets Change YoY
    ✗PiotroskiImproved YoY
    Current Assets / Current Liabilities10.21
    ✓Dreman> 1.5
    Return on Invested Capital-42.2%
    ✗Munger> 15%
    ROIC (high and growing)FY2023: ROIC=-28.2%; FY2024: ROIC=-18.0%; FY2025: ROIC=-50.9%
    ✗AkreLatest 3 consecutive FYs: ROIC > 15% in each
    Reinvestment Rate x ROICN/A (non-positive net income)
    ✗AkreReinvestment Rate * ROIC > 10%
    ROIC (5-year)0/3 years above 12% (latest -50.9%)
    ✗SleepROIC > 12% in a majority of years

Business & financials

Financial snapshot: annual FY 2025. Current investor scores may use newer quarterly data.

Company Profile

Industry: Pharmaceutical Products
SIC Sector: Chemicals & Pharmaceuticals
Size: Micro Cap($161.5M)
Revenue: N/A
Net Income: $117.3M-112.7% YoY

Financial Snapshot

Operating Margin--
Return on Equity-69.9%
Debt / Equity0.14
Current Ratio6.30
EPS (Diluted)$2.29

Company Financials

Latest TTM and quarters alongside annual years

TTM sums four consecutive quarters and uses the latest quarter-end balances. Quarter columns show three-month results; annual columns show full-year totals. Growth compares the same period a year earlier. EPS is not added for TTM; full-year ratios are blank for quarters.

The latest annual period end is unavailable. Showing the latest fiscal cycle’s quarters; quarter and annual columns may overlap. Quarterly shows the full quarter history.

MetricTTM · 2026-07-31

2025-08-01 – 2026-07-31

Sources · derived quarter values

Derived from cumulative filings: net income, operating income, ebit, pre tax income, interest expense, operating cash flow, depreciation amortization, capex.

Q3 FY 2026

2026-05-01 – 2026-07-31

Sources · derived quarter values

Derived from cumulative filings: operating cash flow, capex.

Q2 FY 2026

2026-02-01 – 2026-04-30

Sources · derived quarter values

Derived from cumulative filings: operating cash flow, capex.

Q1 FY 2026

2025-11-01 – 2026-01-31

Sources
FY 2025
Sources
  • 10-K · 2025-12-22
FY 2024
Sources
  • 10-K · 2024-12-19
FY 2023
Sources
  • 10-K · 2024-12-19
FY 2022
Sources
  • 10-K · 2024-01-29
FY 2021
Sources
  • 10-K · 2024-01-29
Market Cap$161.5Mcurrent----------------
Revenue------------------
Operating Income-$136.6M↓35%-$34.0M↓14%-$32.0M↓18%-$31.2M↓17%-$123.2M↓98%-$62.3M↓139%-$26.1M↓34%-$19.4M--
Net Income-$130.4M↓38%-$32.5M↓12%-$30.2M↓17%-$29.8M↓21%-$117.3M↓113%-$55.1M↑45%-$99.9M↓308%-$24.5M--
EPS (Diluted)--$-0.47↓182%$-0.43↓184%$0.44↓8%$2.29↑57%$1.46↓99%$151.22↑241%$44.30--
Gross Margin—————————
Operating Margin—————————
ROE-56.6%↓20%———-69.9%↓246%-20.2%↑85%-137.8%↓532%31.9%—
Total Debt$25.4M↑10%$25.4M↑10%$25.1M↑6%$24.9M↑7%$23.3M↑3237%$699.0K↑24%$562.0K↓97%$18.7M--
Shareholders' Equity$230.3M↑15%$230.3M↑15%$255.2M↑12%$281.5M↑13%$167.7M↓38%$272.6M↑276%$72.5M↑195%-$76.6M↓43%-$53.4M
Current Ratio10.21↓1%10.21↓1%12.57↓1%11.75↓32%6.30↓63%16.87↑4%16.25↑267%4.42—
Debt / Equity0.11↓4%0.11↓4%0.10↓5%0.09↓5%0.14↑5324%0.00↓67%0.01↑103%-0.24—
Operating Cash Flow-$103.3M↓10%-$18.9M↑26%-$30.5M↓33%-$28.9M↓12%-$99.2M↓106%-$48.3M↓95%-$24.7M↓41%-$17.6M--
Free Cash Flow-$104.0M↓9%-$18.9M↑28%-$30.6M↓33%-$29.1M↓12%-$100.7M↓105%-$49.2M↓96%-$25.1M↓41%-$17.7M--

Score history

Historical Score Timeline

Industry peers

Industry Peers

Similar companies in Pharmaceutical Products

ENGN vs Peers — Financial Grading

RevenueN/A
Net Income$117.3MBottom 25%
ROE-69.9%Bottom 25%
D/E0.14Top 25%
Op. Margin—
Curr. Ratio6.30Top 25%
CompanyMarket CapPriceRevenueNet IncomeROED/EOp. MarginCurr. RatioGrahamBuffettLynchGreenblattPiotroskiDreman
Merck & Co., Inc.MRK$364.3B$147.76$65.0B$18.3B34.7%0.94—1.542/95/94/70/3F-Score 41/11
ABBOTT LABORATORIESABT$188.0B$108.52$44.3B$6.5B12.5%0.2518.2%1.583/94/92/71/3F-Score 53/11
BRISTOL MYERS SQUIBB COBMY$129.7B$63.43$48.2B$7.1B38.2%2.4419.4%1.262/91/93/71/3F-Score 85/11
BIO-TECHNE CorpTECH$11.4B$72.80$1.2B$73.4M3.8%—8.4%3.464/93/93/70/3F-Score 54/11
REPLIGEN CORPRGEN$10.7B$167.79$738.3M$48.9M2.3%0.267.5%8.373/92/93/70/3F-Score 75/11
IONIS PHARMACEUTICALS INCIONS$4.8B$29.06$943.7M$381.4M-78.0%3.60-40.4%3.833/91/91/70/3F-Score 43/11
NEOGEN CORPNEOG$2.5B$11.23$870.4M$7.9M-0.4%0.76-2.5%3.823/91/92/70/3F-Score 64/11
Pharvaris N.V.PHVS$2.4B$33.36—$206.4M-64.8%0.00——0/90/92/70/3F-Score 22/11