Esperion Therapeutics, Inc.
ESPRAbout the company
Esperion Therapeutics, Inc., a biopharmaceutical company, develops and commercializes medicines for the treatment of patients with elevated low density lipoprotein cholesterol (LDL-C) in the United States. The company's marketed products include NEXLETOL (bempedoic acid) and NEXLIZET (bempedoic acid and ezetimibe) tablets that are oral, once-daily, non-statin medicines for the treatment of primary hyperlipidemia in adults with heterozygous familial hypercholesterolemia cardiovascular disease who require additional lowering of LDL-C.
Investment snapshot
Positive
3
BUY / PASS
Neutral / negative
2 / 11
NEUTRAL / FAIL
Median fair value
—
No comparable estimates
Models with upside
0 / 17
Positive margin of safety
Key risk
All 13 investors flag ESPR's valuation
Framework analysis
| Verdict | Meaning |
|---|---|
| BUY | Positive purchase signal: the framework's buy requirements are met. |
| PASS | The company clears the framework's checklist or screen, but the framework does not produce a buy signal. For valuation frameworks this often means margin of safety is missing, insufficient, or unavailable; some screen-only frameworks have no intrinsic-value BUY state. |
| NEUTRAL | Neither a positive nor negative conclusion. It does not mean to hold an existing position. |
| FAIL | The company does not clear the framework's requirements. |
| Ranked | Ranked strategies do not use PASS: selected cohort is BUY, outside the cohort is FAIL, and unranked is NEUTRAL. |
Current investor scores use trailing 12-month flows and the latest balance sheet where supported. Multi-year and EPS tests retain annual history; each framework shows its financial basis below. Intrinsic values use annual financials.
| Metric | Graham Defensive Value | Buffett Quality Compounder | Lynch GARP | Greenblatt Magic Formula | Piotroski F-Score | Dreman Contrarian Value | Munger Quality Focus | Pabrai Dhandho Framework | Akre Three-Legged Stool | Marks Risk-Aware Value | Ackman Activist Value | Templeton Global Bargain Hunter | Sleep Scale Economies Shared | Asness Systematic Factors | Neff Low-P/E Total Return | Schloss Asset-Value Discipline | O'Shaughnessy Systematic Factor Composite |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Verdict | FAIL | FAIL | FAIL | Not ranked | PASS | FAIL | FAIL | FAIL | FAIL | FAIL | PASS | FAIL | PASS | NEUTRAL | FAIL | FAIL | NEUTRAL |
| Score | |||||||||||||||||
| Analysis | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… |
| Intrinsic Value (annual) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Margin of Safety | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Financial Basis | TTM ended 2026-03-31 · Balance sheet at 2026-03-31 · Annual history · FY 2025 Latest source filing: 2026-05-08 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-10 Score computed: 2026-11-14 | Annual history · FY 2025 · TTM ended 2026-03-31 vs 2025-03-31 · TTM ended 2026-03-31 Latest source filing: 2026-05-08 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-10 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-10 Score computed: 2026-11-14 | Annual history · FY 2025 · TTM ended 2026-03-31 · Balance sheet at 2026-03-31 · Market data at 2026-09-01 Latest source filing: 2026-05-08 Score computed: 2026-11-14 | Qualitative assessment · Annual history · FY 2025 Latest source filing: 2026-03-10 Score computed: 2026-11-14 | Qualitative assessment · Annual history · FY 2025 Latest source filing: 2026-03-10 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment · TTM ended 2026-03-31 Latest source filing: 2026-05-08 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-10 Score computed: 2026-11-14 | Annual history · FY 2025 · TTM ended 2026-03-31 · Market data at 2026-09-01 Latest source filing: 2026-05-08 Score computed: 2026-11-14 | Annual history · FY 2025 · Price history 2025-01-01–2026-09-01 Latest source filing: 2026-03-10 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-10 Score computed: 2026-11-14 | TTM ended 2026-03-31 · Balance sheet at 2026-03-31 · Price history 2025-01-01–2026-09-01 · Annual history · FY 2025 Latest source filing: 2026-05-08 Score computed: 2026-11-14 | Annual history · FY 2025 · TTM ended 2026-03-31 Latest source filing: 2026-05-08 Score computed: 2026-11-14 | Annual history · FY 2025 · Balance sheet at 2026-03-31 Latest source filing: 2026-05-08 Score computed: 2026-11-14 | TTM ended 2026-03-31 · Annual history · FY 2025 · Price history 2025-01-01–2026-09-01 Latest source filing: 2026-05-08 Score computed: 2026-11-14 |
Where It Passes
Where It Falls Short
- Valuation0% pass✗ 28▾
All 13 investors flag ESPR's valuation
Price / 3-yr avg EPS✗Graham<= 15xPrice-to-Book Ratio✗Graham<= 1.5xP/E x P/B✗Graham<= 22.5Basic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)EBIT / Enterprise Value9.2%✗Greenblatt> 10%Earnings Yield + ROC AssessmentEY=9.2%, ROC=N/A (invested capital <= 0)✗GreenblattBoth EY > 10% and ROC > 25%Price / EPS✗Dreman< 12x✗Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)Price / (CFO / Shares)N/A (negative CFPS)✗Dreman< 8xPrice / Book Value per ShareN/A (negative BVPS)✗Dreman< 1.2x✗Templeton< 1.5x✗SchlossP/B <= 0.80x (app cutoff)Valuation Reasonableness✗MungerP/E < 25 or Owner Earnings Yield > 5%P/E or FCF YieldFCF Yield=-1.6%✗PabraiP/E < 15 or FCF Yield > 10%P/B or P/E vs. Historical Average✗MarksP/E < 15 or P/B < 2.0Discount to Intrinsic ValueN/A (negative normalized EPS)✗Marks>= 20% below intrinsic valuePrice / FCF per ShareN/A (negative FCF)✗Ackman<= 25Price vs. Trailing Low✗Templeton<= 120% of trailing low (certified split-adjusted live window)Net income / market capitalization-0.91%; #3393/6340 (top 53.5%)✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-sectionPositive book equity / market capitalization-0.3758; #5913/6449 (top 91.7%)✗AsnessTop 30% of eligible cross-sectionPrice / Diluted EPS✗NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)(EPS CAGR % + Dividend Yield %) / P/E✗Neff> 0.7 (Neff's published traditional edge)Price / Tangible Book Value per ShareN/A (non-positive TBVPS)✗SchlossP/TBV <= 1.00x (app cutoff)Book Value per Share Change✗SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)Revenue / market capitalization+0.5104; #2603/5247 (top 49.6%)✗OshaughnessyTop 10% of eligible cross-section(Operating cash flow - capex) / market capitalization-2.24%; #2776/4519 (top 61.4%)✗OshaughnessyTop 10% of eligible cross-sectionTrailing six-month price return through the evaluation date✗OshaughnessyTop 10% of eligible cross-section - Cash Flow0% pass✓ 1✗ 11▾
No clean pass — all 10 investors flag at least one cash flow criterion
Free Cash Flow Proxy✗BuffettPositive and growingFCF Positive and Growing$-18.4M✗LynchPositive and growingOperating Cash Flow$-13.1M✗PiotroskiCFO > 0(CFO / Total Assets) vs ROACFO/Assets=-2.81%, ROA=-4.87%✓PiotroskiCFO/Assets > ROAPrice / (CFO / Shares)N/A (negative CFPS)✗Dreman< 8xP/E or FCF YieldFCF Yield=-1.6%✗PabraiP/E < 15 or FCF Yield > 10%FCF Positive0/15 years FCF positive✗MarksPositive FCF in majority of recent years(OCF - CapEx) / Market Cap-2.4%✗Ackman>= 4%Price / FCF per ShareN/A (negative FCF)✗Ackman<= 25Positive Operating Cash Flow frequency0/15 years positive✗SleepPositive OCF in >= 70% of available yearsOperating Cash Flow - Capital Expenditures$-18.4M✗Neff> $0 (app proxy for a strong fundamental case)(Operating cash flow - capex) / market capitalization-2.24%; #2776/4519 (top 61.4%)✗OshaughnessyTop 10% of eligible cross-section - Profitability6% pass✓ 6✗ 29▾
15 of 16 flag ESPR's profitability — Graham, Buffett, Lynch +12 more
Positive EPS (10 years)0/16 years positive✗GrahamPositive EPS every year for 10 yearsEPS Growth (3-yr avg, 10-yr window)✗Graham>= 33% growthNet Income Positive (10+ years)0/16 years positive✗BuffettPositive every year for 10+ yearsROE (up to 5-year arithmetic mean)-172.1%✗Buffett> 15% arithmetic mean (app rule)Operating Margin (10-yr trend)15.0% (latest)✓BuffettStable or rising over 10 yearsFree Cash Flow Proxy✗BuffettPositive and growingEarnings Variance (10-yr CoV)✗BuffettCoV < 0.3Retained Earnings Effectiveness✗Buffett$1 retained -> > $1 market value createdBasic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)3-5 Year EPS CAGR✗Lynch15-30% (Fast Grower); > 0% to passROEN/A (negative equity)✗Lynch> 15%EBIT / Enterprise Value9.2%✗Greenblatt> 10%Earnings Yield + ROC AssessmentEY=9.2%, ROC=N/A (invested capital <= 0)✗GreenblattBoth EY > 10% and ROC > 25%Net Income / Total Assets-4.87%✗PiotroskiROA > 0ROA Change YoY-15.05% -> -4.87% (delta: +10.18%)✓PiotroskiCurrent ROA > Prior ROA(CFO / Total Assets) vs ROACFO/Assets=-2.81%, ROA=-4.87%✓PiotroskiCFO/Assets > ROAGross Margin Change YoY✗PiotroskiImproved YoYPre-Tax Income / Revenue-5.2%✗Dreman>= 8%Net Income / Shareholders' Equity✗Dreman> 12%Margin of Safety✗PabraiP/B < 1.5 or P/E < 15Return on Equity-270.1% (3-yr avg)✗AkreROE > 20% (3-year avg)Discount to Intrinsic ValueN/A (negative normalized EPS)✗Marks>= 20% below intrinsic valuePositive Net Income Frequency0/15 years positive✗MarksPositive net income in >= 7 of last 10 yearsOperating Income / Revenue18.1%✓Ackman>= 15%Net Income / Shareholders Equity✗Ackman>= 15%5-Year EPS CAGR✗Templeton> 0% (5-year EPS CAGR)Operating Margin Trend-133.7% (2023) -> 15.0% (2025)✓TempletonNon-negative operating-margin trend over 3 yearsRevenue growth vs. gross and operating margin trendrevenue up, operating margin -133.7% -> 15.0%✓SleepRevenue rising; gross margin flat or falling; operating margin holdingNet income / market capitalization-0.91%; #3393/6340 (top 53.5%)✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-sectionGross profit / total assets✗AsnessTop 30% of eligible cross-sectionNet income / positive book equity✗AsnessTop 30% of eligible cross-sectionNegative 5-year standard deviation of ROA-0.4011; #4803/5884 (top 81.6%)✗AsnessTop 30% of eligible cross-section3-5 Year Diluted EPS CAGR✗Neff7%-20% annualizedPositive Diluted-EPS Years0/10 years positive✗Schloss>= 70% positive over 5-10 observed years (app rule) - Efficiency13% pass✓ 2✗ 9▾
7 of 8 flag ESPR's efficiency — Graham, Buffett, Greenblatt +4 more
Current Ratio1.53✗Graham>= 2.0ROIC (3-5 yr avg)-41.6%✗Buffett> 10%ROIC - WACC-51.6%✗BuffettPositive (WACC = 10%)EBIT / (NWC + Net Fixed Assets)N/A (invested capital <= 0)✗Greenblatt> 25%Current Ratio Change YoY1.37 -> 1.54✓PiotroskiIncreased YoYRevenue / Total Assets Change YoY0.97x -> 0.87x✗PiotroskiImproved YoYCurrent Assets / Current Liabilities1.53✓Dreman> 1.5Return on Invested CapitalN/A (non-positive invested capital)✗Munger> 15%ROIC (high and growing)FY2023: ROIC=unavailable; FY2024: ROIC=unavailable; FY2025: ROIC=unavailable✗AkreLatest 3 consecutive FYs: ROIC > 15% in eachReinvestment Rate x ROIC✗AkreReinvestment Rate * ROIC > 10%ROIC (5-year)✗SleepROIC > 12% in a majority of years - Debt & Leverage17% pass✓ 4✗ 11▾
10 of 12 flag ESPR's debt & leverage — Graham, Buffett, Lynch +7 more
LT Debt vs Net Current Assets✗GrahamLT Debt <= Net Current AssetsDebt/Equity & Interest CoverageD/E: N/A (negative equity), IC: 3.7x✗BuffettD/E < 0.5 AND Interest Coverage > 5xTotal Debt / EquityN/A (negative equity)✗Lynch< 0.33Cash - Long-term Debt✗LynchPositive preferredLT Debt / Total Assets Change0.00% -> 0.00%✓PiotroskiDecreased YoYCurrent Assets / Current Liabilities1.53✓Dreman> 1.5✓SchlossCurrent ratio >= 1.50x (app cutoff)Total Debt / Shareholders' Equity✗Dreman< 0.8✗Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✗SchlossD/E < 1.00xDebt LevelsN/A (non-positive equity)✗MungerDebt/Equity < 0.5✗AkreDebt/Equity < 0.3Interest Coverage & Debt/EBITDAIC=3.7x, D/EBITDA=0.0x (no debt)✓MarksInterest Coverage > 3x; Debt/EBITDA < 4xTotal Debt / Shareholders Equity✗Ackman<= 1.0Negative debt-to-equity (higher means less debt)✗AsnessTop 30% of eligible cross-section - Verdicts21% pass✓ 3✗ 11▾
Split decision: 11 FAIL · 3 PASS · 2 NEUTRAL
Overall verdict✗GrahamFAIL (1/9)✗BuffettFAIL (1/9)✗LynchFAIL (1/7)•GreenblattNot ranked✓PiotroskiPASS (F-Score 4)✗DremanFAIL (1/11)✗MungerFAIL (0/4)✗PabraiFAIL (0/3)✗AkreFAIL (1/6)✗MarksFAIL (1/5)✓AckmanPASS (4/9)✗TempletonFAIL (2/8)✓SleepPASS (3/6)•AsnessNEUTRAL (Not ranked)✗NeffFAIL (1/6)✗SchlossFAIL (1/7)•OshaughnessyNEUTRAL (Not ranked) - Growth25% pass✓ 5✗ 8▾
6 of 8 flag ESPR's growth — Graham, Lynch, Dreman +3 more
EPS Growth (3-yr avg, 10-yr window)✗Graham>= 33% growthBasic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)3-5 Year EPS CAGR✗Lynch15-30% (Fast Grower); > 0% to passInventory Growth vs Revenue GrowthInv: 4.9% vs Rev: 61.1%✓LynchInventory growth < Revenue growthEPS Growth Direction✗DremanPositive over recent yearsEPS CAGR✗Dreman> 5% annualizedPositive Net Income Frequency0/15 years positive✗MarksPositive net income in >= 7 of last 10 years3yr Median Revenue Growth54.1%✓Ackman>= 5%Positive EPS Growth Frequency4/5 years with positive EPS growth✓AckmanPositive EPS growth in >= 3 of last 5 years5-Year EPS CAGR✗Templeton> 0% (5-year EPS CAGR)Revenue growth vs. gross and operating margin trendrevenue up, operating margin -133.7% -> 15.0%✓SleepRevenue rising; gross margin flat or falling; operating margin holding5-year Revenue CAGR12.1%✓SleepCAGR > 7%3-5 Year Diluted EPS CAGR✗Neff7%-20% annualized
Business & financials
Financial snapshot: annual FY 2025. Current investor scores may use newer quarterly data.
Company Profile
Financial Snapshot
Shareholder Return
Fiscal 2025
Issued 24.6% of shares last year, 107.4% issued over two.
- Buybacks
- —
- Dividends
- —
Company Financials
Latest TTM and quarters alongside annual years
TTM sums four consecutive quarters and uses the latest quarter-end balances. Quarter columns show three-month results; annual columns show full-year totals. Growth compares the same period a year earlier. EPS is not added for TTM; full-year ratios are blank for quarters.
The latest annual period end is unavailable. Showing the latest fiscal cycle’s quarters; quarter and annual columns may overlap. Quarterly shows the full quarter history.
| Metric | TTM · 2026-03-31 2025-04-01 – 2026-03-31 Sources · derived quarter valuesDerived from cumulative filings: operating cash flow, capex, revenue, net income, operating income, ebit, interest expense. | Q1 FY 2026 2026-01-01 – 2026-03-31 Sources | FY 2025Sources
| FY 2024Sources
| FY 2023Sources
| FY 2022Sources
| FY 2021Sources
|
|---|---|---|---|---|---|---|---|
| Market Cap | $819.5Mcurrent | -- | $831.3Mest. | $352.4Mest. | $253.0Mest. | $474.3Mest. | $124.0Mest. |
| Revenue | $418.2M↑61% | $80.1M↑23% | $403.1M↑21% | $332.3M↑186% | $116.3M↑54% | $75.5M↓4% | $78.4M |
| Operating Income | $75.8M↑290% | -$6.6M↑70% | $60.3M↑11% | $54.4M↑135% | -$155.6M↑13% | -$179.5M↑21% | -$226.7M |
| Net Income | -$7.4M↑95% | -$25.2M↑38% | -$22.7M↑56% | -$51.7M↑75% | -$209.2M↑10% | -$233.7M↑13% | -$269.1M |
| EPS (Diluted) | -- | $-0.10↑52% | $-0.11↑61% | $-0.28↑86% | $-2.03↑42% | $-3.52↑62% | $-9.31 |
| Gross Margin | — | — | — | — | — | — | — |
| Operating Margin | 18.1%↑218% | -8.2%↑76% | 15.0%↓9% | 16.4%↑112% | -133.7%↑44% | -237.8%↑18% | -289.0% |
| ROE | 2.4%↓93% | — | 7.5%↓44% | 13.3%↓71% | 46.0%↓36% | 72.2%↓47% | 136.6% |
| Total Debt | -- | -- | $0↓100% | $54.6M | $0 | -- | -- |
| Shareholders' Equity | -$307.9M↑28% | -$307.9M↑28% | -$302.0M↑22% | -$388.7M↑15% | -$455.0M↓41% | -$323.8M↓64% | -$196.9M |
| Current Ratio | 1.53↑30% | 1.53↑30% | 1.54↑12% | 1.37↑7% | 1.29↓52% | 2.67↓40% | 4.48 |
| Debt / Equity | — | — | 0.00↑100% | -0.14 | 0.00 | — | — |
| Operating Cash Flow | -$18.2M↑82% | -$27.7M↓23% | -$13.1M↑45% | -$23.7M↑83% | -$135.5M↑23% | -$174.8M↑34% | -$263.8M |
| Free Cash Flow | -$18.4M↑82% | -$27.9M↓23% | -$13.1M↑45% | -$24.0M↑82% | -$135.5M↑23% | -$174.8M↑34% | -$263.8M |
Score history
Historical Score Timeline
Industry peers
Industry Peers
Similar companies in Pharmaceutical Products
ESPR vs Peers — Financial Grading
| Company | Market Cap | Price | Revenue | Net Income | ROE | D/E | Op. Margin | Curr. Ratio | Graham | Buffett | Lynch | Greenblatt | Piotroski | Dreman |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Merck & Co., Inc.MRK | $364.3B | $147.76 | $65.0B | $18.3B | 34.7% | 0.94 | — | 1.54 | 2/9 | 5/9 | 4/7 | 0/3 | F-Score 4 | 1/11 |
| ABBOTT LABORATORIESABT | $188.0B | $108.52 | $44.3B | $6.5B | 12.5% | 0.25 | 18.2% | 1.58 | 3/9 | 4/9 | 2/7 | 1/3 | F-Score 5 | 3/11 |
| BRISTOL MYERS SQUIBB COBMY | $129.7B | $63.43 | $48.2B | $7.1B | 38.2% | 2.44 | 19.4% | 1.26 | 2/9 | 1/9 | 3/7 | 1/3 | F-Score 8 | 5/11 |
| BIO-TECHNE CorpTECH | $11.4B | $72.80 | $1.2B | $73.4M | 3.8% | — | 8.4% | 3.46 | 4/9 | 3/9 | 3/7 | 0/3 | F-Score 5 | 4/11 |
| REPLIGEN CORPRGEN | $10.7B | $167.79 | $738.3M | $48.9M | 2.3% | 0.26 | 7.5% | 8.37 | 3/9 | 2/9 | 3/7 | 0/3 | F-Score 7 | 5/11 |
| IONIS PHARMACEUTICALS INCIONS | $4.8B | $29.06 | $943.7M | $381.4M | -78.0% | 3.60 | -40.4% | 3.83 | 3/9 | 1/9 | 1/7 | 0/3 | F-Score 4 | 3/11 |
| NEOGEN CORPNEOG | $2.5B | $11.23 | $870.4M | $7.9M | -0.4% | 0.76 | -2.5% | 3.82 | 3/9 | 1/9 | 2/7 | 0/3 | F-Score 6 | 4/11 |
| Pharvaris N.V.PHVS | $2.4B | $33.36 | — | $206.4M | -64.8% | 0.00 | — | — | 0/9 | 0/9 | 2/7 | 0/3 | F-Score 2 | 2/11 |