Esperion Therapeutics, Inc.

ESPR
About the company

Esperion Therapeutics, Inc., a biopharmaceutical company, develops and commercializes medicines for the treatment of patients with elevated low density lipoprotein cholesterol (LDL-C) in the United States. The company's marketed products include NEXLETOL (bempedoic acid) and NEXLIZET (bempedoic acid and ezetimibe) tablets that are oral, once-daily, non-statin medicines for the treatment of primary hyperlipidemia in adults with heterozygous familial hypercholesterolemia cardiovascular disease who require additional lowering of LDL-C.

Country: United StatesPrice: $3.18Market Cap: $819.5M

Investment snapshot

18%positive consensus
Scored 1d ago

Positive

3

BUY / PASS

Neutral / negative

2 / 11

NEUTRAL / FAIL

Median fair value

—

No comparable estimates

Models with upside

0 / 17

Positive margin of safety

Key risk

All 13 investors flag ESPR's valuation

Framework analysis

VerdictMeaning
BUYPositive purchase signal: the framework's buy requirements are met.
PASSThe company clears the framework's checklist or screen, but the framework does not produce a buy signal. For valuation frameworks this often means margin of safety is missing, insufficient, or unavailable; some screen-only frameworks have no intrinsic-value BUY state.
NEUTRALNeither a positive nor negative conclusion. It does not mean to hold an existing position.
FAILThe company does not clear the framework's requirements.
RankedRanked strategies do not use PASS: selected cohort is BUY, outside the cohort is FAIL, and unranked is NEUTRAL.

Current investor scores use trailing 12-month flows and the latest balance sheet where supported. Multi-year and EPS tests retain annual history; each framework shows its financial basis below. Intrinsic values use annual financials.

MetricGraham

Defensive Value

Buffett

Quality Compounder

Lynch

GARP

Greenblatt

Magic Formula

Piotroski

F-Score

Dreman

Contrarian Value

Munger

Quality Focus

Pabrai

Dhandho Framework

Akre

Three-Legged Stool

Marks

Risk-Aware Value

Ackman

Activist Value

Templeton

Global Bargain Hunter

Sleep

Scale Economies Shared

Asness

Systematic Factors

Neff

Low-P/E Total Return

Schloss

Asset-Value Discipline

O'Shaughnessy

Systematic Factor Composite

VerdictFAILFAILFAILNot rankedPASSFAILFAILFAILFAILFAILPASSFAILPASSNEUTRALFAILFAILNEUTRAL
Score
AnalysisChecking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…Checking access…
Intrinsic Value (annual)N/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/A
Margin of SafetyN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/A
Financial Basis

TTM ended 2026-03-31 · Balance sheet at 2026-03-31 · Annual history · FY 2025

Latest source filing: 2026-05-08

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-10

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-03-31 vs 2025-03-31 · TTM ended 2026-03-31

Latest source filing: 2026-05-08

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-10

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-10

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-03-31 · Balance sheet at 2026-03-31 · Market data at 2026-09-01

Latest source filing: 2026-05-08

Score computed: 2026-11-14

Qualitative assessment · Annual history · FY 2025

Latest source filing: 2026-03-10

Score computed: 2026-11-14

Qualitative assessment · Annual history · FY 2025

Latest source filing: 2026-03-10

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment · TTM ended 2026-03-31

Latest source filing: 2026-05-08

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment

Latest source filing: 2026-03-10

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-03-31 · Market data at 2026-09-01

Latest source filing: 2026-05-08

Score computed: 2026-11-14

Annual history · FY 2025 · Price history 2025-01-01–2026-09-01

Latest source filing: 2026-03-10

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment

Latest source filing: 2026-03-10

Score computed: 2026-11-14

TTM ended 2026-03-31 · Balance sheet at 2026-03-31 · Price history 2025-01-01–2026-09-01 · Annual history · FY 2025

Latest source filing: 2026-05-08

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-03-31

Latest source filing: 2026-05-08

Score computed: 2026-11-14

Annual history · FY 2025 · Balance sheet at 2026-03-31

Latest source filing: 2026-05-08

Score computed: 2026-11-14

TTM ended 2026-03-31 · Annual history · FY 2025 · Price history 2025-01-01–2026-09-01

Latest source filing: 2026-05-08

Score computed: 2026-11-14

Where It Passes

    Where It Falls Short

    • Valuation0% pass✗ 28▾

      All 13 investors flag ESPR's valuation

      Price / 3-yr avg EPS
      ✗Graham<= 15x
      Price-to-Book Ratio
      ✗Graham<= 1.5x
      P/E x P/B
      ✗Graham<= 22.5
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      EBIT / Enterprise Value9.2%
      ✗Greenblatt> 10%
      Earnings Yield + ROC AssessmentEY=9.2%, ROC=N/A (invested capital <= 0)
      ✗GreenblattBoth EY > 10% and ROC > 25%
      Price / EPS
      ✗Dreman< 12x✗Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)
      Price / (CFO / Shares)N/A (negative CFPS)
      ✗Dreman< 8x
      Price / Book Value per ShareN/A (negative BVPS)
      ✗Dreman< 1.2x✗Templeton< 1.5x✗SchlossP/B <= 0.80x (app cutoff)
      Valuation Reasonableness
      ✗MungerP/E < 25 or Owner Earnings Yield > 5%
      P/E or FCF YieldFCF Yield=-1.6%
      ✗PabraiP/E < 15 or FCF Yield > 10%
      P/B or P/E vs. Historical Average
      ✗MarksP/E < 15 or P/B < 2.0
      Discount to Intrinsic ValueN/A (negative normalized EPS)
      ✗Marks>= 20% below intrinsic value
      Price / FCF per ShareN/A (negative FCF)
      ✗Ackman<= 25
      Price vs. Trailing Low
      ✗Templeton<= 120% of trailing low (certified split-adjusted live window)
      Net income / market capitalization-0.91%; #3393/6340 (top 53.5%)
      ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
      Positive book equity / market capitalization-0.3758; #5913/6449 (top 91.7%)
      ✗AsnessTop 30% of eligible cross-section
      Price / Diluted EPS
      ✗NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)
      (EPS CAGR % + Dividend Yield %) / P/E
      ✗Neff> 0.7 (Neff's published traditional edge)
      Price / Tangible Book Value per ShareN/A (non-positive TBVPS)
      ✗SchlossP/TBV <= 1.00x (app cutoff)
      Book Value per Share Change
      ✗SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)
      Revenue / market capitalization+0.5104; #2603/5247 (top 49.6%)
      ✗OshaughnessyTop 10% of eligible cross-section
      (Operating cash flow - capex) / market capitalization-2.24%; #2776/4519 (top 61.4%)
      ✗OshaughnessyTop 10% of eligible cross-section
      Trailing six-month price return through the evaluation date
      ✗OshaughnessyTop 10% of eligible cross-section
    • Cash Flow0% pass✓ 1✗ 11▾

      No clean pass — all 10 investors flag at least one cash flow criterion

      Free Cash Flow Proxy
      ✗BuffettPositive and growing
      FCF Positive and Growing$-18.4M
      ✗LynchPositive and growing
      Operating Cash Flow$-13.1M
      ✗PiotroskiCFO > 0
      (CFO / Total Assets) vs ROACFO/Assets=-2.81%, ROA=-4.87%
      ✓PiotroskiCFO/Assets > ROA
      Price / (CFO / Shares)N/A (negative CFPS)
      ✗Dreman< 8x
      P/E or FCF YieldFCF Yield=-1.6%
      ✗PabraiP/E < 15 or FCF Yield > 10%
      FCF Positive0/15 years FCF positive
      ✗MarksPositive FCF in majority of recent years
      (OCF - CapEx) / Market Cap-2.4%
      ✗Ackman>= 4%
      Price / FCF per ShareN/A (negative FCF)
      ✗Ackman<= 25
      Positive Operating Cash Flow frequency0/15 years positive
      ✗SleepPositive OCF in >= 70% of available years
      Operating Cash Flow - Capital Expenditures$-18.4M
      ✗Neff> $0 (app proxy for a strong fundamental case)
      (Operating cash flow - capex) / market capitalization-2.24%; #2776/4519 (top 61.4%)
      ✗OshaughnessyTop 10% of eligible cross-section
    • Profitability6% pass✓ 6✗ 29▾

      15 of 16 flag ESPR's profitability — Graham, Buffett, Lynch +12 more

      Positive EPS (10 years)0/16 years positive
      ✗GrahamPositive EPS every year for 10 years
      EPS Growth (3-yr avg, 10-yr window)
      ✗Graham>= 33% growth
      Net Income Positive (10+ years)0/16 years positive
      ✗BuffettPositive every year for 10+ years
      ROE (up to 5-year arithmetic mean)-172.1%
      ✗Buffett> 15% arithmetic mean (app rule)
      Operating Margin (10-yr trend)15.0% (latest)
      ✓BuffettStable or rising over 10 years
      Free Cash Flow Proxy
      ✗BuffettPositive and growing
      Earnings Variance (10-yr CoV)
      ✗BuffettCoV < 0.3
      Retained Earnings Effectiveness
      ✗Buffett$1 retained -> > $1 market value created
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      3-5 Year EPS CAGR
      ✗Lynch15-30% (Fast Grower); > 0% to pass
      ROEN/A (negative equity)
      ✗Lynch> 15%
      EBIT / Enterprise Value9.2%
      ✗Greenblatt> 10%
      Earnings Yield + ROC AssessmentEY=9.2%, ROC=N/A (invested capital <= 0)
      ✗GreenblattBoth EY > 10% and ROC > 25%
      Net Income / Total Assets-4.87%
      ✗PiotroskiROA > 0
      ROA Change YoY-15.05% -> -4.87% (delta: +10.18%)
      ✓PiotroskiCurrent ROA > Prior ROA
      (CFO / Total Assets) vs ROACFO/Assets=-2.81%, ROA=-4.87%
      ✓PiotroskiCFO/Assets > ROA
      Gross Margin Change YoY
      ✗PiotroskiImproved YoY
      Pre-Tax Income / Revenue-5.2%
      ✗Dreman>= 8%
      Net Income / Shareholders' Equity
      ✗Dreman> 12%
      Margin of Safety
      ✗PabraiP/B < 1.5 or P/E < 15
      Return on Equity-270.1% (3-yr avg)
      ✗AkreROE > 20% (3-year avg)
      Discount to Intrinsic ValueN/A (negative normalized EPS)
      ✗Marks>= 20% below intrinsic value
      Positive Net Income Frequency0/15 years positive
      ✗MarksPositive net income in >= 7 of last 10 years
      Operating Income / Revenue18.1%
      ✓Ackman>= 15%
      Net Income / Shareholders Equity
      ✗Ackman>= 15%
      5-Year EPS CAGR
      ✗Templeton> 0% (5-year EPS CAGR)
      Operating Margin Trend-133.7% (2023) -> 15.0% (2025)
      ✓TempletonNon-negative operating-margin trend over 3 years
      Revenue growth vs. gross and operating margin trendrevenue up, operating margin -133.7% -> 15.0%
      ✓SleepRevenue rising; gross margin flat or falling; operating margin holding
      Net income / market capitalization-0.91%; #3393/6340 (top 53.5%)
      ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
      Gross profit / total assets
      ✗AsnessTop 30% of eligible cross-section
      Net income / positive book equity
      ✗AsnessTop 30% of eligible cross-section
      Negative 5-year standard deviation of ROA-0.4011; #4803/5884 (top 81.6%)
      ✗AsnessTop 30% of eligible cross-section
      3-5 Year Diluted EPS CAGR
      ✗Neff7%-20% annualized
      Positive Diluted-EPS Years0/10 years positive
      ✗Schloss>= 70% positive over 5-10 observed years (app rule)
    • Efficiency13% pass✓ 2✗ 9▾

      7 of 8 flag ESPR's efficiency — Graham, Buffett, Greenblatt +4 more

      Current Ratio1.53
      ✗Graham>= 2.0
      ROIC (3-5 yr avg)-41.6%
      ✗Buffett> 10%
      ROIC - WACC-51.6%
      ✗BuffettPositive (WACC = 10%)
      EBIT / (NWC + Net Fixed Assets)N/A (invested capital <= 0)
      ✗Greenblatt> 25%
      Current Ratio Change YoY1.37 -> 1.54
      ✓PiotroskiIncreased YoY
      Revenue / Total Assets Change YoY0.97x -> 0.87x
      ✗PiotroskiImproved YoY
      Current Assets / Current Liabilities1.53
      ✓Dreman> 1.5
      Return on Invested CapitalN/A (non-positive invested capital)
      ✗Munger> 15%
      ROIC (high and growing)FY2023: ROIC=unavailable; FY2024: ROIC=unavailable; FY2025: ROIC=unavailable
      ✗AkreLatest 3 consecutive FYs: ROIC > 15% in each
      Reinvestment Rate x ROIC
      ✗AkreReinvestment Rate * ROIC > 10%
      ROIC (5-year)
      ✗SleepROIC > 12% in a majority of years
    • Debt & Leverage17% pass✓ 4✗ 11▾

      10 of 12 flag ESPR's debt & leverage — Graham, Buffett, Lynch +7 more

      LT Debt vs Net Current Assets
      ✗GrahamLT Debt <= Net Current Assets
      Debt/Equity & Interest CoverageD/E: N/A (negative equity), IC: 3.7x
      ✗BuffettD/E < 0.5 AND Interest Coverage > 5x
      Total Debt / EquityN/A (negative equity)
      ✗Lynch< 0.33
      Cash - Long-term Debt
      ✗LynchPositive preferred
      LT Debt / Total Assets Change0.00% -> 0.00%
      ✓PiotroskiDecreased YoY
      Current Assets / Current Liabilities1.53
      ✓Dreman> 1.5✓SchlossCurrent ratio >= 1.50x (app cutoff)
      Total Debt / Shareholders' Equity
      ✗Dreman< 0.8✗Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✗SchlossD/E < 1.00x
      Debt LevelsN/A (non-positive equity)
      ✗MungerDebt/Equity < 0.5✗AkreDebt/Equity < 0.3
      Interest Coverage & Debt/EBITDAIC=3.7x, D/EBITDA=0.0x (no debt)
      ✓MarksInterest Coverage > 3x; Debt/EBITDA < 4x
      Total Debt / Shareholders Equity
      ✗Ackman<= 1.0
      Negative debt-to-equity (higher means less debt)
      ✗AsnessTop 30% of eligible cross-section
    • Verdicts21% pass✓ 3✗ 11▾

      Split decision: 11 FAIL · 3 PASS · 2 NEUTRAL

      Overall verdict
      ✗GrahamFAIL (1/9)✗BuffettFAIL (1/9)✗LynchFAIL (1/7)•GreenblattNot ranked✓PiotroskiPASS (F-Score 4)✗DremanFAIL (1/11)✗MungerFAIL (0/4)✗PabraiFAIL (0/3)✗AkreFAIL (1/6)✗MarksFAIL (1/5)✓AckmanPASS (4/9)✗TempletonFAIL (2/8)✓SleepPASS (3/6)•AsnessNEUTRAL (Not ranked)✗NeffFAIL (1/6)✗SchlossFAIL (1/7)•OshaughnessyNEUTRAL (Not ranked)
    • Growth25% pass✓ 5✗ 8▾

      6 of 8 flag ESPR's growth — Graham, Lynch, Dreman +3 more

      EPS Growth (3-yr avg, 10-yr window)
      ✗Graham>= 33% growth
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      3-5 Year EPS CAGR
      ✗Lynch15-30% (Fast Grower); > 0% to pass
      Inventory Growth vs Revenue GrowthInv: 4.9% vs Rev: 61.1%
      ✓LynchInventory growth < Revenue growth
      EPS Growth Direction
      ✗DremanPositive over recent years
      EPS CAGR
      ✗Dreman> 5% annualized
      Positive Net Income Frequency0/15 years positive
      ✗MarksPositive net income in >= 7 of last 10 years
      3yr Median Revenue Growth54.1%
      ✓Ackman>= 5%
      Positive EPS Growth Frequency4/5 years with positive EPS growth
      ✓AckmanPositive EPS growth in >= 3 of last 5 years
      5-Year EPS CAGR
      ✗Templeton> 0% (5-year EPS CAGR)
      Revenue growth vs. gross and operating margin trendrevenue up, operating margin -133.7% -> 15.0%
      ✓SleepRevenue rising; gross margin flat or falling; operating margin holding
      5-year Revenue CAGR12.1%
      ✓SleepCAGR > 7%
      3-5 Year Diluted EPS CAGR
      ✗Neff7%-20% annualized

    Business & financials

    Financial snapshot: annual FY 2025. Current investor scores may use newer quarterly data.

    Company Profile

    Industry: Pharmaceutical Products
    SIC Sector: Chemicals & Pharmaceuticals
    Size: Small Cap($819.5M)
    Revenue: $403.1M+21.3% YoY
    Net Income: $22.7M+56.2% YoY

    Financial Snapshot

    Operating Margin15.0%
    Return on Equity7.5%
    Debt / Equity0.00
    Current Ratio1.54
    EPS (Diluted)$-0.11
    Shares Retired−24.6% / −107.4% 2y

    Shareholder Return

    Fiscal 2025

    Issued 24.6% of shares last year, 107.4% issued over two.

    Buybacks
    —
    Dividends
    —

    Company Financials

    Latest TTM and quarters alongside annual years

    TTM sums four consecutive quarters and uses the latest quarter-end balances. Quarter columns show three-month results; annual columns show full-year totals. Growth compares the same period a year earlier. EPS is not added for TTM; full-year ratios are blank for quarters.

    The latest annual period end is unavailable. Showing the latest fiscal cycle’s quarters; quarter and annual columns may overlap. Quarterly shows the full quarter history.

    MetricTTM · 2026-03-31

    2025-04-01 – 2026-03-31

    Sources · derived quarter values

    Derived from cumulative filings: operating cash flow, capex, revenue, net income, operating income, ebit, interest expense.

    Q1 FY 2026

    2026-01-01 – 2026-03-31

    Sources
    FY 2025
    Sources
    • 10-K · 2026-03-10
    FY 2024
    Sources
    • 10-K · 2025-03-07
    FY 2023
    Sources
    • 10-K · 2024-02-27
    FY 2022
    Sources
    • 10-K · 2023-02-21
    FY 2021
    Sources
    • 10-K · 2022-02-22
    Market Cap$819.5Mcurrent--$831.3Mest.$352.4Mest.$253.0Mest.$474.3Mest.$124.0Mest.
    Revenue$418.2M↑61%$80.1M↑23%$403.1M↑21%$332.3M↑186%$116.3M↑54%$75.5M↓4%$78.4M
    Operating Income$75.8M↑290%-$6.6M↑70%$60.3M↑11%$54.4M↑135%-$155.6M↑13%-$179.5M↑21%-$226.7M
    Net Income-$7.4M↑95%-$25.2M↑38%-$22.7M↑56%-$51.7M↑75%-$209.2M↑10%-$233.7M↑13%-$269.1M
    EPS (Diluted)--$-0.10↑52%$-0.11↑61%$-0.28↑86%$-2.03↑42%$-3.52↑62%$-9.31
    Gross Margin———————
    Operating Margin18.1%↑218%-8.2%↑76%15.0%↓9%16.4%↑112%-133.7%↑44%-237.8%↑18%-289.0%
    ROE2.4%↓93%—7.5%↓44%13.3%↓71%46.0%↓36%72.2%↓47%136.6%
    Total Debt----$0↓100%$54.6M$0----
    Shareholders' Equity-$307.9M↑28%-$307.9M↑28%-$302.0M↑22%-$388.7M↑15%-$455.0M↓41%-$323.8M↓64%-$196.9M
    Current Ratio1.53↑30%1.53↑30%1.54↑12%1.37↑7%1.29↓52%2.67↓40%4.48
    Debt / Equity——0.00↑100%-0.140.00——
    Operating Cash Flow-$18.2M↑82%-$27.7M↓23%-$13.1M↑45%-$23.7M↑83%-$135.5M↑23%-$174.8M↑34%-$263.8M
    Free Cash Flow-$18.4M↑82%-$27.9M↓23%-$13.1M↑45%-$24.0M↑82%-$135.5M↑23%-$174.8M↑34%-$263.8M

    Score history

    Historical Score Timeline

    Industry peers

    Industry Peers

    Similar companies in Pharmaceutical Products

    ESPR vs Peers — Financial Grading

    Revenue$403.1MBottom 25%
    Net Income$22.7MBottom 25%
    ROE7.5%Median
    D/E0.00Top 25%
    Op. Margin15.0%Median
    Curr. Ratio1.54Median
    CompanyMarket CapPriceRevenueNet IncomeROED/EOp. MarginCurr. RatioGrahamBuffettLynchGreenblattPiotroskiDreman
    Merck & Co., Inc.MRK$364.3B$147.76$65.0B$18.3B34.7%0.94—1.542/95/94/70/3F-Score 41/11
    ABBOTT LABORATORIESABT$188.0B$108.52$44.3B$6.5B12.5%0.2518.2%1.583/94/92/71/3F-Score 53/11
    BRISTOL MYERS SQUIBB COBMY$129.7B$63.43$48.2B$7.1B38.2%2.4419.4%1.262/91/93/71/3F-Score 85/11
    BIO-TECHNE CorpTECH$11.4B$72.80$1.2B$73.4M3.8%—8.4%3.464/93/93/70/3F-Score 54/11
    REPLIGEN CORPRGEN$10.7B$167.79$738.3M$48.9M2.3%0.267.5%8.373/92/93/70/3F-Score 75/11
    IONIS PHARMACEUTICALS INCIONS$4.8B$29.06$943.7M$381.4M-78.0%3.60-40.4%3.833/91/91/70/3F-Score 43/11
    NEOGEN CORPNEOG$2.5B$11.23$870.4M$7.9M-0.4%0.76-2.5%3.823/91/92/70/3F-Score 64/11
    Pharvaris N.V.PHVS$2.4B$33.36—$206.4M-64.8%0.00——0/90/92/70/3F-Score 22/11