LEXICON PHARMACEUTICALS, INC.
LXRXAbout the company
Lexicon Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of pharmaceutical products for the treatment of human disease. The company develops sotagliflozin, an orally-delivered small molecule drug for the treatment of hypertrophic cardiomyopathy, and ZYNQUISTA (sotagliflozin) for the treatment of type 1 diabetes.
Investment snapshot
Positive
1
BUY / PASS
Neutral / negative
1 / 14
NEUTRAL / FAIL
Median fair value
—
No comparable estimates
Models with upside
0 / 17
Positive margin of safety
Strongest signal
7 of 12 pass — Buffett, Lynch, Akre +2 more object
Key risk
No clean pass — all 16 investors flag at least one profitability criterion
Framework analysis
| Verdict | Meaning |
|---|---|
| BUY | Positive purchase signal: the framework's buy requirements are met. |
| PASS | The company clears the framework's checklist or screen, but the framework does not produce a buy signal. For valuation frameworks this often means margin of safety is missing, insufficient, or unavailable; some screen-only frameworks have no intrinsic-value BUY state. |
| NEUTRAL | Neither a positive nor negative conclusion. It does not mean to hold an existing position. |
| FAIL | The company does not clear the framework's requirements. |
| Ranked | Ranked strategies do not use PASS: selected cohort is BUY, outside the cohort is FAIL, and unranked is NEUTRAL. |
Current investor scores use trailing 12-month flows and the latest balance sheet where supported. Multi-year and EPS tests retain annual history; each framework shows its financial basis below. Intrinsic values use annual financials.
| Metric | Graham Defensive Value | Buffett Quality Compounder | Lynch GARP | Greenblatt Magic Formula | Piotroski F-Score | Dreman Contrarian Value | Munger Quality Focus | Pabrai Dhandho Framework | Akre Three-Legged Stool | Marks Risk-Aware Value | Ackman Activist Value | Templeton Global Bargain Hunter | Sleep Scale Economies Shared | Asness Systematic Factors | Neff Low-P/E Total Return | Schloss Asset-Value Discipline | O'Shaughnessy Systematic Factor Composite |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Verdict | FAIL | FAIL | FAIL | FAIL · Rank #2253 (Top 72.7%) | PASS | FAIL | FAIL | FAIL | FAIL | FAIL | FAIL | FAIL | FAIL | FAIL | FAIL | FAIL | NEUTRAL |
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| Analysis | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… | Checking access… |
| Intrinsic Value (annual) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Margin of Safety | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Financial Basis | TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Annual history · FY 2025 Latest source filing: 2026-11-05 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-05 Score computed: 2026-11-14 | Annual history · FY 2025 · Balance sheet at 2026-09-30 · TTM ended 2026-09-30 vs 2025-09-30 · TTM ended 2026-09-30 Latest source filing: 2026-11-05 Score computed: 2026-11-14 | TTM ended 2026-09-30 Latest source filing: 2026-11-05 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-05 Score computed: 2026-11-14 | Annual history · FY 2025 · TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Market data at 2026-11-01 Latest source filing: 2026-11-05 Score computed: 2026-11-14 | Qualitative assessment · Annual history · FY 2025 · TTM ended 2026-09-30 · Balance sheet at 2026-09-30 Latest source filing: 2026-11-05 Score computed: 2026-11-14 | Qualitative assessment · Annual history · FY 2025 Latest source filing: 2026-03-05 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment · Balance sheet at 2026-09-30 Latest source filing: 2026-11-05 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-05 Score computed: 2026-11-14 | Annual history · FY 2025 · TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Market data at 2026-11-01 Latest source filing: 2026-11-05 Score computed: 2026-11-14 | Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 · Balance sheet at 2026-09-30 Latest source filing: 2026-11-05 Score computed: 2026-11-14 | Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-03-05 Score computed: 2026-11-14 | TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Price history 2025-01-01–2026-11-01 · Annual history · FY 2025 Latest source filing: 2026-11-05 Score computed: 2026-11-14 | Annual history · FY 2025 Latest source filing: 2026-03-05 Score computed: 2026-11-14 | Annual history · FY 2025 · Balance sheet at 2026-09-30 Latest source filing: 2026-11-05 Score computed: 2026-11-14 | TTM ended 2026-09-30 · Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 Latest source filing: 2026-11-05 Score computed: 2026-11-14 |
Where It Passes
- Debt & Leverage58% pass✓ 10✗ 5▾
7 of 12 pass — Buffett, Lynch, Akre +2 more object
Debt Levels0.32✓MungerDebt/Equity < 0.5✗AkreDebt/Equity < 0.3LT Debt vs Net Current AssetsLT Debt $51.9M vs NCA $171.1M✓GrahamLT Debt <= Net Current AssetsDebt/Equity & Interest CoverageD/E: 0.50, IC: -5.9x✗BuffettD/E < 0.5 AND Interest Coverage > 5xTotal Debt / Equity0.32✓Lynch< 0.33Cash - Long-term Debt$-7.8M✗LynchPositive preferredLT Debt / Total Assets Change33.61% -> 26.71%✓PiotroskiDecreased YoYCurrent Assets / Current Liabilities10.63✓Dreman> 1.5✓SchlossCurrent ratio >= 1.50x (app cutoff)Total Debt / Shareholders' Equity0.32✓Dreman< 0.8✓Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✓SchlossD/E < 1.00xInterest Coverage & Debt/EBITDAIC=-5.9x, D/EBITDA=N/A✗MarksInterest Coverage > 3x; Debt/EBITDA < 4xTotal Debt / Shareholders Equity0.32✓Ackman<= 1.0Negative debt-to-equity (higher means less debt)-0.3167; #2045/4210 (top 48.6%)✗AsnessTop 30% of eligible cross-section
Where It Falls Short
- Profitability0% pass✓ 3✗ 32▾
No clean pass — all 16 investors flag at least one profitability criterion
Positive EPS (10 years)1/24 years positive✗GrahamPositive EPS every year for 10 yearsEPS Growth (3-yr avg, 10-yr window)✗Graham>= 33% growthNet Income Positive (10+ years)1/24 years positive✗BuffettPositive every year for 10+ yearsROE (up to 5-year arithmetic mean)-107.7%✗Buffett> 15% arithmetic mean (app rule)Operating Margin (10-yr trend)-98.2% (latest)✗BuffettStable or rising over 10 yearsFree Cash Flow Proxy$-49.7M✗BuffettPositive and growingEarnings Variance (10-yr CoV)✗BuffettCoV < 0.3Retained Earnings Effectiveness✗Buffett$1 retained -> > $1 market value createdBasic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)3-5 Year EPS CAGR✗Lynch15-30% (Fast Grower); > 0% to passROE-38.1%✗Lynch> 15%EBIT / Enterprise Value-7.1%✗Greenblatt> 10%Earnings Yield + ROC AssessmentEY=-7.1%, ROC=-44.2%✗GreenblattBoth EY > 10% and ROC > 25%Net Income / Total Assets-27.21%✗PiotroskiROA > 0ROA Change YoY-67.15% -> -27.21% (delta: +39.94%)✓PiotroskiCurrent ROA > Prior ROA(CFO / Total Assets) vs ROACFO/Assets=-36.68%, ROA=-27.21%✗PiotroskiCFO/Assets > ROAGross Margin Change YoY98.0% -> 99.4%✓PiotroskiImproved YoYPre-Tax Income / Revenue✗Dreman>= 8%Net Income / Shareholders' Equity-38.1%✗Dreman> 12%Margin of SafetyP/B=6.0x✗PabraiP/B < 1.5 or P/E < 15Return on Equity-124.8% (3-yr avg)✗AkreROE > 20% (3-year avg)Discount to Intrinsic Value✗Marks>= 20% below intrinsic valuePositive Net Income Frequency1/17 years positive✗MarksPositive net income in >= 7 of last 10 yearsOperating Income / Revenue-147.4%✗Ackman>= 15%Net Income / Shareholders Equity-38.1%✗Ackman>= 15%5-Year EPS CAGR✗Templeton> 0% (5-year EPS CAGR)Operating Margin Trend-14265.0% (2023) -> -98.2% (2025)✓TempletonNon-negative operating-margin trend over 3 yearsRevenue growth vs. gross and operating margin trendgross margin 92.9% -> 99.4%, operating margin -14265.0% -> -98.2%✗SleepRevenue rising; gross margin flat or falling; operating margin holdingNet income / market capitalization-7.82%; #4071/6340 (top 64.2%)✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-sectionGross profit / total assets+26.77%; #1606/3702 (top 43.4%)✗AsnessTop 30% of eligible cross-sectionNet income / positive book equity-38.06%; #4049/5226 (top 77.5%)✗AsnessTop 30% of eligible cross-sectionNegative 5-year standard deviation of ROA-0.1713; #4065/5884 (top 69.1%)✗AsnessTop 30% of eligible cross-section3-5 Year Diluted EPS CAGR✗Neff7%-20% annualizedPositive Diluted-EPS Years1/10 years positive✗Schloss>= 70% positive over 5-10 observed years (app rule) - Valuation0% pass✗ 28▾
All 13 investors flag LXRX's valuation
Price / 3-yr avg EPS✗Graham<= 15xPrice-to-Book Ratio6.0x✗Graham<= 1.5xP/E x P/B✗Graham<= 22.5Basic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)EBIT / Enterprise Value-7.1%✗Greenblatt> 10%Earnings Yield + ROC AssessmentEY=-7.1%, ROC=-44.2%✗GreenblattBoth EY > 10% and ROC > 25%Price / EPS✗Dreman< 12x✗Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)Price / (CFO / Shares)N/A (negative CFPS)✗Dreman< 8xPrice / Book Value per Share6.0x✗Dreman< 1.2x✗Templeton< 1.5x✗SchlossP/B <= 0.80x (app cutoff)Valuation ReasonablenessOE Yield=-7.6%✗MungerP/E < 25 or Owner Earnings Yield > 5%P/E or FCF YieldFCF Yield=-8.5%✗PabraiP/E < 15 or FCF Yield > 10%P/B or P/E vs. Historical AverageP/B=6.0x✗MarksP/E < 15 or P/B < 2.0Discount to Intrinsic Value✗Marks>= 20% below intrinsic valuePrice / FCF per ShareN/A (negative FCF)✗Ackman<= 25Price vs. Trailing Low389% of trailing low ($0.46)✗Templeton<= 120% of trailing low (certified split-adjusted live window)Net income / market capitalization-7.82%; #4071/6340 (top 64.2%)✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-sectionPositive book equity / market capitalization+0.2056; #4159/6449 (top 64.5%)✗AsnessTop 30% of eligible cross-sectionPrice / Diluted EPS✗NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)(EPS CAGR % + Dividend Yield %) / P/E✗Neff> 0.7 (Neff's published traditional edge)Price / Tangible Book Value per Share10.33x✗SchlossP/TBV <= 1.00x (app cutoff)Book Value per Share Change✗SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)Revenue / market capitalization+0.0484; #4584/5247 (top 87.4%)✗OshaughnessyTop 10% of eligible cross-section(Operating cash flow - capex) / market capitalization-8.51%; #3174/4519 (top 70.2%)✗OshaughnessyTop 10% of eligible cross-sectionTrailing six-month price return through the evaluation date+11.18%; #1795/6202 (top 28.9%)✗OshaughnessyTop 10% of eligible cross-section - Cash Flow0% pass✗ 12▾
All 10 investors flag LXRX's cash flow
Free Cash Flow Proxy$-49.7M✗BuffettPositive and growingFCF Positive and Growing$-67.9M✗LynchPositive and growingOperating Cash Flow$-67.9M✗PiotroskiCFO > 0(CFO / Total Assets) vs ROACFO/Assets=-36.68%, ROA=-27.21%✗PiotroskiCFO/Assets > ROAPrice / (CFO / Shares)N/A (negative CFPS)✗Dreman< 8xP/E or FCF YieldFCF Yield=-8.5%✗PabraiP/E < 15 or FCF Yield > 10%FCF Positive2/17 years FCF positive✗MarksPositive FCF in majority of recent years(OCF - CapEx) / Market Cap-10.4%✗Ackman>= 4%Price / FCF per ShareN/A (negative FCF)✗Ackman<= 25Positive Operating Cash Flow frequency2/17 years positive✗SleepPositive OCF in >= 70% of available yearsOperating Cash Flow - Capital Expenditures$-67.9M✗Neff> $0 (app proxy for a strong fundamental case)(Operating cash flow - capex) / market capitalization-8.51%; #3174/4519 (top 70.2%)✗OshaughnessyTop 10% of eligible cross-section - Growth0% pass✓ 2✗ 11▾
No clean pass — all 8 investors flag at least one growth criterion
EPS Growth (3-yr avg, 10-yr window)✗Graham>= 33% growthBasic earnings-growth PEG (dividends excluded)✗Lynch< 1.0 (ideally < 0.5)3-5 Year EPS CAGR✗Lynch15-30% (Fast Grower); > 0% to passInventory Growth vs Revenue GrowthInv: 663.3% vs Rev: -45.6%✗LynchInventory growth < Revenue growthEPS Growth Direction✗DremanPositive over recent yearsEPS CAGR✗Dreman> 5% annualizedPositive Net Income Frequency1/17 years positive✗MarksPositive net income in >= 7 of last 10 years3yr Median Revenue Growth766.2%✓Ackman>= 5%Positive EPS Growth Frequency✗AckmanPositive EPS growth in >= 3 of last 5 years5-Year EPS CAGR✗Templeton> 0% (5-year EPS CAGR)Revenue growth vs. gross and operating margin trendgross margin 92.9% -> 99.4%, operating margin -14265.0% -> -98.2%✗SleepRevenue rising; gross margin flat or falling; operating margin holding5-year Revenue CAGR15.7%✓SleepCAGR > 7%3-5 Year Diluted EPS CAGR✗Neff7%-20% annualized - Verdicts6% pass✓ 1✗ 15▾
Split decision: 14 FAIL · 1 PASS · 1 NEUTRAL
Overall verdict✗GrahamFAIL (2/9)✗BuffettFAIL (0/9)✗LynchFAIL (1/7)✗GreenblattRank #2253✓PiotroskiPASS (F-Score 4)✗DremanFAIL (2/11)✗MungerFAIL (1/4)✗PabraiFAIL (0/3)✗AkreFAIL (1/6)✗MarksFAIL (0/5)✗AckmanFAIL (3/9)✗TempletonFAIL (3/8)✗SleepFAIL (1/6)✗AsnessFAIL (Rank #1864/2370 (Top 78.6%))✗NeffFAIL (1/6)✗SchlossFAIL (2/7)•OshaughnessyNEUTRAL (Not ranked) - Efficiency25% pass✓ 3✗ 8▾
6 of 8 flag LXRX's efficiency — Buffett, Greenblatt, Piotroski +3 more
Current Ratio10.63✓Graham>= 2.0ROIC (3-5 yr avg)-80.5%✗Buffett> 10%ROIC - WACC-90.5%✗BuffettPositive (WACC = 10%)EBIT / (NWC + Net Fixed Assets)-44.2%✗Greenblatt> 25%Current Ratio Change YoY5.44 -> 4.88✗PiotroskiIncreased YoYRevenue / Total Assets Change YoY0.10x -> 0.27x✓PiotroskiImproved YoYCurrent Assets / Current Liabilities10.63✓Dreman> 1.5Return on Invested Capital-20.8%✗Munger> 15%ROIC (high and growing)FY2023: ROIC=-70.4%; FY2024: ROIC=-63.2%; FY2025: ROIC=-23.9%✗AkreLatest 3 consecutive FYs: ROIC > 15% in eachReinvestment Rate x ROICN/A (non-positive net income)✗AkreReinvestment Rate * ROIC > 10%ROIC (5-year)0/5 years above 12% (latest -23.9%)✗SleepROIC > 12% in a majority of years
Business & financials
Financial snapshot: annual FY 2025. Current investor scores may use newer quarterly data.
Company Profile
Financial Snapshot
Shareholder Return
Fiscal 2025
Issued 0.5% of shares last year.
- Buybacks
- —
- Dividends
- —
Company Financials
Latest TTM and quarters alongside annual years
TTM sums four consecutive quarters and uses the latest quarter-end balances. Quarter columns show three-month results; annual columns show full-year totals. Growth compares the same period a year earlier. EPS is not added for TTM; full-year ratios are blank for quarters.
The latest annual period end is unavailable. Showing the latest fiscal cycle’s quarters; quarter and annual columns may overlap. Quarterly shows the full quarter history.
| Metric | TTM · 2026-09-30 2025-10-01 – 2026-09-30 Sources · derived quarter valuesDerived from cumulative filings: revenue, net income, operating income, ebit, operating cash flow, depreciation amortization, capex. | Q3 FY 2026 2026-07-01 – 2026-09-30 Sources · derived quarter valuesDerived from cumulative filings: operating cash flow, depreciation amortization. | Q2 FY 2026 2026-04-01 – 2026-06-30 Sources · derived quarter valuesDerived from cumulative filings: operating cash flow, depreciation amortization. | Q1 FY 2026 2026-01-01 – 2026-03-31 Sources | FY 2025Sources
| FY 2024Sources
| FY 2023Sources
| FY 2022Sources
| FY 2021Sources
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|---|---|---|---|---|---|---|---|---|---|
| Market Cap | $797.0Mcurrent | -- | -- | -- | $421.6Mest. | $274.7Mest. | $459.2Mest. | $422.7Mest. | $461.7Mest. |
| Revenue | $38.5M↓46% | $11.3M↓21% | $692.0K↓98% | $21.1M↑1572% | $49.8M↑60% | $31.1M↑2481% | $1.2M↑766% | $139.0K↓53% | $298.0K |
| Operating Income | -$56.8M↑15% | -$14.5M↓19% | -$26.5M↓810% | -$996.0K↑96% | -$48.9M↑75% | -$197.1M↓15% | -$171.8M↓70% | -$100.8M↓16% | -$87.1M |
| Net Income | -$62.4M↑9% | -$14.0M↓10% | -$31.8M↓1077% | -$1.0M↑96% | -$50.3M↑75% | -$200.4M↓13% | -$177.1M↓74% | -$101.9M↓16% | -$87.8M |
| EPS (Diluted) | -- | $-0.03↑25% | $-0.07↓800% | $0.00↑100% | $-0.14↑78% | $-0.63↑21% | $-0.80↓29% | $-0.62↓3% | $-0.60 |
| Gross Margin | — | — | — | — | 99.4%↑1% | 98.0%↑5% | 92.9%↓7% | 100.0% | 100.0% |
| Operating Margin | -147.4%↓56% | -128.8%↓50% | -3835.3%↓29733% | -4.7%↑100% | -98.2%↑85% | -634.2%↑96% | -14265.0%↑80% | -72489.2%↓148% | -29224.8% |
| ROE | -38.1%↑33% | — | — | — | -46.8%↑66% | -137.3%↑28% | -190.2%↓119% | -87.0%↓13% | -77.3% |
| Total Debt | $51.9M↓8% | $51.9M↓8% | $51.4M↓8% | $49.7M↓51% | $54.0M↓46% | $100.3M↑1% | $99.5M↑105% | $48.6M | $0 |
| Shareholders' Equity | $163.8M↑36% | $163.8M↑36% | $174.5M↑35% | $202.9M↑65% | $107.5M↓26% | $145.9M↑57% | $93.1M↓21% | $117.1M↑3% | $113.6M |
| Current Ratio | 10.63↑88% | 10.63↑88% | 13.37↑221% | 18.79↑746% | 4.88↓10% | 5.44↓3% | 5.60↓8% | 6.08↑51% | 4.02 |
| Debt / Equity | 0.32↓33% | 0.32↓33% | 0.29↓32% | 0.24↓70% | 0.50↓27% | 0.69↓36% | 1.07↑158% | 0.41 | 0.00 |
| Operating Cash Flow | -$49.2M↑32% | -$8.1M↑66% | -$9.2M↓154% | -$14.7M↑66% | -$67.9M↑62% | -$178.8M↓10% | -$161.9M↓82% | -$88.9M↓2% | -$87.0M |
| Free Cash Flow | -- | -- | -- | -- | -$67.9M↑62% | -$179.8M↓11% | -$162.4M↓80% | -$90.2M↓2% | -$88.2M |
Score history
Historical Score Timeline
Industry peers
Industry Peers
Similar companies in Pharmaceutical Products
LXRX vs Peers — Financial Grading
| Company | Market Cap | Price | Revenue | Net Income | ROE | D/E | Op. Margin | Curr. Ratio | Graham | Buffett | Lynch | Greenblatt | Piotroski | Dreman |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Merck & Co., Inc.MRK | $364.3B | $147.76 | $65.0B | $18.3B | 34.7% | 0.94 | — | 1.54 | 2/9 | 5/9 | 4/7 | 0/3 | F-Score 4 | 1/11 |
| ABBOTT LABORATORIESABT | $188.0B | $108.52 | $44.3B | $6.5B | 12.5% | 0.25 | 18.2% | 1.58 | 3/9 | 4/9 | 2/7 | 1/3 | F-Score 5 | 3/11 |
| BRISTOL MYERS SQUIBB COBMY | $129.7B | $63.43 | $48.2B | $7.1B | 38.2% | 2.44 | 19.4% | 1.26 | 2/9 | 1/9 | 3/7 | 1/3 | F-Score 8 | 5/11 |
| BIO-TECHNE CorpTECH | $11.4B | $72.80 | $1.2B | $73.4M | 3.8% | — | 8.4% | 3.46 | 4/9 | 3/9 | 3/7 | 0/3 | F-Score 5 | 4/11 |
| REPLIGEN CORPRGEN | $10.7B | $167.79 | $738.3M | $48.9M | 2.3% | 0.26 | 7.5% | 8.37 | 3/9 | 2/9 | 3/7 | 0/3 | F-Score 7 | 5/11 |
| IONIS PHARMACEUTICALS INCIONS | $4.8B | $29.06 | $943.7M | $381.4M | -78.0% | 3.60 | -40.4% | 3.83 | 3/9 | 1/9 | 1/7 | 0/3 | F-Score 4 | 3/11 |
| NEOGEN CORPNEOG | $2.5B | $11.23 | $870.4M | $7.9M | -0.4% | 0.76 | -2.5% | 3.82 | 3/9 | 1/9 | 2/7 | 0/3 | F-Score 6 | 4/11 |
| Pharvaris N.V.PHVS | $2.4B | $33.36 | — | $206.4M | -64.8% | 0.00 | — | — | 0/9 | 0/9 | 2/7 | 0/3 | F-Score 2 | 2/11 |