REGENXBIO Inc.

RGNX
About the company

REGENXBIO Inc., a clinical-stage biotechnology company, provides gene therapies that deliver functional genes to cells with genetic defects in the United States. Its gene therapy product candidates are based on NAV Technology Platform, a proprietary adeno-associated virus gene delivery platform.

Country: United StatesPrice: $7.64Market Cap: $505.2M

Investment snapshot

6%positive consensus
Scored 1d ago

Positive

1

BUY / PASS

Neutral / negative

2 / 13

NEUTRAL / FAIL

Median fair value

—

No comparable estimates

Models with upside

0 / 17

Positive margin of safety

Key risk

No clean pass — all 13 investors flag at least one valuation criterion

Framework analysis

VerdictMeaning
BUYPositive purchase signal: the framework's buy requirements are met.
PASSThe company clears the framework's checklist or screen, but the framework does not produce a buy signal. For valuation frameworks this often means margin of safety is missing, insufficient, or unavailable; some screen-only frameworks have no intrinsic-value BUY state.
NEUTRALNeither a positive nor negative conclusion. It does not mean to hold an existing position.
FAILThe company does not clear the framework's requirements.
RankedRanked strategies do not use PASS: selected cohort is BUY, outside the cohort is FAIL, and unranked is NEUTRAL.

Current investor scores use trailing 12-month flows and the latest balance sheet where supported. Multi-year and EPS tests retain annual history; each framework shows its financial basis below. Intrinsic values use annual financials.

MetricGraham

Defensive Value

Buffett

Quality Compounder

Lynch

GARP

Greenblatt

Magic Formula

Piotroski

F-Score

Dreman

Contrarian Value

Munger

Quality Focus

Pabrai

Dhandho Framework

Akre

Three-Legged Stool

Marks

Risk-Aware Value

Ackman

Activist Value

Templeton

Global Bargain Hunter

Sleep

Scale Economies Shared

Asness

Systematic Factors

Neff

Low-P/E Total Return

Schloss

Asset-Value Discipline

O'Shaughnessy

Systematic Factor Composite

VerdictFAILFAILFAILFAIL · Rank #2626 (Top 84.8%)PASSFAILFAILFAILFAILFAILFAILFAILFAILNEUTRALFAILFAILNEUTRAL
Score
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Intrinsic Value (annual)N/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/A
Margin of SafetyN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/AN/A
Financial Basis

TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Annual history · FY 2025

Latest source filing: 2026-11-05

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-05

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-09-30 vs 2025-09-30 · TTM ended 2026-09-30

Latest source filing: 2026-11-05

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-05

Score computed: 2026-11-14

Annual history · FY 2025

Latest source filing: 2026-03-05

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Market data at 2026-11-01

Latest source filing: 2026-11-05

Score computed: 2026-11-14

Qualitative assessment · Annual history · FY 2025

Latest source filing: 2026-03-05

Score computed: 2026-11-14

Qualitative assessment · Annual history · FY 2025

Latest source filing: 2026-03-05

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment · TTM ended 2026-09-30

Latest source filing: 2026-11-05

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment

Latest source filing: 2026-03-05

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-09-30 · Market data at 2026-11-01

Latest source filing: 2026-11-05

Score computed: 2026-11-14

Annual history · FY 2025 · Price history 2025-01-01–2026-11-01

Latest source filing: 2026-03-05

Score computed: 2026-11-14

Annual history · FY 2025 · Qualitative assessment

Latest source filing: 2026-03-05

Score computed: 2026-11-14

TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Price history 2025-01-01–2026-11-01 · Annual history · FY 2025

Latest source filing: 2026-11-05

Score computed: 2026-11-14

Annual history · FY 2025 · TTM ended 2026-09-30

Latest source filing: 2026-11-05

Score computed: 2026-11-14

Annual history · FY 2025 · Balance sheet at 2026-09-30

Latest source filing: 2026-11-05

Score computed: 2026-11-14

TTM ended 2026-09-30 · Annual history · FY 2025 · Price history 2025-01-01–2026-11-01

Latest source filing: 2026-11-05

Score computed: 2026-11-14

Where It Passes

    Where It Falls Short

    • Valuation0% pass✓ 1✗ 27▾

      No clean pass — all 13 investors flag at least one valuation criterion

      Price / 3-yr avg EPS
      ✗Graham<= 15x
      Price-to-Book Ratio3.8x
      ✗Graham<= 1.5x
      P/E x P/B
      ✗Graham<= 22.5
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      EBIT / Enterprise Value-34.2%
      ✗Greenblatt> 10%
      Earnings Yield + ROC AssessmentEY=-34.2%, ROC=-69.0%
      ✗GreenblattBoth EY > 10% and ROC > 25%
      Price / EPS
      ✗Dreman< 12x✗Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)
      Price / (CFO / Shares)N/A (negative CFPS)
      ✗Dreman< 8x
      Price / Book Value per Share3.8x
      ✗Dreman< 1.2x✗Templeton< 1.5x✗SchlossP/B <= 0.80x (app cutoff)
      Valuation ReasonablenessOE Yield=-45.8%
      ✗MungerP/E < 25 or Owner Earnings Yield > 5%
      P/E or FCF YieldFCF Yield=-25.0%
      ✗PabraiP/E < 15 or FCF Yield > 10%
      P/B or P/E vs. Historical AverageP/B=3.8x
      ✗MarksP/E < 15 or P/B < 2.0
      Discount to Intrinsic ValueN/A (negative normalized EPS)
      ✗Marks>= 20% below intrinsic value
      Price / FCF per ShareN/A (negative FCF)
      ✗Ackman<= 25
      Price vs. Trailing Low116% of trailing low ($6.57)
      ✓Templeton<= 120% of trailing low (certified split-adjusted live window)
      Net income / market capitalization-34.69%; #4886/6340 (top 77.1%)
      ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
      Positive book equity / market capitalization+0.2930; #3724/6449 (top 57.7%)
      ✗AsnessTop 30% of eligible cross-section
      Price / Diluted EPS
      ✗NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)
      (EPS CAGR % + Dividend Yield %) / P/E
      ✗Neff> 0.7 (Neff's published traditional edge)
      Price / Tangible Book Value per Share3.84x
      ✗SchlossP/TBV <= 1.00x (app cutoff)
      Book Value per Share Change-80.3%
      ✗SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)
      Revenue / market capitalization+0.3047; #3300/5247 (top 62.9%)
      ✗OshaughnessyTop 10% of eligible cross-section
      (Operating cash flow - capex) / market capitalization-30.64%; #3662/4519 (top 81.0%)
      ✗OshaughnessyTop 10% of eligible cross-section
      Trailing six-month price return through the evaluation date-13.18%; #3606/6202 (top 58.1%)
      ✗OshaughnessyTop 10% of eligible cross-section
    • Cash Flow0% pass✓ 1✗ 11▾

      No clean pass — all 10 investors flag at least one cash flow criterion

      Free Cash Flow Proxy$-180.7M
      ✗BuffettPositive and growing
      FCF Positive and Growing$-154.8M
      ✗LynchPositive and growing
      Operating Cash Flow$-124.0M
      ✗PiotroskiCFO > 0
      (CFO / Total Assets) vs ROACFO/Assets=-27.36%, ROA=-42.80%
      ✓PiotroskiCFO/Assets > ROA
      Price / (CFO / Shares)N/A (negative CFPS)
      ✗Dreman< 8x
      P/E or FCF YieldFCF Yield=-25.0%
      ✗PabraiP/E < 15 or FCF Yield > 10%
      FCF Positive2/11 years FCF positive
      ✗MarksPositive FCF in majority of recent years
      (OCF - CapEx) / Market Cap-39.3%
      ✗Ackman>= 4%
      Price / FCF per ShareN/A (negative FCF)
      ✗Ackman<= 25
      Positive Operating Cash Flow frequency2/13 years positive
      ✗SleepPositive OCF in >= 70% of available years
      Operating Cash Flow - Capital Expenditures$-154.8M
      ✗Neff> $0 (app proxy for a strong fundamental case)
      (Operating cash flow - capex) / market capitalization-30.64%; #3662/4519 (top 81.0%)
      ✗OshaughnessyTop 10% of eligible cross-section
    • Growth0% pass✓ 3✗ 10▾

      No clean pass — all 8 investors flag at least one growth criterion

      EPS Growth (3-yr avg, 10-yr window)N/A (negative base EPS)
      ✗Graham>= 33% growth
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      3-5 Year EPS CAGR
      ✗Lynch15-30% (Fast Grower); > 0% to pass
      Inventory Growth vs Revenue GrowthN/A (no inventory)
      ✓LynchInventory growth < Revenue growth
      EPS Growth Direction$-2.50 (2013) -> $-3.76 (2025)
      ✗DremanPositive over recent years
      EPS CAGR
      ✗Dreman> 5% annualized
      Positive Net Income Frequency2/13 years positive
      ✗MarksPositive net income in >= 7 of last 10 years
      3yr Median Revenue Growth-7.7%
      ✗Ackman>= 5%
      Positive EPS Growth Frequency4/5 years with positive EPS growth
      ✓AckmanPositive EPS growth in >= 3 of last 5 years
      5-Year EPS CAGR
      ✗Templeton> 0% (5-year EPS CAGR)
      Revenue growth vs. gross and operating margin trendrevenue up, operating margin -297.1% -> -94.6%
      ✓SleepRevenue rising; gross margin flat or falling; operating margin holding
      5-year Revenue CAGR2.0%
      ✗SleepCAGR > 7%
      3-5 Year Diluted EPS CAGR2.2% over 3 years
      ✗Neff7%-20% annualized
    • Profitability6% pass✓ 5✗ 30▾

      15 of 16 flag RGNX's profitability — Graham, Buffett, Lynch +12 more

      Positive EPS (10 years)2/14 years positive
      ✗GrahamPositive EPS every year for 10 years
      EPS Growth (3-yr avg, 10-yr window)N/A (negative base EPS)
      ✗Graham>= 33% growth
      Net Income Positive (10+ years)2/14 years positive
      ✗BuffettPositive every year for 10+ years
      ROE (up to 5-year arithmetic mean)-79.7%
      ✗Buffett> 15% arithmetic mean (app rule)
      Operating Margin (10-yr trend)-94.6% (latest)
      ✓BuffettStable or rising over 10 years
      Free Cash Flow Proxy$-180.7M
      ✗BuffettPositive and growing
      Earnings Variance (10-yr CoV)N/A (negative mean EPS)
      ✗BuffettCoV < 0.3
      Retained Earnings Effectiveness
      ✗Buffett$1 retained -> > $1 market value created
      Basic earnings-growth PEG (dividends excluded)
      ✗Lynch< 1.0 (ideally < 0.5)
      3-5 Year EPS CAGR
      ✗Lynch15-30% (Fast Grower); > 0% to pass
      ROE-118.4%
      ✗Lynch> 15%
      EBIT / Enterprise Value-34.2%
      ✗Greenblatt> 10%
      Earnings Yield + ROC AssessmentEY=-34.2%, ROC=-69.0%
      ✗GreenblattBoth EY > 10% and ROC > 25%
      Net Income / Total Assets-42.80%
      ✗PiotroskiROA > 0
      ROA Change YoY-48.74% -> -42.80% (delta: +5.94%)
      ✓PiotroskiCurrent ROA > Prior ROA
      (CFO / Total Assets) vs ROACFO/Assets=-27.36%, ROA=-42.80%
      ✓PiotroskiCFO/Assets > ROA
      Gross Margin Change YoY
      ✗PiotroskiImproved YoY
      Pre-Tax Income / Revenue-113.8%
      ✗Dreman>= 8%
      Net Income / Shareholders' Equity-118.4%
      ✗Dreman> 12%
      Margin of SafetyP/B=3.8x
      ✗PabraiP/B < 1.5 or P/E < 15
      Return on Equity-120.2% (3-yr avg)
      ✗AkreROE > 20% (3-year avg)
      Discount to Intrinsic ValueN/A (negative normalized EPS)
      ✗Marks>= 20% below intrinsic value
      Positive Net Income Frequency2/13 years positive
      ✗MarksPositive net income in >= 7 of last 10 years
      Operating Income / Revenue-95.7%
      ✗Ackman>= 15%
      Net Income / Shareholders Equity-118.4%
      ✗Ackman>= 15%
      5-Year EPS CAGR
      ✗Templeton> 0% (5-year EPS CAGR)
      Operating Margin Trend-297.1% (2023) -> -94.6% (2025)
      ✓TempletonNon-negative operating-margin trend over 3 years
      Revenue growth vs. gross and operating margin trendrevenue up, operating margin -297.1% -> -94.6%
      ✓SleepRevenue rising; gross margin flat or falling; operating margin holding
      Net income / market capitalization-34.69%; #4886/6340 (top 77.1%)
      ✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
      Gross profit / total assets
      ✗AsnessTop 30% of eligible cross-section
      Net income / positive book equity-118.36%; #4669/5226 (top 89.3%)
      ✗AsnessTop 30% of eligible cross-section
      Negative 5-year standard deviation of ROA-0.2228; #4330/5884 (top 73.6%)
      ✗AsnessTop 30% of eligible cross-section
      3-5 Year Diluted EPS CAGR2.2% over 3 years
      ✗Neff7%-20% annualized
      Positive Diluted-EPS Years2/10 years positive
      ✗Schloss>= 70% positive over 5-10 observed years (app rule)
    • Verdicts7% pass✓ 1✗ 14▾

      Split decision: 13 FAIL · 2 NEUTRAL · 1 PASS

      Overall verdict
      ✗GrahamFAIL (2/9)✗BuffettFAIL (3/9)✗LynchFAIL (1/7)✗GreenblattRank #2626✓PiotroskiPASS (F-Score 4)✗DremanFAIL (1/11)✗MungerFAIL (0/4)✗PabraiFAIL (0/3)✗AkreFAIL (1/6)✗MarksFAIL (0/5)✗AckmanFAIL (2/9)✗TempletonFAIL (3/8)✗SleepFAIL (2/6)•AsnessNEUTRAL (Not ranked)✗NeffFAIL (1/6)✗SchlossFAIL (1/7)•OshaughnessyNEUTRAL (Not ranked)
    • Debt & Leverage8% pass✓ 3✗ 12▾

      11 of 12 flag RGNX's debt & leverage — Graham, Buffett, Lynch +8 more

      LT Debt vs Net Current Assets
      ✗GrahamLT Debt <= Net Current Assets
      Debt/Equity & Interest Coverage
      ✗BuffettD/E < 0.5 AND Interest Coverage > 5x
      Total Debt / Equity
      ✗Lynch< 0.33
      Cash - Long-term Debt
      ✗LynchPositive preferred
      LT Debt / Total Assets Change0.00% -> 0.00%
      ✓PiotroskiDecreased YoY
      Current Assets / Current Liabilities4.74
      ✓Dreman> 1.5✓SchlossCurrent ratio >= 1.50x (app cutoff)
      Total Debt / Shareholders' Equity
      ✗Dreman< 0.8✗Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✗SchlossD/E < 1.00x
      Debt Levels
      ✗MungerDebt/Equity < 0.5✗AkreDebt/Equity < 0.3
      Interest Coverage & Debt/EBITDAIC=-3.6x, D/EBITDA=N/A
      ✗MarksInterest Coverage > 3x; Debt/EBITDA < 4x
      Total Debt / Shareholders Equity
      ✗Ackman<= 1.0
      Negative debt-to-equity (higher means less debt)
      ✗AsnessTop 30% of eligible cross-section
    • Efficiency38% pass✓ 5✗ 6▾

      5 of 8 flag RGNX's efficiency — Greenblatt, Piotroski, Munger +2 more

      Current Ratio4.74
      ✓Graham>= 2.0
      ROIC (3-5 yr avg)15.8%
      ✓Buffett> 10%
      ROIC - WACC+5.8%
      ✓BuffettPositive (WACC = 10%)
      EBIT / (NWC + Net Fixed Assets)-69.0%
      ✗Greenblatt> 25%
      Current Ratio Change YoY2.69 -> 2.38
      ✗PiotroskiIncreased YoY
      Revenue / Total Assets Change YoY0.18x -> 0.38x
      ✓PiotroskiImproved YoY
      Current Assets / Current Liabilities4.74
      ✓Dreman> 1.5
      Return on Invested Capital
      ✗Munger> 15%
      ROIC (high and growing)FY2023: ROIC=unavailable; FY2024: ROIC=unavailable; FY2025: ROIC=unavailable
      ✗AkreLatest 3 consecutive FYs: ROIC > 15% in each
      Reinvestment Rate x ROIC
      ✗AkreReinvestment Rate * ROIC > 10%
      ROIC (5-year)
      ✗SleepROIC > 12% in a majority of years

    Business & financials

    Financial snapshot: annual FY 2025. Current investor scores may use newer quarterly data.

    Company Profile

    Industry: Pharmaceutical Products
    SIC Sector: Chemicals & Pharmaceuticals
    Size: Small Cap($505.2M)
    Revenue: $170.4M+104.5% YoY
    Net Income: $193.9M+14.6% YoY

    Financial Snapshot

    Operating Margin-94.6%
    Return on Equity-188.7%
    Debt / Equity--
    Current Ratio2.38
    EPS (Diluted)$-3.76
    Shares Retired−3.0% / −16.2% 2y

    Shareholder Return

    Fiscal 2025

    Issued 3.0% of shares last year, 16.2% issued over two.

    Buybacks
    —
    Dividends
    —

    Company Financials

    Latest TTM and quarters alongside annual years

    TTM sums four consecutive quarters and uses the latest quarter-end balances. Quarter columns show three-month results; annual columns show full-year totals. Growth compares the same period a year earlier. EPS is not added for TTM; full-year ratios are blank for quarters.

    The latest annual period end is unavailable. Showing the latest fiscal cycle’s quarters; quarter and annual columns may overlap. Quarterly shows the full quarter history.

    MetricTTM · 2026-09-30

    2025-10-01 – 2026-09-30

    Sources · derived quarter values

    Derived from cumulative filings: revenue, net income, operating income, ebit, interest expense, operating cash flow, depreciation amortization, capex.

    Q3 FY 2026

    2026-07-01 – 2026-09-30

    Sources · derived quarter values

    Derived from cumulative filings: operating cash flow, depreciation amortization, capex.

    Q2 FY 2026

    2026-04-01 – 2026-06-30

    Sources · derived quarter values

    Derived from cumulative filings: operating cash flow, depreciation amortization, capex.

    Q1 FY 2026

    2026-01-01 – 2026-03-31

    Sources
    FY 2025
    Sources
    • 10-K · 2026-03-05
    FY 2024
    Sources
    • 10-K · 2025-03-13
    FY 2023
    Sources
    • 10-K · 2024-02-27
    FY 2022
    Sources
    • 10-K · 2023-02-28
    FY 2021
    Sources
    • 10-K · 2022-03-01
    Market Cap$505.2Mcurrent------$576.0Mest.$404.2Mest.$547.3Mest.$1.0Best.$1.1Best.
    Revenue$153.9M↓5%$9.2M↓69%$108.0M↑406%$6.4M↓93%$170.4M↑105%$83.3M↓8%$90.2M↓20%$112.7M↓76%$470.3M
    Operating Income-$147.3M↑5%-$35.5M↑32%$29.3M↑146%-$83.4M↓787%-$161.2M↑31%-$233.3M↑13%-$268.1M↓2%-$262.9M↓264%$160.0M
    Net Income-$175.2M↑2%-$40.7M↑34%$22.7M↑132%-$90.1M↓1580%-$193.9M↑15%-$227.1M↑14%-$263.5M↑6%-$280.3M↓319%$127.8M
    EPS (Diluted)--$-0.62↑48%$0.43↑131%$-1.72↓1533%$-3.76↑18%$-4.59↑24%$-6.02↑7%$-6.50↓323%$2.91
    Gross Margin—————59.7%↑2%58.8%↑14%51.6%↓42%89.0%
    Operating Margin-95.7%-387.8%↓120%27.1%↑109%-1304.0%↓9671%-94.6%↑66%-280.0%↑6%-297.1%↓27%-233.2%↓786%34.0%
    ROE-118.4%↓7%———-188.7%↓116%-87.5%↓3%-84.5%↓56%-54.3%↓425%16.7%
    Total Debt------------------
    Shareholders' Equity$148.0M↓8%$148.0M↓8%$71.8M↓66%$21.1M↓92%$102.7M↓60%$259.7M↓17%$311.7M↓40%$516.2M↓32%$764.3M
    Current Ratio4.74↑78%4.74↑78%2.86↓9%2.62↓11%2.38↓12%2.69↑5%2.57↓19%3.19↓20%3.98
    Debt / Equity—————————
    Operating Cash Flow-$152.1M↓47%$38.6M↑169%-$62.2M↓26%-$76.2M↓327%-$124.0M↑28%-$173.1M↑21%-$218.4M↓5%-$207.5M↓195%$218.9M
    Free Cash Flow-$154.8M↓46%$38.4M↑168%-$63.0M↓27%-$77.4M↓337%-$126.4M↑28%-$175.6M↑23%-$228.4M↑4%-$238.2M↓277%$134.7M

    Score history

    Historical Score Timeline

    Industry peers

    Industry Peers

    Similar companies in Pharmaceutical Products

    RGNX vs Peers — Financial Grading

    Revenue$170.4MBottom 25%
    Net Income$193.9MBottom 25%
    ROE-188.7%Bottom 25%
    D/E—
    Op. Margin-94.6%Bottom 25%
    Curr. Ratio2.38Median
    CompanyMarket CapPriceRevenueNet IncomeROED/EOp. MarginCurr. RatioGrahamBuffettLynchGreenblattPiotroskiDreman
    Merck & Co., Inc.MRK$364.3B$147.76$65.0B$18.3B34.7%0.94—1.542/95/94/70/3F-Score 41/11
    ABBOTT LABORATORIESABT$188.0B$108.52$44.3B$6.5B12.5%0.2518.2%1.583/94/92/71/3F-Score 53/11
    BRISTOL MYERS SQUIBB COBMY$129.7B$63.43$48.2B$7.1B38.2%2.4419.4%1.262/91/93/71/3F-Score 85/11
    BIO-TECHNE CorpTECH$11.4B$72.80$1.2B$73.4M3.8%—8.4%3.464/93/93/70/3F-Score 54/11
    REPLIGEN CORPRGEN$10.7B$167.79$738.3M$48.9M2.3%0.267.5%8.373/92/93/70/3F-Score 75/11
    IONIS PHARMACEUTICALS INCIONS$4.8B$29.06$943.7M$381.4M-78.0%3.60-40.4%3.833/91/91/70/3F-Score 43/11
    NEOGEN CORPNEOG$2.5B$11.23$870.4M$7.9M-0.4%0.76-2.5%3.823/91/92/70/3F-Score 64/11
    Pharvaris N.V.PHVS$2.4B$33.36—$206.4M-64.8%0.00——0/90/92/70/3F-Score 22/11