VERTEX PHARMACEUTICALS INC / MA

VRTX

Vertex Pharmaceuticals Incorporated operates as a biotechnology company in the United States, Europe, and internationally. The company offers transformative medicines for people with serious diseases with a focus on specialty markets, such as cystic fibrosis (CF), sickle cell disease (SCD), transfusion dependent beta thalassemia (TDT), and acute pain.

About the company

Country: United StatesPrice: $538.60Market Cap: $136.6B

Investment snapshot

18%positive consensus

Scored 1d ago

Positive

BUY / PASS

Neutral / negative

7 / 6

NEUTRAL / FAIL

Median fair value

$146.88

-72.7% vs price

Models with upside

0 / 17

Positive margin of safety

Strongest signal

11 of 12 pass — Asness objects

Key risk

No clean pass — all 13 investors flag at least one valuation criterion

Framework analysis

Verdict	Meaning
BUY	Positive purchase signal: the framework's buy requirements are met.
PASS	The company clears the framework's checklist or screen, but the framework does not produce a buy signal. For valuation frameworks this often means margin of safety is missing, insufficient, or unavailable; some screen-only frameworks have no intrinsic-value BUY state.
NEUTRAL	Neither a positive nor negative conclusion. It does not mean to hold an existing position.
FAIL	The company does not clear the framework's requirements.
Ranked	Ranked strategies do not use PASS: selected cohort is BUY, outside the cohort is FAIL, and unranked is NEUTRAL.

Current investor scores use trailing 12-month flows and the latest balance sheet where supported. Multi-year and EPS tests retain annual history; each framework shows its financial basis below. Intrinsic values use annual financials.

Metric	Graham Defensive Value	Buffett Quality Compounder	Lynch GARP	Greenblatt Magic Formula	Piotroski F-Score	Dreman Contrarian Value	Munger Quality Focus	Pabrai Dhandho Framework	Akre Three-Legged Stool	Marks Risk-Aware Value	Ackman Activist Value	Templeton Global Bargain Hunter	Sleep Scale Economies Shared	Asness Systematic Factors	Neff Low-P/E Total Return	Schloss Asset-Value Discipline	O'Shaughnessy Systematic Factor Composite
Verdict	FAIL	NEUTRAL	FAIL	FAIL · Rank #859 (Top 27.7%)	NEUTRAL	NEUTRAL	PASS	FAIL	PASS	FAIL	NEUTRAL	FAIL	NEUTRAL	BUY	FAIL	NEUTRAL	NEUTRAL
Score
Analysis	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…	Checking access…
Intrinsic Value (annual)					N/A								N/A	N/A	N/A	N/A	N/A
Margin of Safety	-238.4%	-200.7%	-324.3%	-568.5%	N/A	-297.1%	-135.2%	-112.2%	-1166.1%	-395.8%	-66.9%	-266.7%	N/A	N/A	N/A	N/A	N/A
Financial Basis	TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Annual history · FY 2025 Latest source filing: 2026-11-03 Score computed: 2026-11-14	Annual history · FY 2025 Latest source filing: 2026-02-13 Score computed: 2026-11-14	Annual history · FY 2025 · Balance sheet at 2026-09-30 · TTM ended 2026-09-30 vs 2025-09-30 · TTM ended 2026-09-30 Latest source filing: 2026-11-03 Score computed: 2026-11-14	TTM ended 2026-09-30 Latest source filing: 2026-11-03 Score computed: 2026-11-14	Annual history · FY 2025 Latest source filing: 2026-02-13 Score computed: 2026-11-14	Annual history · FY 2025 · TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Market data at 2026-11-01 Latest source filing: 2026-11-03 Score computed: 2026-11-14	Qualitative assessment · Annual history · FY 2025 · TTM ended 2026-09-30 · Balance sheet at 2026-09-30 Latest source filing: 2026-11-03 Score computed: 2026-11-14	Qualitative assessment · Annual history · FY 2025 Latest source filing: 2026-02-13 Score computed: 2026-11-14	Annual history · FY 2025 · Qualitative assessment · TTM ended 2026-09-30 · Balance sheet at 2026-09-30 Latest source filing: 2026-11-03 Score computed: 2026-11-14	Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-02-13 Score computed: 2026-11-14	Annual history · FY 2025 · TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Market data at 2026-11-01 Latest source filing: 2026-11-03 Score computed: 2026-11-14	Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 · Balance sheet at 2026-09-30 Latest source filing: 2026-11-03 Score computed: 2026-11-14	Annual history · FY 2025 · Qualitative assessment Latest source filing: 2026-02-13 Score computed: 2026-11-14	TTM ended 2026-09-30 · Balance sheet at 2026-09-30 · Price history 2025-01-01–2026-11-01 · Annual history · FY 2025 Latest source filing: 2026-11-03 Score computed: 2026-11-14	Annual history · FY 2025 · TTM ended 2026-09-30 Latest source filing: 2026-11-03 Score computed: 2026-11-14	Annual history · FY 2025 · Balance sheet at 2026-09-30 Latest source filing: 2026-11-03 Score computed: 2026-11-14	TTM ended 2026-09-30 · Annual history · FY 2025 · Price history 2025-01-01–2026-11-01 Latest source filing: 2026-11-03 Score computed: 2026-11-14

Where It Passes

Debt & Leverage92% pass✓ 14✗ 1▾
11 of 12 pass — Asness objects
LT Debt vs Net Current AssetsLT Debt $3.5B vs NCA $6.7B
✓GrahamLT Debt <= Net Current Assets
Debt/Equity & Interest CoverageD/E: 0.01, IC: 336.6x
✓BuffettD/E < 0.5 AND Interest Coverage > 5x
Total Debt / Equity0.22
✓Lynch< 0.33
Cash - Long-term Debt$1.5B
✓LynchPositive preferred
LT Debt / Total Assets Change0.00% -> 0.00%
✓PiotroskiDecreased YoY
Current Assets / Current Liabilities2.34
✓Dreman> 1.5✓SchlossCurrent ratio >= 1.50x (app cutoff)
Total Debt / Shareholders' Equity0.22
✓Dreman< 0.8✓Templeton< 1.0 (fixed cap; proxy for below-sector-median leverage)✓SchlossD/E < 1.00x
Debt Levels0.22
✓MungerDebt/Equity < 0.5✓AkreDebt/Equity < 0.3
Interest Coverage & Debt/EBITDAIC=336.6x, D/EBITDA=0.0x
✓MarksInterest Coverage > 3x; Debt/EBITDA < 4x
Total Debt / Shareholders Equity0.22
✓Ackman<= 1.0
Negative debt-to-equity (higher means less debt)-0.2151; #1732/4210 (top 41.1%)
✗AsnessTop 30% of eligible cross-section
Growth63% pass✓ 9✗ 4▾
5 of 8 pass — Graham, Lynch and Sleep object
EPS Growth (3-yr avg, 10-yr window)
✗Graham>= 33% growth
Basic earnings-growth PEG (dividends excluded)4.24
✗Lynch< 1.0 (ideally < 0.5)
3-5 Year EPS CAGR8.3%
✓Lynch15-30% (Fast Grower); > 0% to pass
Inventory Growth vs Revenue GrowthInv: 38.0% vs Rev: 10.5%
✗LynchInventory growth < Revenue growth
EPS Growth Direction$-3.27 (2008) -> $15.32 (2025)
✓DremanPositive over recent years
EPS CAGR39.8% CAGR over 14 years
✓Dreman> 5% annualized
Positive Net Income Frequency10/19 years positive
✓MarksPositive net income in >= 7 of last 10 years
3yr Median Revenue Growth10.5%
✓Ackman>= 5%
Positive EPS Growth Frequency3/5 years with positive EPS growth
✓AckmanPositive EPS growth in >= 3 of last 5 years
5-Year EPS CAGR8.3% CAGR over 5 years
✓Templeton> 0% (5-year EPS CAGR)
Revenue growth vs. gross and operating margin trendgross margin 87.2% -> 86.2%, operating margin 38.8% -> 34.8%
✗SleepRevenue rising; gross margin flat or falling; operating margin holding
5-year Revenue CAGR14.1%
✓SleepCAGR > 7%
3-5 Year Diluted EPS CAGR8.3% over 5 years
✓Neff7%-20% annualized
Efficiency63% pass✓ 8✗ 3▾
5 of 8 pass — Piotroski, Munger and Akre object
Current Ratio2.34
✓Graham>= 2.0
ROIC (3-5 yr avg)41.4%
✓Buffett> 10%
ROIC - WACC+31.4%
✓BuffettPositive (WACC = 10%)
EBIT / (NWC + Net Fixed Assets)97.4%
✓Greenblatt> 25%
Current Ratio Change YoY2.69 -> 2.90
✓PiotroskiIncreased YoY
Revenue / Total Assets Change YoY0.49x -> 0.47x
✗PiotroskiImproved YoY
Current Assets / Current Liabilities2.34
✓Dreman> 1.5
Return on Invested Capital13.4%
✗Munger> 15%
ROIC (high and growing)FY2023: ROIC=16.8%; FY2024: ROIC=-1.1%; FY2025: ROIC=17.6%
✗AkreLatest 3 consecutive FYs: ROIC > 15% in each
Reinvestment Rate x ROIC17.6% (RR=100% x ROIC=17.6%)
✓AkreReinvestment Rate * ROIC > 10%
ROIC (5-year)4/5 years above 12% (latest 17.6%)
✓SleepROIC > 12% in a majority of years

Where It Falls Short

Valuation0% pass✓ 1✗ 27▾
No clean pass — all 13 investors flag at least one valuation criterion
Price / 3-yr avg EPS59.6x
✗Graham<= 15x
Price-to-Book Ratio7.3x
✗Graham<= 1.5x
P/E x P/B436.60
✗Graham<= 22.5
Basic earnings-growth PEG (dividends excluded)4.24
✗Lynch< 1.0 (ideally < 0.5)
EBIT / Enterprise Value3.2%
✗Greenblatt> 10%
Earnings Yield + ROC AssessmentEY=3.2%, ROC=97.4%
✗GreenblattBoth EY > 10% and ROC > 25%
Price / EPS35.2x
✗Dreman< 12x✗Templeton< 12x (fixed ceiling; proxy for the market's cheapest 40%)
Price / (CFO / Shares)37.7x
✗Dreman< 8x
Price / Book Value per Share7.3x
✗Dreman< 1.2x✗Templeton< 1.5x✗SchlossP/B <= 0.80x (app cutoff)
Valuation ReasonablenessP/E=35.2x, OE Yield=2.7%
✗MungerP/E < 25 or Owner Earnings Yield > 5%
P/E or FCF YieldP/E=35.2x, FCF Yield=2.3%
✗PabraiP/E < 15 or FCF Yield > 10%
P/B or P/E vs. Historical AverageP/E=35.2x, P/B=7.3x
✗MarksP/E < 15 or P/B < 2.0
Discount to Intrinsic Value-297.1% (IV=$135.65 vs Price=$538.60)
✗Marks>= 20% below intrinsic value
Price / FCF per Share42.8x
✗Ackman<= 25
Price vs. Trailing Low138% of trailing low ($391.02)
✗Templeton<= 120% of trailing low (certified split-adjusted live window)
Net income / market capitalization+2.91%; #2404/6340 (top 37.9%)
✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
Positive book equity / market capitalization+0.1531; #4448/6449 (top 69.0%)
✗AsnessTop 30% of eligible cross-section
Price / Diluted EPS35.2x
✗NeffP/E <= 15x (app proxy for a P/E 40%-60% below the market)
(EPS CAGR % + Dividend Yield %) / P/E
✗Neff> 0.7 (Neff's published traditional edge)
Price / Tangible Book Value per Share7.98x
✗SchlossP/TBV <= 1.00x (app cutoff)
Book Value per Share Change+119.9%
✓SchlossLatest BVPS >= earliest BVPS over >= 3 years (app rule)
Revenue / market capitalization+0.0948; #4363/5247 (top 83.2%)
✗OshaughnessyTop 10% of eligible cross-section
(Operating cash flow - capex) / market capitalization+2.35%; #2196/4519 (top 48.6%)
✗OshaughnessyTop 10% of eligible cross-section
Trailing six-month price return through the evaluation date+26.02%; #1133/6202 (top 18.3%)
✗OshaughnessyTop 10% of eligible cross-section
Valuation models0% pass✗ 11▾
VRTX overvalued: all 11 models price fair value below $538.60 (median $146.88)
Graham fair value$159.15
✗Graham-238.4% margin vs $538.60
Buffett fair value$179.09
✗Buffett-200.7% margin vs $538.60
Lynch fair value$126.93
✗Lynch-324.3% margin vs $538.60
Greenblatt fair value$80.57
✗Greenblatt-568.5% margin vs $538.60
Dreman fair value$135.65
✗Dreman-297.1% margin vs $538.60
Munger fair value$229.04
✗Munger-135.2% margin vs $538.60
Pabrai fair value$253.85
✗Pabrai-112.2% margin vs $538.60
Akre fair value$42.54
✗Akre-1166.1% margin vs $538.60
Marks fair value$108.64
✗Marks-395.8% margin vs $538.60
Ackman fair value$322.69
✗Ackman-66.9% margin vs $538.60
Templeton fair value$146.88
✗Templeton-266.7% margin vs $538.60
Profitability25% pass✓ 18✗ 17▾
12 of 16 flag VRTX's profitability — Graham, Buffett, Lynch +9 more
Positive EPS (10 years)9/28 years positive
✗GrahamPositive EPS every year for 10 years
EPS Growth (3-yr avg, 10-yr window)
✗Graham>= 33% growth
Net Income Positive (10+ years)10/28 years positive
✗BuffettPositive every year for 10+ years
ROE (up to 5-year arithmetic mean)17.1%
✓Buffett> 15% arithmetic mean (app rule)
Operating Margin (10-yr trend)34.8% (latest)
✓BuffettStable or rising over 10 years
Free Cash Flow Proxy$3.8B
✓BuffettPositive and growing
Earnings Variance (10-yr CoV)2.18
✗BuffettCoV < 0.3
Retained Earnings Effectiveness
✗Buffett$1 retained -> > $1 market value created
Basic earnings-growth PEG (dividends excluded)4.24
✗Lynch< 1.0 (ideally < 0.5)
3-5 Year EPS CAGR8.3%
✓Lynch15-30% (Fast Grower); > 0% to pass
ROE19.0%
✓Lynch> 15%
EBIT / Enterprise Value3.2%
✗Greenblatt> 10%
Earnings Yield + ROC AssessmentEY=3.2%, ROC=97.4%
✗GreenblattBoth EY > 10% and ROC > 25%
Net Income / Total Assets15.42%
✓PiotroskiROA > 0
ROA Change YoY-2.38% -> 15.42% (delta: +17.79%)
✓PiotroskiCurrent ROA > Prior ROA
(CFO / Total Assets) vs ROACFO/Assets=14.16%, ROA=15.42%
✗PiotroskiCFO/Assets > ROA
Gross Margin Change YoY86.1% -> 86.2%
✓PiotroskiImproved YoY
Pre-Tax Income / Revenue36.7%
✓Dreman>= 8%
Net Income / Shareholders' Equity19.0%
✓Dreman> 12%
Margin of SafetyP/E=35.2x, P/B=7.3x
✗PabraiP/B < 1.5 or P/E < 15
Return on Equity12.8% (3-yr avg)
✗AkreROE > 20% (3-year avg)
Discount to Intrinsic Value-297.1% (IV=$135.65 vs Price=$538.60)
✗Marks>= 20% below intrinsic value
Positive Net Income Frequency10/19 years positive
✓MarksPositive net income in >= 7 of last 10 years
Operating Income / Revenue33.2%
✓Ackman>= 15%
Net Income / Shareholders Equity19.0%
✓Ackman>= 15%
5-Year EPS CAGR8.3% CAGR over 5 years
✓Templeton> 0% (5-year EPS CAGR)
Operating Margin Trend38.8% (2023) -> 34.8% (2025)
✗TempletonNon-negative operating-margin trend over 3 years
Revenue growth vs. gross and operating margin trendgross margin 87.2% -> 86.2%, operating margin 38.8% -> 34.8%
✗SleepRevenue rising; gross margin flat or falling; operating margin holding
Net income / market capitalization+2.91%; #2404/6340 (top 37.9%)
✗AsnessTop 30% of eligible cross-section✗OshaughnessyTop 10% of eligible cross-section
Gross profit / total assets+40.36%; #939/3702 (top 25.4%)
✓AsnessTop 30% of eligible cross-section
Net income / positive book equity+19.02%; #844/5226 (top 16.2%)
✓AsnessTop 30% of eligible cross-section
Negative 5-year standard deviation of ROA-0.0773; #3154/5884 (top 53.6%)
✗AsnessTop 30% of eligible cross-section
3-5 Year Diluted EPS CAGR8.3% over 5 years
✓Neff7%-20% annualized
Positive Diluted-EPS Years8/10 years positive
✓Schloss>= 70% positive over 5-10 observed years (app rule)
Cash Flow30% pass✓ 4✗ 8▾
7 of 10 flag VRTX's cash flow — Lynch, Piotroski, Dreman +4 more
Free Cash Flow Proxy$3.8B
✓BuffettPositive and growing
FCF Positive and Growing$3.2B
✗LynchPositive and growing
Operating Cash Flow$3.6B
✓PiotroskiCFO > 0
(CFO / Total Assets) vs ROACFO/Assets=14.16%, ROA=15.42%
✗PiotroskiCFO/Assets > ROA
Price / (CFO / Shares)37.7x
✗Dreman< 8x
P/E or FCF YieldP/E=35.2x, FCF Yield=2.3%
✗PabraiP/E < 15 or FCF Yield > 10%
FCF Positive11/18 years FCF positive
✓MarksPositive FCF in majority of recent years
(OCF - CapEx) / Market Cap2.3%
✗Ackman>= 4%
Price / FCF per Share42.8x
✗Ackman<= 25
Positive Operating Cash Flow frequency11/18 years positive
✗SleepPositive OCF in >= 70% of available years
Operating Cash Flow - Capital Expenditures$3.2B
✓Neff> $0 (app proxy for a strong fundamental case)
(Operating cash flow - capex) / market capitalization+2.35%; #2196/4519 (top 48.6%)
✗OshaughnessyTop 10% of eligible cross-section
Verdicts30% pass✓ 3✗ 7▾
Split decision: 7 NEUTRAL · 6 FAIL · 2 PASS · 1 BUY
Overall verdict
✗GrahamFAIL (3/9)•BuffettNEUTRAL (6/9)✗LynchFAIL (4/7)✗GreenblattRank #859•PiotroskiNEUTRAL (F-Score 7)•DremanNEUTRAL (7/11)✓MungerPASS (2/4)✗PabraiFAIL (0/3)✓AkrePASS (3/6)✗MarksFAIL (3/5)•AckmanNEUTRAL (7/9)✗TempletonFAIL (3/8)•SleepNEUTRAL (4/6)✓AsnessBUY (Rank #704/2370 (Top 29.7%))✗NeffFAIL (3/6)•SchlossNEUTRAL (4/7)•OshaughnessyNEUTRAL (Not ranked)

Business & financials

Financial snapshot: annual FY 2025. Current investor scores may use newer quarterly data.

Company Profile

Industry: Pharmaceutical Products

SIC Sector: Chemicals & Pharmaceuticals

Size: Large Cap($136.6B)

Revenue: $12.0B+8.9% YoY

Net Income: $4.0B+838.1% YoY

Financial Snapshot

Operating Margin34.8%

Return on Equity21.2%

Debt / Equity0.01

Current Ratio2.90

EPS (Diluted)$15.32+8.3% 1y

Buybacks (1y)$2.0B

Buybacks (2y)$3.2B

Shares Retired1.1% / 1.7% 2y

Similar Companies

MRKMerck & Co., Inc.

$364.3B

ABTABBOTT LABORATORIES

$188.0B

BMYBRISTOL MYERS SQUIBB CO

$129.7B

TECHBIO-TECHNE Corp

$11.4B

Shareholder Return

Fiscal 2025

Retired 1.1% of shares last year, 1.7% over two.

Buybacks: $2.0B
Dividends: —

What drove EPS

A buyback raises earnings per share without the company earning more. This splits each year's change into the two.

FY22

42.3% = 41.8% + 0.3%

FY23

8.3% = 9.0% + −0.6%

Earnings Fewer shares More shares

Share count is the denominator the filer used for diluted EPS, recovered as net income ÷ EPS — not the balance-sheet count, which is a point-in-time figure and would put the timing difference into this split. Years with a loss are omitted: a smaller share count makes a loss per share larger, so the decomposition inverts.

Company Financials

Latest TTM and quarters alongside annual years

TTM sums four consecutive quarters and uses the latest quarter-end balances. Quarter columns show three-month results; annual columns show full-year totals. Growth compares the same period a year earlier. EPS is not added for TTM; full-year ratios are blank for quarters.

The latest annual period end is unavailable. Showing the latest fiscal cycle’s quarters; quarter and annual columns may overlap. Quarterly shows the full quarter history.

Metric	TTM · 2026-09-30 2025-10-01 – 2026-09-30 Sources · derived quarter values 10-K · 2026-02-13 10-Q · 2026-05-05 10-Q · 2026-08-04 10-Q · 2026-11-03 Derived from cumulative filings: revenue, net income, operating income, ebit, pre tax income, interest expense, operating cash flow, depreciation amortization, capex, buybacks.	Q3 FY 2026 2026-07-01 – 2026-09-30 Sources · derived quarter values 10-Q · 2026-11-03 Derived from cumulative filings: operating cash flow, capex, buybacks.	Q2 FY 2026 2026-04-01 – 2026-06-30 Sources · derived quarter values 10-Q · 2026-08-04 Derived from cumulative filings: operating cash flow, capex, buybacks.	Q1 FY 2026 2026-01-01 – 2026-03-31 Sources 10-Q · 2026-05-05	FY 2025 Sources 10-K · 2026-02-13	FY 2024 Sources 10-K · 2025-02-13	FY 2023 Sources 10-K · 2024-02-15	FY 2022 Sources 10-K · 2023-02-10	FY 2021 Sources 10-K · 2022-02-09
Market Cap	$136.6Bcurrent	--	--	--	$119.4Best.	$118.6Best.	$111.9Best.	$83.1Best.	$61.9Best.
Revenue	$13.0B↑10%	$3.4B↑12%	$3.3B↑12%	$3.0B↑8%	$12.0B↑9%	$11.0B↑12%	$9.9B↑11%	$8.9B↑18%	$7.6B
Operating Income	$4.3B↑8%	$712.9M↓40%	$1.2B↑8%	$1.1B↑81%	$4.2B↑1892%	-$232.9M↓106%	$3.8B↓11%	$4.3B↑55%	$2.8B
Net Income	$4.0B↑8%	$653.6M↓40%	$1.1B↑6%	$1.0B↑60%	$4.0B↑838%	-$535.6M↓115%	$3.6B↑9%	$3.3B↑42%	$2.3B
EPS (Diluted)	--	$2.56↓39%	$4.31↑8%	$4.02↑61%	$15.32↑837%	$-2.08↓115%	$13.89↑8%	$12.82↑42%	$9.01
Gross Margin	—	—	—	—	86.2%	86.1%↓1%	87.2%↓1%	87.9%	88.1%
Operating Margin	33.2%↓2%	20.7%↓46%	37.4%↓4%	38.1%↑68%	34.8%↑1745%	-2.1%↓105%	38.8%↓19%	48.2%↑31%	36.7%
ROE	19.0%↓10%	—	—	—	21.2%↑749%	-3.3%↓116%	20.6%↓14%	23.9%↑3%	23.2%
Total Debt	$4.5B	$4.5B	--	--	$112.2M↓5%	$118.0M↓72%	$426.7M↓10%	$471.6M↓15%	$556.7M
Shareholders' Equity	$20.9B↑21%	$20.9B↑21%	$20.2B↑18%	$19.4B↑17%	$18.7B↑14%	$16.4B↓7%	$17.6B↑26%	$13.9B↑38%	$10.1B
Current Ratio	2.34↓1%	2.34↓1%	3.19↑26%	3.02↑14%	2.90↑8%	2.69↓32%	3.99↓17%	4.83↑8%	4.46
Debt / Equity	0.22	0.22	—	—	0.01↓16%	0.01↓70%	0.02↓28%	0.03↓39%	0.06
Operating Cash Flow	$3.7B↓1%	$643.1M↓48%	$1.1B↑5%	$1.4B↑74%	$3.6B↑837%	-$492.6M↓114%	$3.5B↓14%	$4.1B↑56%	$2.6B
Free Cash Flow	$3.2B↓4%	$545.8M↓52%	$1.0B↑9%	$1.3B↑66%	$3.2B↑504%	-$790.3M↓124%	$3.3B↓15%	$3.9B↑63%	$2.4B

Score history

Historical Score Timeline

Industry peers

Industry Peers

Similar companies in Pharmaceutical Products

VRTX vs Peers — Financial Grading

Revenue$12.0BMedian

Net Income$4.0BMedian

ROE21.2%Top 25%

D/E0.01Top 25%

Op. Margin34.8%Top 25%

Curr. Ratio2.90Median

Company	Market Cap	Price	Revenue	Net Income	ROE	D/E	Op. Margin	Curr. Ratio	Graham	Buffett	Lynch	Greenblatt	Piotroski	Dreman
Merck & Co., Inc.MRK	$364.3B	$147.76	$65.0B	$18.3B	34.7%	0.94	—	1.54	2/9	5/9	4/7	0/3	F-Score 4	1/11
ABBOTT LABORATORIESABT	$188.0B	$108.52	$44.3B	$6.5B	12.5%	0.25	18.2%	1.58	3/9	4/9	2/7	1/3	F-Score 5	3/11
BRISTOL MYERS SQUIBB COBMY	$129.7B	$63.43	$48.2B	$7.1B	38.2%	2.44	19.4%	1.26	2/9	1/9	3/7	1/3	F-Score 8	5/11
BIO-TECHNE CorpTECH	$11.4B	$72.80	$1.2B	$73.4M	3.8%	—	8.4%	3.46	4/9	3/9	3/7	0/3	F-Score 5	4/11
REPLIGEN CORPRGEN	$10.7B	$167.79	$738.3M	$48.9M	2.3%	0.26	7.5%	8.37	3/9	2/9	3/7	0/3	F-Score 7	5/11
IONIS PHARMACEUTICALS INCIONS	$4.8B	$29.06	$943.7M	$381.4M	-78.0%	3.60	-40.4%	3.83	3/9	1/9	1/7	0/3	F-Score 4	3/11
NEOGEN CORPNEOG	$2.5B	$11.23	$870.4M	$7.9M	-0.4%	0.76	-2.5%	3.82	3/9	1/9	2/7	0/3	F-Score 6	4/11
Pharvaris N.V.PHVS	$2.4B	$33.36	—	$206.4M	-64.8%	0.00	—	—	0/9	0/9	2/7	0/3	F-Score 2	2/11